Journal
ADVANCED MATERIALS
Volume 24, Issue 42, Pages 5719-5726Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201200492
Keywords
cell mechanics; cell shapes; confocal microscopy; micropatterning; cortical actin
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Funding
- NIH [1R21CA137707-03]
- Center of Cancer Nanotechnology Excellence (CCNE) initiative of the National Institutes of Health (NIH) [U54 CA151880]
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A tomography approach is used to reconstruct 3D cell shapes and, simultaneously, the shapes/positions of the nuclei within these cells. Subjecting the cells to well-defined microconfinements of various diameters allow for relating the steady-state shapes of cells to their static-mechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.
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