Microglial Voltage-Gated Proton Channel Hv1 in Ischemic Stroke

Proton channel HVCN1 is required for effector functions of mouse eosinophils

(2013) Xiang Zhu et al.   BMC IMMUNOLOGY

Microglia: Key Elements in Neural Development, Plasticity, and Pathology

(2013) Ukpong B. Eyo et al.   Journal of Neuroimmune Pharmacology

Subunit Interactions during Cooperative Opening of Voltage-Gated Proton Channels

(2013) Feng Qiu et al.   NEURON

Voltage-Sensing Domain of Voltage-Gated Proton Channel Hv1 Shares Mechanism of Block with Pore Domains

(2013) Liang Hong et al.   NEURON

Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

(2013) Thomas E. DeCoursey   PHYSIOLOGICAL REVIEWS

Autoimmune disorder phenotypes inHvcn1-deficient mice

(2012) Mari Sasaki et al.   BIOCHEMICAL JOURNAL

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains

(2011) Yejie Shi et al.   JOURNAL OF NEUROCHEMISTRY

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Aspartate 112 is the selectivity filter of the human voltage-gated proton channel

(2011) Boris Musset et al.   NATURE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

The Pore of the Voltage-Gated Proton Channel

(2011) Thomas K. Berger et al.   NEURON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

SnapShot: Reactive Oxygen Intermediates (ROI)

(2010) Carl Nathan et al.   CELL

Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel

(2010) Polina V. Lishko et al.   CELL

Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T

(2010) David Iovannisci et al.   JOURNAL OF GENERAL PHYSIOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of Microglia Depends on Na+/H+ Exchange-Mediated H+ Homeostasis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1

(2010) I Scott Ramsey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

(2010) Dashdemberel Narantuya et al.   PLoS One

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Voltage-gated proton channel is expressed on phagosomes

(2009) Yoshifumi Okochi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

(2009) Antoun El Chemaly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis

(2009) D. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current

(2008) Anna De Simoni et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CLIC1 Function Is Required for  -Amyloid-Induced Generation of Reactive Oxygen Species by Microglia

(2008) R. H. Milton et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE

The Voltage-Gated Proton Channel Hv1 Has Two Pores, Each Controlled by One Voltage Sensor

(2008) Francesco Tombola et al.   NEURON

A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils

(2008) B. Musset et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1

(2008) S.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential contribution of a voltage-activated proton conductance to acid extrusion from rat hippocampal neurons

(2007) Y.M. Cheng et al.   NEUROSCIENCE