Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

Lipopolysaccharide-sensitive H+ current in dendritic cells

(2012) Kalina Szteyn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Homology Modeling-Simulation Protocol for Construction and Assessment of Hv1 Models

(2012) Kethika Kulleperuma et al.   BIOPHYSICAL JOURNAL

Clinicopathological and Biological Significance of Human Voltage-gated Proton Channel Hv1 Protein Overexpression in Breast Cancer

(2012) Yifan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOX5 in Human Spermatozoa

(2012) Boris Musset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Channelrhodopsin-2 Glu-90 Is Crucial for Ion Selectivity and Is Deprotonated during the Photocycle

(2012) Kirstin Eisenhauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Open-state stabilization in Kv channels: Voltage-sensor relaxation and pore propping by a bound ion

(2012) Robert J. French et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gating of the designed trimeric/tetrameric voltage-gated H+channel

(2012) Yuichiro Fujiwara et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals

(2012) K. A. Sutton et al.   MOLECULAR BIOLOGY AND EVOLUTION

Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of hydrogen bonds

(2012) Amir Golan et al.   Nature Chemistry

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells

(2012) Jin-Ho Song et al.   NEUROSCIENCE LETTERS

Zinc ions block H+/OH- channels in Chara australis

(2012) SABAH AL KHAZAALY et al.   PLANT CELL AND ENVIRONMENT

A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype

(2012) Pascal Gosselin-Badaroudine et al.   PLoS One

Tracking a complete voltage-sensor cycle with metal-ion bridges

(2012) U. Henrion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Voltage Gating in Potassium Channels

(2012) M. O. Jensen et al.   SCIENCE

Proton channels in algae: reasons to be excited

(2012) Alison R. Taylor et al.   TRENDS IN PLANT SCIENCE

The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1

(2012) Yuichiro Fujiwara et al.   Nature Communications

Strong glucose dependence of electron current in human monocytes

(2011) Boris Musset et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of Solvation Effects in Protein Denaturation: From Thermodynamics to Single Molecules and Back

(2011) Jeremy L. England et al.   Annual Review of Physical Chemistry

The Control of Male Fertility by Spermatozoan Ion Channels

(2011) Polina V. Lishko et al.   Annual Review of Physiology

Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis

(2011) Yifan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Contribution of S4 Charges to Gating Mechanism in Hv Channels

(2011) Carlos Gonzalez et al.   BIOPHYSICAL JOURNAL

A Theory for the Proton Transport of the Influenza Virus M2 Protein: Extensive Test against Conductance Data

(2011) Huan-Xiang Zhou   BIOPHYSICAL JOURNAL

Glu-286 Rotation and Water Wire Reorientation Are Unlikely the Gating Elements for Proton Pumping in Cytochrome c Oxidase

(2011) Shuo Yang et al.   BIOPHYSICAL JOURNAL

Antidepressants inhibit proton currents and tumor necrosis factor-α production in BV2 microglial cells

(2011) Jin-Ho Song et al.   BRAIN RESEARCH

R1 in the Shaker S4 occupies the gating charge transfer center in the resting state

(2011) Meng-chin A. Lin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Enhancement of Proton Conductance by Mutations of the Selectivity Filter of Aquaporin-1

(2011) Hui Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia

(2011) Tadashi Matsuura et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Do Hv1 proton channels regulate the ionic and redox homeostasis of phagosomes?

(2011) Antoun El Chemaly et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rediscovering sperm ion channels with the patch-clamp technique

(2011) Y. Kirichok et al.   MOLECULAR HUMAN REPRODUCTION

Sensitivity of coccolithophores to carbonate chemistry and ocean acidification

(2011) L. Beaufort et al.   NATURE

Aspartate 112 is the selectivity filter of the human voltage-gated proton channel

(2011) Boris Musset et al.   NATURE

The Pore of the Voltage-Gated Proton Channel

(2011) Thomas K. Berger et al.   NEURON

Algal and aquatic plant carbon concentrating mechanisms in relation to environmental change

(2011) John A. Raven et al.   PHOTOSYNTHESIS RESEARCH

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

(2011) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated proton channel in a dinoflagellate

(2011) S. M. E. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating charge movement in the voltage sensor of a sodium channel

(2011) V. Yarov-Yarovoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Voltage-Gated H+ Channel Underlying pH Homeostasis in Calcifying Coccolithophores

(2011) Alison R. Taylor et al.   PLOS BIOLOGY

Proton secretion in freshly excised sinonasal mucosa from asthma and sinusitis patients

(2010) Do-Yeon Cho et al.   American Journal of Rhinology & Allergy

A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein

(2010) Alexei L. Polishchuk et al.   BIOCHEMISTRY

Structural and energetic basis for H+ versus Na+ binding selectivity in ATP synthase Fo rotors

(2010) Alexander Krah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

F1F0-ATP synthases of alkaliphilic bacteria: Lessons from their adaptations

(2010) David B. Hicks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Functional reconstitution of influenza A M2(22–62)

(2010) Emily Peterson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The potential role of cobalt ions released from metal prosthesis on the inhibition of Hv1 proton channels and the decrease in Staphyloccocus epidermidis killing by human neutrophils

(2010) Samira Daou et al.   BIOMATERIALS

Simultaneous Measurement of Phagosome and Plasma Membrane Potentials in Human Neutrophils By Di-8-Anepps and SEER

(2010) Deri Morgan et al.   BIOPHYSICAL JOURNAL

Two Open States with Progressive Proton Selectivities in the Branched Channelrhodopsin-2 Photocycle

(2010) André Berndt et al.   BIOPHYSICAL JOURNAL

Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel

(2010) Polina V. Lishko et al.   CELL

Calcium-activated K+ channel (KCa3.1) activity during Ca2+ store depletion and store-operated Ca2+ entry in human macrophages

(2010) Ya-dong Gao et al.   CELL CALCIUM

Oligomerization of the voltage gated proton channel

(2010) Boris Musset et al.   Channels

Sieving experiments and pore diameter: it’s not a simple relationship

(2010) Daniel Krauss et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Molecular Mechanisms Underlying Calcification in Coccolithophores

(2010) Luke Mackinder et al.   GEOMICROBIOLOGY JOURNAL

The Role and Structure of the Carboxyl-terminal Domain of the Human Voltage-gated Proton Channel Hv1

(2010) Shu Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Reactivities of Cysteine Substitutions in Subunitaof ATP Synthase Define Residues Gating H+Transport from Each Side of the Membrane

(2010) Hui Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of amphipathic helical peptide denaturation by guanidinium chloride and urea: a molecular dynamics simulation study

(2010) Faramarz Mehrnejad et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T

(2010) David Iovannisci et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations

(2010) Stanislav Sokolov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Stimulus-dependent requirement of ion channels for microglial NADPH oxidase-mediated production of reactive oxygen species

(2010) Tom Schilling et al.   JOURNAL OF NEUROIMMUNOLOGY

Simulating Proton Transport through a Simplified Model for Trans-Membrane Proteins

(2010) Lynsey M. S. Shepherd et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Physiological roles of voltage-gated proton channels in leukocytes

(2010) Nicolas Demaurex et al.   JOURNAL OF PHYSIOLOGY-LONDON

Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating

(2010) Boris Musset et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanism of Fast Proton Transport along One-Dimensional Water Chains Confined in Carbon Nanotubes

(2010) Zhen Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1

(2010) I Scott Ramsey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes

(2010) Thomas E. DeCoursey   PHYSIOLOGY

A Single Amino Acid Change Converts the Sugar Sensor SGLT3 into a Sugar Transporter

(2010) Laura Bianchi et al.   PLoS One

Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes

(2010) Gábor L. Petheő et al.   PLoS One

A proton current drives action potentials in genetically identified sour taste cells

(2010) R. B. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton and cation transport activity of the M2 proton channel from influenza A virus

(2010) T. Leiding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1

(2010) Melania Capasso et al.   TRENDS IN CELL BIOLOGY

A New Type of Proton Coordination in an F1Fo-ATP Synthase Rotor Ring

(2010) Laura Preiss et al.   PLOS BIOLOGY

Essentials for ATP Synthesis by F1F0ATP Synthases

(2009) Christoph von Ballmoos et al.   Annual Review of Biochemistry

Electrophysiology of Reactive Oxygen Production in Signaling Endosomes

(2009) Fred S. Lamb et al.   ANTIOXIDANTS & REDOX SIGNALING

Voltage-gated proton channel is expressed on phagosomes

(2009) Yoshifumi Okochi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Co–Cr–Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: A role for osteocytes in particle-induced inflammation

(2009) Arihiko Kanaji et al.   BONE

Concerted action of two cation filters in the aquaporin water channel

(2009) Binghua Wu et al.   EMBO JOURNAL

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Identification of Thr29as a Critical Phosphorylation Site That Activates the Human Proton ChannelHvcn1in Leukocytes

(2009) Boris Musset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Roles of the His247and His281Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1

(2009) Ersin Selcuk Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

(2009) Antoun El Chemaly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temperature dependence of proton permeation through a voltage-gated proton channel

(2009) Miyuki Kuno et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional Hydration and Conformational Gating of Proton Uptake in Cytochrome c Oxidase

(2009) Rowan M. Henry et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Reconstitution of Purified Human Hv1 H+ Channels

(2009) Seok-Yong Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

NO MECHANISTIC DEPENDENCE OF PHOTOSYNTHESIS ON CALCIFICATION IN THE COCCOLITHOPHORIDEMILIANIA HUXLEYI(HAPTOPHYTA)

(2009) Nikos Leonardos et al.   JOURNAL OF PHYCOLOGY

Architecture and gating of Hv1 proton channels

(2009) Francesco Tombola et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein Profiling of Plasma Membranes Defines Aberrant Signaling Pathways in Mantle Cell Lymphoma

(2009) Robert S. Boyd et al.   MOLECULAR & CELLULAR PROTEOMICS

A Fluorescently Tagged C-Terminal Fragment of p47phox Detects NADPH Oxidase Dynamics during Phagocytosis

(2009) Xing Jun Li et al.   MOLECULAR BIOLOGY OF THE CELL

Strong cooperativity between subunits in voltage-gated proton channels

(2009) Carlos Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity

(2009) Francesco Tombola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis

(2009) D. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionality of the voltage-gated proton channel truncated in S4

(2009) S. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anomalous Proton Selectivity in a Large Channel:  Colicin A†

(2008) Stephen L. Slatin et al.   BIOCHEMISTRY

Voltage-gated proton channels

(2008) T. E. DeCoursey   CELLULAR AND MOLECULAR LIFE SCIENCES

The intimate and mysterious relationship between proton channels and NADPH oxidase

(2008) Boris Musset et al.   FEBS LETTERS

Cytochrome c oxidase: exciting progress and remaining mysteries

(2008) Peter Brzezinski et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants

(2008) Tomohiro Numata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus

(2008) Chunlong Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioluminescent response of individual dinoflagellate cells to hydrodynamic stress measured with millisecond resolution in a microfluidic device

(2008) M. I. Latz et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Orientational Dynamics of Water in the Nafion Polymer Electrolyte Membrane and Its Relationship to Proton Transport

(2008) Matt K. Petersen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Special Pair Dance and Partner Selection: Elementary Steps in Proton Transport in Liquid Water

(2008) Omer Markovitch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Voltage-gated proton channels: what's next?

(2008) Thomas E. DeCoursey   JOURNAL OF PHYSIOLOGY-LONDON

Detailed comparison of expressed and native voltage-gated proton channel currents

(2008) B. Musset et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

A Common Pathway for Charge Transport through Voltage-Sensing Domains

(2008) Baron Chanda et al.   NEURON

The Voltage-Gated Proton Channel Hv1 Has Two Pores, Each Controlled by One Voltage Sensor

(2008) Francesco Tombola et al.   NEURON

Protons and how they are transported by proton pumps

(2008) M. J. Buch-Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils

(2008) B. Musset et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimeric nature of voltage-gated proton channels

(2008) Hans P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1

(2008) S.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Nox2 in elimination of microorganisms

(2008) Balázs Rada et al.   Seminars in Immunopathology

Proton Transport through Influenza A Virus M2 Protein Reconstituted in Vesicles

(2007) J. Craig Moffat et al.   BIOPHYSICAL JOURNAL

Potential contribution of a voltage-activated proton conductance to acid extrusion from rat hippocampal neurons

(2007) Y.M. Cheng et al.   NEUROSCIENCE