Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application

Joint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U.S. Men and Women of European Ancestry

(2013) Marilyn C. Cornelis   ANNALS OF INTERNAL MEDICINE

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

(2013) R. Saxena et al.   DIABETES

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

(2013) R. C. W. Ma et al.   DIABETOLOGIA

Genome-wide association study identifies three novel loci for type 2 diabetes

(2013) Kazuo Hara et al.   HUMAN MOLECULAR GENETICS

Type 2 Diabetes Risk Alleles NearBCAR1and inANK1Associate With Decreased β-Cell Function Whereas Risk Alleles NearANKRD55andGRB14Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort

(2013) Marie N. Harder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Patients With Medium-Chain Acyl–Coenzyme A Dehydrogenase Deficiency Have Impaired Oxidation of Fat During Exercise but No Effect ofl-Carnitine Supplementation

(2013) K. L. Madsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation

(2013) J.S.B. Willson et al.   JOURNAL OF HEPATOLOGY

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

(2013)   NATURE

Gene-Environment Interactions in the Development of Type 2 Diabetes: Recent Progress and Continuing Challenges

(2012) Marilyn C. Cornelis et al.   Annual Review of Nutrition

GRK5 ablation contributes to insulin resistance

(2012) Li Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients

(2012) Xing-Ping Dai et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Influence of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Sulfonylurea Drugs

(2012) Hongmei Xu et al.   CURRENT DRUG METABOLISM

A Genome-Wide Association Study IdentifiesGRK5andRASGRP1as Type 2 Diabetes Loci in Chinese Hans

(2012) Huaixing Li et al.   DIABETES

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21

(2012) R. Tabassum et al.   DIABETES

Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African Americans

(2012) J. N. Cooke et al.   DIABETES CARE

Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals

(2012) M. Iwata et al.   DIABETES CARE

Diabetes prevalence and determinants in adults in China mainland from 2000 to 2010: A systematic review

(2012) Hang Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals

(2012) B. Xi et al.   DIABETOLOGIA

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

(2012) O. Le Bacquer et al.   DIABETOLOGIA

Effect of CYP2C9 and SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of nateglinide in healthy Chinese male volunteers

(2012) Yu Cheng et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population

(2012) Tran Quang Binh et al.   GENE

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

(2012) Minako Imamura et al.   HUMAN MOLECULAR GENETICS

Individualized Therapy for Type 2 Diabetes

(2012) Gaia Chiara Mannino et al.   Molecular Diagnosis & Therapy

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

The Influence of MDR1 G2677T/A Genetic Polymorphisms on the Pharmacokinetics of Repaglinide in Healthy Chinese Volunteers

(2012) Qian Xiang et al.   PHARMACOLOGY

A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population

(2012) Hisashi Fukuda et al.   PLoS One

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

(2012) Wilfred Ip et al.   Cell and Bioscience

Genetics of type 2 diabetes in European populations

(2012) Qibin QI et al.   Journal of Diabetes

NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

(2011) Fei-Feng Sheng et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort

(2011) Yi-Cheng Chang et al.   CLINICAL ENDOCRINOLOGY

A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to Metformin

(2011) J H Choi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals

(2011) J. E. Below et al.   DIABETOLOGIA

Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations

(2011) S. D. Rees et al.   DIABETOLOGIA

Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: Phase I results of the Indian Council of Medical Research–INdia DIABetes (ICMR–INDIAB) study

(2011) R. M. Anjana et al.   DIABETOLOGIA

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

(2011) T. Nielsen et al.   DIABETOLOGIA

Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

(2011) Y. Takeda et al.   DIABETOLOGIA

Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers

(2011) Jiake He et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients

(2011) A. Surendiran et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Genomics and Drug Response

(2011) Liewei Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c

(2011) Mette M.H. Christensen et al.   Pharmacogenetics and Genomics

Pharmacogenomics of oral antidiabetic medications: current data and pharmacoepigenomic perspective

(2011) Vangelis G Manolopoulos et al.   PHARMACOGENOMICS

Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes

(2011) Simon D. Rees et al.   PLoS One

Genetic Polymorphisms of SLCO1B1 for Drug Pharmacokinetics and Its Clinical Implications

(2011) Hiroshi TAKANE   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Pharmacogenetics in type 2 diabetes: potential implications for clinical practice

(2011) Chunmei Huang et al.   Genome Medicine

The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulatesSlc30a8gene transcription through an intronic enhancer

(2010) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians

(2010) L. Bian et al.   DIABETES

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Impact of Common Variants ofPPARG,KCNJ11,TCF7L2,SLC30A8,HHEX,CDKN2A,IGF2BP2, andCDKAL1on the Risk of Type 2 Diabetes in 5,164 Indians

(2010) Ganesh Chauhan et al.   DIABETES

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

(2010) J. M. de Miguel-Yanes et al.   DIABETES CARE

Genetic variants of the insulin receptor substrate-1 are influencing the therapeutic efficacy of oral antidiabetics

(2010) A. Seeringer et al.   DIABETES OBESITY & METABOLISM

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians

(2010) L. Bian et al.   DIABETOLOGIA

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

(2010) T. W. Boesgaard et al.   DIABETOLOGIA

Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients

(2010) Qiong Huang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes

(2010) Lu Qi et al.   HUMAN MOLECULAR GENETICS

Effects of the Peroxisome Proliferator Activated Receptor-γ Coactivator-1α(PGC-1α) Thr394ThrandGly482SerPolymorphisms on Rosiglitazone Response in Chinese Patients With Type 2 Diabetes Mellitus

(2010) Ke-Han Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Replication of recently described type 2 diabetes gene variants in a South Indian population

(2010) Manickam Chidambaram et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Meta-analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

(2010) Yun Liu et al.   Obesity

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea

(2010) Matthijs L. Becker et al.   Pharmacogenetics and Genomics

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort

(2010) Jie Wen et al.   PLoS One

Type 2 Diabetes Susceptibility Gene Expression in Normal or Diabetic Sorted Human Alpha and Beta Cells: Correlations with Age or BMI of Islet Donors

(2010) Clare L. Kirkpatrick et al.   PLoS One

Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies

(2010) Min Xu et al.   PLoS One

Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice

(2010) Motoyuki Tamaki et al.   Islets

Identification of New Genetic Risk Variants for Type 2 Diabetes

(2010) Xiao Ou Shu et al.   PLoS Genetics

A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese

(2010) Fuu-Jen Tsai et al.   PLoS Genetics

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in KCNQ1 Associates With Fasting Glucose and -Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore

(2009) J. T. Tan et al.   DIABETES

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic  -Cell Function

(2009) A. M. Simonis-Bik et al.   DIABETES

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion

(2009) K. Mussig et al.   DIABETES

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population

(2009) C. Hu et al.   DIABETOLOGIA

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

(2009) T. Rönn et al.   DIABETOLOGIA

A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes

(2009) Hideichi MAKINO et al.   ENDOCRINE JOURNAL

Diabetes in Asia

(2009) Ambady Ramachandran et al.   LANCET

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

(2009) M L Becker et al.   PHARMACOGENOMICS JOURNAL

Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study

(2009) Trine Welløv Boesgaard et al.   PLoS One

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population

(2009) Cheng Hu et al.   PLoS One

Hepatocyte nuclear factor 1-alpha mutation in normal glucose-tolerant subjects and early-onset type 2 diabetic patients

(2009) Dong Mee Lim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

(2008) Dharambir K Sanghera et al.   BMC Medical Genetics

The association of adiponectin allele 45T/G and −11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients

(2008) Hong Sun et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

(2008) IS Song et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians

(2008) L. Ma et al.   DIABETES

Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies: A Population-Based Study

(2008) M. van Hoek et al.   DIABETES

Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes

(2008) N. Grarup et al.   DIABETES

Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

(2008) Y. Wu et al.   DIABETES

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

(2008) M. C.Y. Ng et al.   DIABETES

Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians

(2008) R. Rong et al.   DIABETES

Ser1369Ala Variant in Sulfonylurea Receptor Gene ABCC8 Is Associated With Antidiabetic Efficacy of Gliclazide in Chinese Type 2 Diabetic Patients

(2008) Y. Feng et al.   DIABETES CARE

Positive association between variations in CDKAL1 and type 2 diabetes in Han Chinese individuals

(2008) Y. Liu et al.   DIABETOLOGIA

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians

(2008) C. S. Yajnik et al.   DIABETOLOGIA

Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes

(2008) Martine Vaxillaire et al.   ENDOCRINE REVIEWS

Impact of genetic polymorphisms of leptin and TNF-α on rosiglitazone response in Chinese patients with type 2 diabetes

(2008) Hai-Ling Liu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Zinc Transporter-8 Gene (SLC30A8) Is Associated with Type 2 Diabetes in Chinese

(2008) Jie Xiang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population

(2008) Yong-Ho Lee et al.   JOURNAL OF HUMAN GENETICS

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

(2008) B. Emanuelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA