Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-08-21
DOI
10.3389/fimmu.2015.00418
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages
- (2015) Wenjiang Yan et al. GUT
- The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects
- (2015) Xiaoling Tian et al. JOURNAL OF IMMUNOLOGY
- Mechanistic Assessment of PD-1H Coinhibitory Receptor–Induced T Cell Tolerance to Allogeneic Antigens
- (2015) Dallas B. Flies et al. JOURNAL OF IMMUNOLOGY
- Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226
- (2015) Christopher A. Fuhrman et al. JOURNAL OF IMMUNOLOGY
- Coexpression of TIGIT and FCRL3 Identifies Helios+Human Memory Regulatory T Cells
- (2015) Khalid Bin Dhuban et al. JOURNAL OF IMMUNOLOGY
- Rapid Eradication of a Bulky Melanoma Mass with One Dose of Immunotherapy
- (2015) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses
- (2015) Jun Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
- (2015) T. Kouo et al. Cancer Immunology Research
- The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
- (2014) Robert J. Johnston et al. CANCER CELL
- VISTA Is an Immune Checkpoint Molecule for Human T Cells
- (2014) J. L. Lines et al. CANCER RESEARCH
- VISTA Regulates the Development of Protective Antitumor Immunity
- (2014) I. Le Mercier et al. CANCER RESEARCH
- LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
- (2014) F. Xu et al. CANCER RESEARCH
- A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α+ DCs to Promote Long-Term T Cell Responses
- (2014) Xuanming Yang et al. Cell Host & Microbe
- Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses
- (2014) Nicole Joller et al. IMMUNITY
- T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling
- (2014) Man Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased expression of TIGIT on CD4+T cells ameliorates immune-mediated bone marrow failure of aplastic anemia
- (2014) Tao Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity
- (2014) Dallas B. Flies et al. JOURNAL OF CLINICAL INVESTIGATION
- Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions
- (2014) K. Nagahara et al. JOURNAL OF IMMUNOLOGY
- B and T Lymphocyte Attenuator Regulates T Cell Survival in the Lung
- (2014) C. Deppong et al. JOURNAL OF IMMUNOLOGY
- Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II
- (2014) Bitao Liang et al. JOURNAL OF IMMUNOLOGY
- Trafficking of LAG-3 to the Surface on Activated T Cells via Its Cytoplasmic Domain and Protein Kinase C Signaling
- (2014) Joonbeom Bae et al. JOURNAL OF IMMUNOLOGY
- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
- (2014) Yu-Hwa Huang et al. NATURE
- The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
- (2014) Christopher J Chan et al. NATURE IMMUNOLOGY
- Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation
- (2014) Emanuela I. Sega et al. PLoS One
- Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
- (2014) Nicholas M. Durham et al. PLoS One
- Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals
- (2014) Preeti Bharaj et al. PLoS One
- Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity
- (2014) L. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Agonistic Anti-BTLA mAb (3C10) Induced Generation of IL-10-Dependent Regulatory CD4+ T Cells and Prolongation of Murine Cardiac Allograft
- (2014) Masateru Uchiyama et al. TRANSPLANTATION
- Co-Inhibitory Pathways and Their Importance in Immune Regulation
- (2014) Naoka Murakami et al. TRANSPLANTATION
- The co-receptor BTLA negatively regulates human V 9V 2 T-cell proliferation: a potential way of immune escape for lymphoma cells
- (2013) J. Gertner-Dardenne et al. BLOOD
- Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells
- (2013) Y. Zhang et al. BLOOD
- Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses
- (2013) Feng-Cheng Chou et al. CELL TRANSPLANTATION
- Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
- (2013) Noa Stanietsky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses
- (2013) Vasileios Bekiaris et al. IMMUNITY
- T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response
- (2013) X. Yang et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: DNAX Accessory Molecule 1-Deficient CD8+ T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity
- (2013) K. M. Ramsbottom et al. JOURNAL OF IMMUNOLOGY
- The Influence of T Cell Ig Mucin-3 Signaling on Central Nervous System Autoimmune Disease Is Determined by the Effector Function of the Pathogenic T Cells
- (2013) S. Y. Lee et al. JOURNAL OF IMMUNOLOGY
- Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
- (2013) Nicola Gagliani et al. NATURE MEDICINE
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Toll-Like Receptor Ligands Induce Expression of the Costimulatory Molecule CD155 on Antigen-Presenting Cells
- (2013) Neha Kamran et al. PLoS One
- Tim-3 Expression Defines Regulatory T Cells in Human Tumors
- (2013) Jing Yan et al. PLoS One
- Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3
- (2013) Masahiro Moritoki et al. PLoS One
- Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling
- (2013) Cheng J. Ma et al. PLoS One
- CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLA
- (2013) Rachel Flynn et al. PLoS One
- TIM-3 Does Not Act as a Receptor for Galectin-9
- (2013) Judith Leitner et al. PLoS Pathogens
- Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells
- (2013) Amandine Legat et al. Frontiers in Immunology
- TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
- (2013) Kaori Sakuishi et al. OncoImmunology
- Uncovering a novel function of BTLA on tumor-infiltrating CD8+ T cells
- (2013) Cara Haymaker et al. Journal for ImmunoTherapy of Cancer
- Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
- (2012) R. G. Veenstra et al. BLOOD
- Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells
- (2012) S Liu et al. CELL DEATH AND DIFFERENTIATION
- Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner
- (2012) Souichi Oomizu et al. CLINICAL IMMUNOLOGY
- IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
- (2012) Zhi-Zhang Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- The Tim3-Galectin 9 Pathway Induces Antibacterial Activity in Human Macrophages Infected with Mycobacterium tuberculosis
- (2012) I. Sada-Ovalle et al. JOURNAL OF IMMUNOLOGY
- The TIGIT/CD226 Axis Regulates Human T Cell Function
- (2012) E. Lozano et al. JOURNAL OF IMMUNOLOGY
- TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance
- (2012) L. Chabtini et al. JOURNAL OF IMMUNOLOGY
- Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
- (2012) Shigeki Chiba et al. NATURE IMMUNOLOGY
- TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression
- (2012) Xin Gao et al. PLoS One
- CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection
- (2012) Megan J. Welch et al. VIROLOGY
- LAG-3, TGF- , and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L
- (2011) C. L. Lucas et al. BLOOD
- Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway
- (2011) Y. Sakoda et al. BLOOD
- Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
- (2011) Q. Zhou et al. BLOOD
- CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
- (2011) J. Fourcade et al. CANCER RESEARCH
- Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
- (2011) S.-R. Woo et al. CANCER RESEARCH
- Vstm3 is a member of the CD28 family and an important modulator of T-cell function
- (2011) Steven D. Levin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
- (2011) Li Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
- (2011) Taku Okazaki et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions
- (2011) N. Joller et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models
- (2011) D. B. Flies et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
- (2011) M. Bettini et al. JOURNAL OF IMMUNOLOGY
- Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
- (2011) J. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- Active Immunotherapy Combined With Blockade of a Coinhibitory Pathway Achieves Regression of Large Tumor Masses in Cancer-prone Mice
- (2011) Marcio O Lasaro et al. MOLECULAR THERAPY
- Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection
- (2011) Ying Zhang et al. PLoS One
- T-bet, a Th1 transcription factor regulates the expression of Tim-3
- (2010) Ana C. Anderson et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Loss of DNAM-1 contributes to CD8+T-cell exhaustion in chronic HIV-1 infection
- (2010) Marina Cella et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4
- (2010) Seng-Ryong Woo et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner
- (2010) Yoichiro Uchida et al. GASTROENTEROLOGY
- Galectin-9 regulates T helper cell function independently of Tim-3
- (2010) E. W. Su et al. GLYCOBIOLOGY
- BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
- (2010) Laurent Derré et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression
- (2010) Jörn C. Albring et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tim3 binding to galectin-9 stimulates antimicrobial immunity
- (2010) Pushpa Jayaraman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients
- (2010) Julien Fourcade et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors
- (2010) S. Takamura et al. JOURNAL OF IMMUNOLOGY
- Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
- (2010) V. Dardalhon et al. JOURNAL OF IMMUNOLOGY
- TIM-3: A Novel Regulatory Molecule of Alloimmune Activation
- (2010) O. Boenisch et al. JOURNAL OF IMMUNOLOGY
- T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells
- (2010) Rosemarie H. DeKruyff et al. JOURNAL OF IMMUNOLOGY
- Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
- (2010) H.-T. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor-infiltrating NY-ESO-1–specific CD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
- (2010) Junko Matsuzaki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
- (2010) A. K. Maiti et al. RHEUMATOLOGY
- Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+ T Cell Response
- (2010) Sharvan Sehrawat et al. PLoS Pathogens
- Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
- (2009) M. Nakayama et al. BLOOD
- TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
- (2009) William D. Hastings et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- DNAM-1/CD155 Interactions Promote Cytokine and NK Cell-Mediated Suppression of Poorly Immunogenic Melanoma Metastases
- (2009) C. J. Chan et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: B and T Lymphocyte Attenuator Signaling on NKT Cells Inhibits Cytokine Release and Tissue Injury in Early Immune Responses
- (2009) M. L. Miller et al. JOURNAL OF IMMUNOLOGY
- Soluble B and T Lymphocyte Attenuator Possesses Antitumor Effects and Facilitates Heat Shock Protein 70 Vaccine-Triggered Antitumor Immunity against a Murine TC-1 Cervical Cancer Model In Vivo
- (2009) L. Han et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance Induction
- (2009) X. Liu et al. JOURNAL OF IMMUNOLOGY
- Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells
- (2009) J. F. Grosso et al. JOURNAL OF IMMUNOLOGY
- LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis
- (2009) C. J. Workman et al. JOURNAL OF IMMUNOLOGY
- Role of Tim-3/Galectin-9 Inhibitory Interaction in Viral-Induced Immunopathology: Shifting the Balance toward Regulators
- (2009) S. Sehrawat et al. JOURNAL OF IMMUNOLOGY
- T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment
- (2009) T. C. Cheung et al. JOURNAL OF IMMUNOLOGY
- Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
- (2009) L. Golden-Mason et al. JOURNAL OF VIROLOGY
- CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
- (2009) T. Okamura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unconventional ligand activation of herpesvirus entry mediator signals cell survival
- (2009) T. C. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
- (2009) N. Stanietsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Galectin-9 Significantly Prolongs the Survival of Fully Mismatched Cardiac Allografts in Mice
- (2009) Wentao He et al. TRANSPLANTATION
- Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
- (2008) Yoshihiro Oya et al. ARTHRITIS AND RHEUMATISM
- ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
- (2008) A. Soriani et al. BLOOD
- Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
- (2008) Masako Seki et al. CLINICAL IMMUNOLOGY
- CD226 Gly307Ser association with multiple autoimmune diseases
- (2008) J P Hafler et al. GENES AND IMMUNITY
- Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells
- (2008) Feng Wang et al. IMMUNOBIOLOGY
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
- (2008) R. Brad Jones et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Accelerated tumor growth in mice deficient in DNAM-1 receptor
- (2008) Akiko Iguchi-Manaka et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A crucial role for HVEM and BTLA in preventing intestinal inflammation
- (2008) Marcos W. Steinberg et al. JOURNAL OF EXPERIMENTAL MEDICINE
- DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors
- (2008) Susan Gilfillan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
- (2008) Guifang Cai et al. NATURE IMMUNOLOGY
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
- (2008) Xin Yu et al. NATURE IMMUNOLOGY
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now