The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Deep Brain Stimulation: Are Astrocytes a Key Driver Behind the Scene?

(2014) Albert J. Fenoy et al.   CNS Neuroscience & Therapeutics

Striatal allografts in patients with Huntington’s disease: impact of diminished astrocytes and vascularization on graft viability

(2013) Giulia Cisbani et al.   BRAIN

Physiological Challenges for Intracortical Electrodes

(2013) Jitte Groothuis et al.   Brain Stimulation

Intracerebral Transplantation of Adipose-Derived Mesenchymal Stem Cells Alternatively Activates Microglia and Ameliorates Neuropathological Deficits in Alzheimer's Disease Mice

(2013) Tuo Ma et al.   CELL TRANSPLANTATION

Transplantation of Enteric Neural Stem/Progenitor Cells into the Irradiated Young Mouse Hippocampus

(2013) Ahmed M. Osman et al.   CELL TRANSPLANTATION

Engraftment of Mouse Embryonic Stem Cells Differentiated by Default Leads to Neuroprotection, Behaviour Revival and Astrogliosis in Parkinsonian Rats

(2013) Debasmita Tripathy et al.   PLoS One

Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

(2012) Jelle Praet et al.   CELL TRANSPLANTATION

Deep Brain Stimulation of Pedunculopontine Tegmental Nucleus (PPTg) Promotes Cognitive and Metabolic Changes: A Target-Specific Effect or Response to a Low-Frequency Pattern of Stimulation?

(2012) A. Stefani et al.   CLINICAL EEG AND NEUROSCIENCE

Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

(2012) Nathalie De Vocht et al.   IMMUNOBIOLOGY

Postmortem observation of collagenous lead tip region fibrosis as a rare complication of DBS

(2012) Vinata Vedam-Mai et al.   MOVEMENT DISORDERS

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor

(2012) Mahmoud M. Iravani et al.   NEUROSCIENCE LETTERS

Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications

(2011) F. Cicchetti et al.   BRAIN

Intravenous administration of AAV2/9 to the fetal and neonatal mouse leads to differential targeting of CNS cell types and extensive transduction of the nervous system

(2011) Ahad A. Rahim et al.   FASEB JOURNAL

In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression

(2011) A A Rahim et al.   GENE THERAPY

Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe

(2011) J-P Louboutin et al.   GENE THERAPY

In Vivo Validation of Custom-Designed Silicon-Based Microelectrode Arrays for Long-Term Neural Recording and Stimulation

(2011) M. Han et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Characterization of astrocyte reactivity and gene expression on biomaterials for neural electrodes

(2011) Evon S. Ereifej et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Deep Brain Stimulation: Current and Future Clinical Applications

(2011) Mark K. Lyons   MAYO CLINIC PROCEEDINGS

Deep brain stimulation and the role of astrocytes

(2011) V Vedam-Mai et al.   MOLECULAR PSYCHIATRY

Transplantation of Neuronal-Primed Human Bone Marrow Mesenchymal Stem Cells in Hemiparkinsonian Rodents

(2011) Melissa L. M. Khoo et al.   PLoS One

Effects of Glial Cells on Electrode Impedance Recorded from Neural Prosthetic Devices In Vitro

(2010) John P. Frampton et al.   ANNALS OF BIOMEDICAL ENGINEERING

The national DBS brain tissue network pilot study: need for more tissue and more standardization

(2010) V. Vedam-Mai et al.   CELL AND TISSUE BANKING

Striatal Stimulation Nurtures Endogenous Neurogenesis and Angiogenesis in Chronic-Phase Ischemic Stroke Rats

(2010) Takamasa Morimoto et al.   CELL TRANSPLANTATION

Widespread enzymatic correction of CNS tissues by a single intracerebral injection of therapeutic lentiviral vector in leukodystrophy mouse models

(2010) Annalisa Lattanzi et al.   HUMAN MOLECULAR GENETICS

Gene therapy: a viable therapeutic strategy for Parkinson’s disease?

(2010) Alexander L. Berry et al.   JOURNAL OF NEUROLOGY

Early or Late-Stage Anti-N-Terminal Huntingtin Intrabody Gene Therapy Reduces Pathological Features in B6.HDR6/1 Mice

(2010) Abigail Snyder-Keller et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

(2010) Piotr Hadaczek et al.   MOLECULAR THERAPY

Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

(2010) Elena Moro et al.   MOVEMENT DISORDERS

Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains

(2010) Raymond T. Bartus et al.   MOVEMENT DISORDERS

Deep Brain Stimulation Results in Local Glutamate and Adenosine Release: Investigation Into the Role of Astrocytes

(2010) Vivianne L. Tawfik et al.   NEUROSURGERY

Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats

(2009) Yafit (Kuttner) Hirshler et al.   EXPERIMENTAL NEUROLOGY

Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration

(2009) George C McConnell et al.   Journal of Neural Engineering

Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients

(2009) Oliver Cooper et al.   JOURNAL OF NEUROLOGY

Control protocol for robust in vitro glial scar formation around microwires: Essential roles of bFGF and serum in gliosis

(2009) Vadim S. Polikov et al.   JOURNAL OF NEUROSCIENCE METHODS

EXPRESSION, BIOACTIVITY, AND SAFETY 1 YEAR AFTER ADENO-ASSOCIATED VIRAL VECTOR TYPE 2–MEDIATED DELIVERY OF NEURTURIN TO THE MONKEY NIGROSTRIATAL SYSTEM SUPPORT CERE-120 FOR PARKINSON'S DISEASE

(2009) Christopher D. Herzog et al.   NEUROSURGERY

Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

(2009) F. Cicchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Stimulation of the Cerebral Cortex Exerts Antiapoptotic, Angiogenic, and Anti-Inflammatory Effects in Ischemic Stroke Rats Through Phosphoinositide 3-Kinase/Akt Signaling Pathway

(2009) Tanefumi Baba et al.   STROKE

Characterization of microglial attachment and cytokine release on biomaterials of differing surface chemistry

(2008) Braden K. Leung et al.   BIOMATERIALS

Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study

(2008) Karsten Witt et al.   LANCET NEUROLOGY

Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum

(2008) Christopher D Herzog et al.   MOLECULAR THERAPY

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

(2008) Ivar Mendez et al.   NATURE MEDICINE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Effective Gene Therapy in a Mouse Model of Prion Diseases

(2008) Karine Toupet et al.   PLoS One

Continuous high-frequency stimulation in freely moving rats: Development of an implantable microstimulation system

(2007) Daniel Harnack et al.   JOURNAL OF NEUROSCIENCE METHODS

Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson’s disease

(2007) D.E. Redmond et al.   NEUROBIOLOGY OF DISEASE