CLCA1 and TMEM16A: the link towards a potential cure for airway diseases

Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

(2015) Monica Sala-Rabanal et al.   eLife

The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation

(2015) Zeynep Yurtsever et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

(2014) Erika H. De Boever et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma

(2013) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mCLCA3 Does Not Contribute to Calcium-Activated Chloride Conductance in Murine Airways

(2012) Lars Mundhenk et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation

(2012) Zeynep Yurtsever et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation

(2012) Pinelopi Anagnostopoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-13–induced airway mucus production is attenuated by MAPK13 inhibition

(2012) Yael G. Alevy et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma

(2010) Gail M. Gauvreau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma

(2010) Dave Singh et al.   BMC Pulmonary Medicine

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents

(2009) Martine Hamann et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Role of CLCA Proteins in Inflammatory Airway Disease

(2008) Anand C. Patel et al.   Annual Review of Physiology

Airway mucus: The good, the bad, the sticky

(2008) Christopher M. Evans et al.   PHARMACOLOGY & THERAPEUTICS

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE

Regulation of Airway Mucin Gene Expression

(2007) Philip Thai et al.   Annual Review of Physiology