The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

(2012) Brandon S Pybus et al.   MALARIA JOURNAL

Rationale for short course primaquine in Africa to interrupt malaria transmission

(2012) Alice C Eziefula et al.   MALARIA JOURNAL

Optimising Strategies for Plasmodium falciparum Malaria Elimination in Cambodia: Primaquine, Mass Drug Administration and Artemisinin Resistance

(2012) Richard J. Maude et al.   PLoS One

Review: Improving the Therapeutic Index of 8-Aminoquinolines by the Use of Drug Combinations: Review of the Literature and Proposal for Future Investigations

(2011) Hla Y. Myint et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

How and Why to Screen for CYP2D6 Interindividual Variability in Patients Under Pharmacological Treatments

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Primaquine revisited six decades after its discovery

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