Pharmacogenomics of oral antidiabetic medications: current data and pharmacoepigenomic perspective

Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology Consensus Panel on Type 2 Diabetes Mellitus: An Algorithm for Glycemic Control

(2013) Helena Rodbard et al.   Endocrine Practice

Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

(2011) Andrea Caporali et al.   CIRCULATION

Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia

(2011) Andreas Holstein et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets

(2011) Deepti Ramachandran et al.   FEBS Journal

Type 2 Diabetes Mellitus: Managing Hemoglobin A1c and Beyond

(2011) Grant C. Fowler et al.   SOUTHERN MEDICAL JOURNAL

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

(2010) Lei Kong et al.   ACTA DIABETOLOGICA

The TCF7L2 Diabetes Risk Variant is Associated with HbA1C Levels: a Genome-Wide Association Meta-Analysis

(2010) Christopher S. Franklin et al.   ANNALS OF HUMAN GENETICS

SLCO1B1 Polymorphism and Oral Antidiabetic Drugs

(2010) Annikka Kalliokoski et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system

(2010) Magnus Ingelman-Sundberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin resistance at the crossroads of metabolic syndrome: Systemic analysis using microarrays

(2010) Eunjung Kim   Biotechnology Journal

MicroRNA signature of the human developing pancreas

(2010) Samuel Rosero et al.   BMC GENOMICS

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

(2010) Hemang Parikh et al.   BMC Medical Genomics

Epigenetics

(2010) Mark E. Cooper et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes

(2010) Z. Schroner et al.   DIABETES OBESITY & METABOLISM

Genetic variants of the insulin receptor substrate-1 are influencing the therapeutic efficacy of oral antidiabetics

(2010) A. Seeringer et al.   DIABETES OBESITY & METABOLISM

MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

(2010) Liang-Liang Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Nucleosome dynamics and epigenetic stability

(2010) Philipp Korber et al.   Essays in Biochemistry

Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

(2010) Inge A. M. van den Oever et al.   MEDIATORS OF INFLAMMATION

Common polymorphisms of the peroxisome proliferator-activated receptor–γ (Pro12Ala) and peroxisome proliferator-activated receptor–γ coactivator–1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus

(2010) Ming-Chia Hsieh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea

(2010) Matthijs L. Becker et al.   Pharmacogenetics and Genomics

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

(2010) Zhi-Jun Wang et al.   Pharmacogenetics and Genomics

ABCC8polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas

(2010) Ryosuke Sato et al.   PHARMACOGENOMICS

Effect ofCYP2C9polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus

(2010) Jesse J Swen et al.   PHARMACOGENOMICS

MicroRNAs and pharmacogenomics

(2010) Noam Shomron   PHARMACOGENOMICS

The past, present and future of pharmacoepigenomics

(2010) Magnus Ingelman-Sundberg et al.   PHARMACOGENOMICS

Personalized Prognosis and Diagnosis of Type 2 Diabetes – Vision or Fiction?

(2010) Günter Müller   PHARMACOLOGY

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort

(2010) Jie Wen et al.   PLoS One

High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression

(2010) Rikard G. Fred et al.   PLoS One

RNAi and small interfering RNAs in human disease therapeutic applications

(2010) Monica R. Lares et al.   TRENDS IN BIOTECHNOLOGY

The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells

(2010) Mugdha V. Joglekar et al.   Islets

A Brief Review on the Mechanisms of miRNA Regulation

(2010) Yimei Cai et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Human CYP2E1 is regulated by miR-378

(2009) Takuya Mohri et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetic control of gene expression

(2009) Tomas J. Ekström   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study

(2009) K Zhou et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics in diabetes

(2009) Ewan R. Pearson   Current Diabetes Reports

Genome-wide association studies in type 2 diabetes

(2009) Mark I. McCarthy et al.   Current Diabetes Reports

Oral Antidiabetic Agents: Anti-Atherosclerotic Properties Beyond Glucose Lowering?

(2009) N. Papanas et al.   CURRENT PHARMACEUTICAL DESIGN

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel

(2009) K. S.C. Hamming et al.   DIABETES

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population

(2009) F. Takeuchi et al.   DIABETES

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

(2009) H. Xie et al.   DIABETES

Metformin - the gold standard in type 2 diabetes: what does the evidence tell us?

(2009) E. Bosi   DIABETES OBESITY & METABOLISM

A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes

(2009) Hideichi MAKINO et al.   ENDOCRINE JOURNAL

The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects

(2009) Bo Tan et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Oral antidiabetic drug metabolism: pharmacogenomics and drug interactions

(2009) Andreas Holstein et al.   Expert Opinion on Drug Metabolism & Toxicology

The E23K Variant ofKCNJ11and the Risk for Severe Sulfonylurea-induced Hypoglycemia in Patients with Type 2 Diabetes

(2009) A. Holstein et al.   HORMONE AND METABOLIC RESEARCH

Epigenetic control

(2009) Geneviève P. Delcuve et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetics: Connecting Environment and Genotype to Phenotype and Disease

(2009) S.P. Barros et al.   JOURNAL OF DENTAL RESEARCH

Thiazolidinediones and clinical outcomes in type 2 diabetes

(2009) Ravi Retnakaran et al.   LANCET

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

(2009) Antonei B. Csoka et al.   MEDICAL HYPOTHESES

Epigenetic and microRNA-mediated regulation in diabetes

(2009) P. Muhonen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

(2009) Ying Chen et al.   Pharmacogenetics and Genomics

Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response

(2009) Matthijs L. Becker et al.   Pharmacogenetics and Genomics

Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein

(2009) Alvin Gomez et al.   PHARMACOGENOMICS

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine

(2009) Prasun J Mishra et al.   PHARMACOGENOMICS

Presence ofCYP2C9*3allele increases risk for hypoglycemia in Type 2 diabetic patients treated with sulfonylureas

(2009) Georgia Ragia et al.   PHARMACOGENOMICS

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

(2009) M L Becker et al.   PHARMACOGENOMICS JOURNAL

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

(2009) Ylva Edling et al.   TOXICOLOGY IN VITRO

Genetic variations in the pancreatic ATP-sensitive potassium channel, β-cell dysfunction, and susceptibility to type 2 diabetes

(2008) D. A. Chistiakov et al.   ACTA DIABETOLOGICA

Association ofKCNJ11andABCC8genetic polymorphisms with response to repaglinide in Chinese diabetic patients1

(2008) Ya-yi HE et al.   ACTA PHARMACOLOGICA SINICA

The cell biology of DNA methylation in mammals

(2008) Egor Prokhortchouk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The effect ofSLCO1B1polymorphism on repaglinide pharmacokinetics persists over a wide dose range

(2008) Annikka Kalliokoski et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Role of Advanced Glycation End Products (AGEs) and Oxidative Stress in Diabetic Retinopathy

(2008) Sho-ichi Yamagishi et al.   CURRENT PHARMACEUTICAL DESIGN

Interaction of Oral Antidiabetic Drugs With Hepatic Uptake Transporters: Focus on Organic Anion Transporting Polypeptides and Organic Cation Transporter 1

(2008) I. Bachmakov et al.   DIABETES

Ser1369Ala Variant in Sulfonylurea Receptor Gene ABCC8 Is Associated With Antidiabetic Efficacy of Gliclazide in Chinese Type 2 Diabetic Patients

(2008) Y. Feng et al.   DIABETES CARE

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

The influence of adiponectin gene polymorphism on the pioglitazone response in the Chinese with type 2 diabetes

(2008)   DIABETES OBESITY & METABOLISM

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Interindividual variability in oral antidiabetic drug disposition and response: the role of drug transporter polymorphisms

(2008) Michael A Pacanowski et al.   Expert Opinion on Drug Metabolism & Toxicology

MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

(2008) Mayrin Correa-Medina et al.   GENE EXPRESSION PATTERNS

DNA methylomes, histone codes and miRNAs: Tying it all together

(2008) Sònia Guil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Different Effects ofSLCO1B1Polymorphism on the Pharmacokinetics and Pharmacodynamics of Repaglinide and Nateglinide

(2008) Annikka Kalliokoski et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effect of the Pro12Ala polymorphism of the PPARγ2 gene on response to pioglitazone treatment in menopausal women

(2008) Mónica Ramírez-Salazar et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Minireview: The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus

(2008) Tianru Jin et al.   MOLECULAR ENDOCRINOLOGY

LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients

(2008) Eun Seok Kang et al.   MOLECULAR GENETICS AND METABOLISM

Organic cation transporters

(2008) G. Ciarimboli   XENOBIOTICA

No significant effect ofSLCO1B1polymorphism on the pharmacokinetics of rosiglitazone and pioglitazone

(2007) Annikka Kalliokoski et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY