Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2

(2012) Supun M. Bakmiwewa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase

(2012) Mee Young Chang et al.   CANCER BIOLOGY & THERAPY

Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation

(2012) Feng Qian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Whole-brain Radiation Therapy and Chloroquine in Patients With Brain Metastases: Outcomes and Response Related to IDO2 Gene Single-nucleotide Polymorphisms

(2012) H. Eldredge et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Studies on Tissue and Cellular Distribution of Indoleamine 2,3-Dioxygenase 2

(2012) Masakazu Fukunaga et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

(2011) David Meininger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase in basal cell carcinoma keratinocytes

(2011) B.K.K. Lo et al.   BRITISH JOURNAL OF DERMATOLOGY

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

(2011) J. Godin-Ethier et al.   CLINICAL CANCER RESEARCH

Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis*

(2011) Dechaboon Changsirivathanathamrong et al.   CRITICAL CARE MEDICINE

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection

(2011) Senad Divanovic et al.   JOURNAL OF INFECTIOUS DISEASES

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

(2011) Juliana Croitoru-Lamoury et al.   PLoS One

Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2

(2010) Christopher Jonathan Daraius Austin et al.   AMINO ACIDS

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

1-l-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-d-methyltryptophan

(2010) Hajime J. Yuasa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Deficient Tryptophan Catabolism along the Kynurenine Pathway Reveals That the Epididymis Is in a Unique Tolerogenic State

(2010) Aicha Jrad-Lamine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells

(2010) Ting Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis

(2009) Gabriel Criado et al.   ARTHRITIS AND RHEUMATISM

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

(2009) Feng Qian et al.   CANCER RESEARCH

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases

(2009) Hajime J. Yuasa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Reassessment of the Reaction Mechanism in the Heme Dioxygenases

(2009) Nishma Chauhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target

(2009) Agnieszka K. Witkiewicz et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

(2008) Antonio Macchiarulo et al.   AMINO ACIDS

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cytochromeb5, Not Superoxide Anion Radical, Is a Major Reductant of Indoleamine 2,3-Dioxygenase in Human Cells

(2008) Ghassan J. Maghzal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE