The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

Wnt signaling in development and disease

(2012) Yingzi Yang   Cell and Bioscience

Unraveling the role of FoxOs in bone—Insights from mouse models

(2011) Maria Almeida   BONE

A novel mechanism for the transcriptional regulation of Wnt signaling in development

(2011) T. Vacik et al.   GENES & DEVELOPMENT

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

(2011) D. Savic et al.   GENOME RESEARCH

TCF7L2 splice variants have distinct effects on β-cell turnover and function

(2011) Olivier Le Bacquer et al.   HUMAN MOLECULAR GENETICS

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

(2011) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

The genetics of type 2 diabetes: what have we learned from GWAS?

(2010) Liana K. Billings et al.   Annals of the New York Academy of Sciences

Wnt Signaling and Aging-Related Heart Disorders

(2010) Atsuhiko T. Naito et al.   CIRCULATION RESEARCH

The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

(2010) A. C. Alibegovic et al.   DIABETES

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

(2010) A. P. Gjesing et al.   DIABETOLOGIA

Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth

(2010) D. Dabelea et al.   DIABETOLOGIA

Can the Genetics of Type 1 and Type 2 Diabetes Shed Light on the Genetics of Latent Autoimmune Diabetes in Adults?

(2010) Struan F. A. Grant et al.   ENDOCRINE REVIEWS

Open chromatin and diabetes risk

(2010) Leif Groop   NATURE GENETICS

TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women

(2009) Marilyn C Cornelis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Wnt5b stimulates adipogenesis by activating PPARγ, and inhibiting the β-catenin dependent Wnt signaling pathway together with Wnt5a

(2009) F.H.J. van Tienen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in  -Cell Function

(2009) A. L. Gloyn et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

WNT/β-catenin increases the production of incretins by entero-endocrine cells

(2009) J. M. García-Martínez et al.   DIABETOLOGIA

Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice

(2009) J. Krützfeldt et al.   DIABETOLOGIA

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

(2009) K. Pilgaard et al.   DIABETOLOGIA

Tissue-specific alternative splicing of TCF7L2

(2009) Ludmila Prokunina-Olsson et al.   HUMAN MOLECULAR GENETICS

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes

(2009) Ludmila Prokunina-Olsson et al.   PLoS One

Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin

(2008) Maja Ahlzén et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

(2008) Tianru Jin et al.   CELLULAR SIGNALLING

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

(2008) M. C.Y. Ng et al.   DIABETES

WNT signalling is both an inducer and effector of glucagon-like peptide-1

(2008) B. Gustafson et al.   DIABETOLOGIA

The WNT signalling pathway and diabetes mellitus

(2008) T. Jin   DIABETOLOGIA

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population

(2008) J. L. González-Sánchez et al.   DIABETOLOGIA

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Cross Talk between the Insulin and Wnt Signaling Pathways: Evidence from Intestinal Endocrine L Cells

(2008) Fenghua Yi et al.   ENDOCRINOLOGY

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus

(2008) Tianru Jin et al.   MOLECULAR ENDOCRINOLOGY

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE