Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells

Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis

(2014) Hyeun Joong Yoon et al.   ACS Nano

Dependence of Filopodia Morphology and the Separation Efficiency of Primary CD4+ T-Lymphocytes on Nanopillars

(2014) Gil-Sung Kim et al.   ANALYTICAL CHEMISTRY

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

(2013) Ruogang Zhao et al.   ADVANCED MATERIALS

Plasticity of primary microglia on micropatterned geometries and spontaneous long-distance migration in microfluidic channels

(2013) Susanna Amadio et al.   BMC NEUROSCIENCE

Microenvironment and tumor cell plasticity: An easy way out

(2013) Maria Letizia Taddei et al.   CANCER LETTERS

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

(2013) Stephanie Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

Time-dependent traction force microscopy for cancer cells as a measure of invasiveness

(2013) Valentina Peschetola et al.   Cytoskeleton

In vitro models of the metastatic cascade: from local invasion to extravasation

(2013) S. Bersini et al.   DRUG DISCOVERY TODAY

Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D

(2013) Casey M. Kraning-Rush et al.   Integrative Biology

Focal adhesions tug at matrix for rigidity sensing

(2013) Alexia-Ileana Zaromytidou   NATURE CELL BIOLOGY

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions

(2013) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gradient-free directional cell migration in continuous microchannels

(2013) Young-Gwang Ko et al.   Soft Matter

The role of filopodia in the recognition of nanotopographies

(2013) Jörg Albuschies et al.   Scientific Reports

Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery

(2013) M. H. Jorrisch et al.   Biology Open

Tomography and Static-Mechanical Properties of Adherent Cells

(2012) Siowling Soh et al.   ADVANCED MATERIALS

Bioengineering Methods for Analysis of Cells In Vitro

(2012) Gregory H. Underhill et al.   Annual Review of Cell and Developmental Biology

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness

(2012) Pranav Soman et al.   BIOMATERIALS

The switching of focal adhesion maturation sites and actin filament activation for MSCs by topography of well-defined micropatterned surfaces

(2012) Chang Ho Seo et al.   BIOMATERIALS

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship between Traction Forces and Focal Adhesions

(2012) Sangyoon J. Han et al.   BIOPHYSICAL JOURNAL

Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters

(2012) Liedewij Laan et al.   CELL

The first World Cell Race

(2012) Paolo Maiuri et al.   CURRENT BIOLOGY

Pathological roles of invadopodia in cancer invasion and metastasis

(2012) Hideki Yamaguchi   EUROPEAN JOURNAL OF CELL BIOLOGY

Epithelial cell guidance by self-generated EGF gradients

(2012) Cally Scherber et al.   Integrative Biology

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Microtubule guidance tested through controlled cell geometry

(2012) S. Huda et al.   JOURNAL OF CELL SCIENCE

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization

(2012) C. Mohl et al.   JOURNAL OF CELL SCIENCE

Microfabricated mimics of in vivo structural cues for the study of guided tumor cell migration

(2012) Daniel Gallego-Perez et al.   LAB ON A CHIP

Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device

(2012) Michael Mak et al.   LAB ON A CHIP

Modular Design of Micropattern Geometry Achieves Combinatorial Enhancements in Cell Motility

(2012) Keiichiro Kushiro et al.   LANGMUIR

A three-component mechanism for fibroblast migration with a contractile cell body that couples a myosin II–independent propulsive anterior to a myosin II–dependent resistive tail

(2012) Wei-hui Guo et al.   MOLECULAR BIOLOGY OF THE CELL

Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution

(2012) ZiQiu Tong et al.   PLoS One

3D Traction Forces in Cancer Cell Invasion

(2012) Thorsten M. Koch et al.   PLoS One

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Future Trends in Lung Cancer Diagnosis

(2012) Jared D. Christensen et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System

(2012) R. N. Germain et al.   SCIENCE

Targeting tumor cell motility to prevent metastasis

(2011) Trenis D. Palmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration

(2011) Yu Huang et al.   Biomicrofluidics

Measuring Traction Forces of Motile Dendritic Cells on Micropost Arrays

(2011) Brendon G. Ricart et al.   BIOPHYSICAL JOURNAL

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

(2011) Shang-You Tee et al.   BIOPHYSICAL JOURNAL

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

(2011) Ana Sala et al.   Integrative Biology

Magnetic micropillars as a tool to govern substrate deformations

(2011) Jimmy le Digabel et al.   LAB ON A CHIP

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels

(2011) Qingzong Tseng et al.   LAB ON A CHIP

Cell Fluidics: Producing Cellular Streams on Micropatterned Synthetic Surfaces

(2011) Maurizio Ventre et al.   LANGMUIR

Steering Cell Migration Using Microarray Amplification of Natural Directional Persistence

(2011) Girish Kumar et al.   LANGMUIR

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From Molecular Signal Activation to Locomotion: An Integrated, Multiscale Analysis of Cell Motility on Defined Matrices

(2011) Amit Pathak et al.   PLoS One

Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics

(2011) Michael Mak et al.   PLoS One

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

(2011) L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

(2011) Renaud Poincloux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Filopodia and adhesion in cancer cell motility

(2011) Antti Arjonen et al.   Cell Adhesion & Migration

Filopodia initiation

(2011) Changsong Yang et al.   Cell Adhesion & Migration

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Reprogramming Directional Cell Motility by Tuning Micropattern Features and Cellular Signals

(2010) Keiichiro Kushiro et al.   ADVANCED MATERIALS

Affinity, lateral mobility, and clustering contribute independently to β2-integrin-mediated adhesion

(2010) Tao Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reaction-Diffusion Systems in Intracellular Molecular Transport and Control

(2010) Siowling Soh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The regulation of traction force in relation to cell shape and focal adhesions

(2010) Andrew D. Rape et al.   BIOMATERIALS

Programmable microfluidic patterning of protein gradients on hydrogels

(2010) Simone Allazetta et al.   CHEMICAL COMMUNICATIONS

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

Biological applications of microfluidic gradient devices

(2010) Sudong Kim et al.   Integrative Biology

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Microtubule +TIPs at a glance

(2010) A. Akhmanova et al.   JOURNAL OF CELL SCIENCE

Micropatterned Dynamically Adhesive Substrates for Cell Migration

(2010) Srivatsan Raghavan et al.   LANGMUIR

Microfabricated substrates as a tool to study cell mechanotransduction

(2010) Jimmy le Digabel et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Microfluidic tools for cell biological research

(2010) Guilhem Velve-Casquillas et al.   Nano Today

Bundles from boundaries

(2010) Denis Wirtz et al.   NATURE MATERIALS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Impact of Tumor Cell Cytoskeleton Organization on Invasiveness and Migration: A Microchannel-Based Approach

(2010) Claudio G. Rolli et al.   PLoS One

Two Distinct Filopodia Populations at the Growth Cone Allow to Sense Nanotopographical Extracellular Matrix Cues to Guide Neurite Outgrowth

(2010) Kyung-Jin Jang et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Short-term molecular polarization of cells on symmetric and asymmetric micropatterns

(2010) Kristiana Kandere-Grzybowska et al.   Soft Matter

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

A microfluidic wound-healing assay for quantifying endothelial cell migration

(2009) Andries D. van der Meer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Microengineered Platforms for Cell Mechanobiology

(2009) Deok-Ho Kim et al.   Annual Review of Biomedical Engineering

Regulation of microtubule dynamic instability

(2009) Babet van der Vaart et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording

(2009) Melanie Jungblut et al.   BIOMEDICAL MICRODEVICES

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

The cytoskeleton and cancer

(2009) Alan Hall   CANCER AND METASTASIS REVIEWS

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Mammalian end binding proteins control persistent microtubule growth

(2009) Yulia Komarova et al.   JOURNAL OF CELL BIOLOGY

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

An integrated microfluidic device for large-scale in situ click chemistry screening

(2009) Yanju Wang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Directing cell motions on micropatterned ratchets

(2009) Goher Mahmud et al.   Nature Physics

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pushing off the Walls: A Mechanism of Cell Motility in Confinement

(2009) R. J. Hawkins et al.   PHYSICAL REVIEW LETTERS

Diagnostic aids in the screening of oral cancer

(2009) Stefano Fedele   Head and Neck Optical Diagnostics Society

Cancer Statistics, 2008

(2008) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Navigating through models of chemotaxis

(2008) Pablo A Iglesias et al.   CURRENT OPINION IN CELL BIOLOGY

Src and focal adhesion kinase as therapeutic targets in cancer

(2008) Valerie G Brunton et al.   CURRENT OPINION IN PHARMACOLOGY

Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation

(2008) Nan Xia et al.   FASEB JOURNAL

In migrating cells, the Golgi complex and the position of the centrosome depend on geometrical constraints of the substratum

(2008) F. Pouthas et al.   JOURNAL OF CELL SCIENCE

Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites

(2008) A. Efimov et al.   JOURNAL OF CELL SCIENCE

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

A multi-purpose microfluidic perfusion system with combinatorial choice of inputs, mixtures, gradient patterns, and flow rates

(2008) Gregory A. Cooksey et al.   LAB ON A CHIP

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Surface area regulation: underexplored yet crucial in cell motility

(2008) Robert R. Kay et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Subcellular curvature at the perimeter of micropatterned cells influences lamellipodial distribution and cell polarity

(2008) Jane James et al.   CELL MOTILITY AND THE CYTOSKELETON