Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise

Mesenchymal Stem Cell Deformability and Implications for Microvascular Sequestration

(2018) Herbert H. Lipowsky et al.   ANNALS OF BIOMEDICAL ENGINEERING

Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells

(2018) Samantha F.H. de Witte et al.   STEM CELLS

Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system

(2017) Barbara Crivelli et al.   JOURNAL OF CONTROLLED RELEASE

Haplotype Counting for Sensitive Chimerism Testing

(2017) Marija Debeljak et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

(2017) Antonio Galleu et al.   Science Translational Medicine

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration

(2017) Franziska Nitzsche et al.   STEM CELLS

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

(2017) W. Nathaniel Brennen et al.   Oncotarget

Systemically Infused Mesenchymal Stem Cells Show Different Homing Profiles in Healthy and Tumor Mouse Models

(2017) Chengying Xie et al.   Stem Cells Translational Medicine

Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury

(2017) Jessica R. Perez et al.   Scientific Reports

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation

(2017) Bruna Corradetti et al.   Scientific Reports

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer

(2016) Oren Levy et al.   BIOMATERIALS

Genetically modified mesenchymal stromal cells in cancer therapy

(2016) Elizabeth K. Sage et al.   CYTOTHERAPY

Harnessing mesenchymal stem cell homing as an anticancer therapy

(2016) Anna Hagenhoff et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures

(2016) W. Nathaniel Brennen et al.   PROSTATE

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells

(2016) Brad Dykstra et al.   STEM CELLS

Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?

(2016) Ann De Becker et al.   World Journal of Stem Cells

Gadolinium-chelate nanoparticle entrapped human mesenchymal stem cell via photochemical internalization for cancer diagnosis

(2015) Kyoung Sub Kim et al.   BIOMATERIALS

Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

(2015) Naomi D’souza et al.   BMC Medicine

Effect of 17β-estradiol on mediators involved in mesenchymal stromal cell trafficking in cell therapy of diabetes

(2015) Solmaz Mirzamohammadi et al.   CYTOTHERAPY

The MSC curtain that stops the immune system

(2015) Arnold I. Caplan et al.   IMMUNOLOGY LETTERS

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

(2015) Augusto Pessina et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Suspension-Expansion of Bone Marrow Results in Small Mesenchymal Stem Cells Exhibiting Increased Transpulmonary Passage Following Intravenous Administration

(2015) Andrea Zanetti et al.   TISSUE ENGINEERING PART C-METHODS

A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells

(2015) Oren Levy et al.   Cell Reports

Pre-Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer

(2015) Chris L. Smith et al.   Stem Cells Translational Medicine

Adult Mesenchymal Stem Cells: When, Where, and How

(2015) Arnold I. Caplan   Stem Cells International

Novel 89Zr cell labeling approach for PET-based cell trafficking studies

(2015) Aditya Bansal et al.   EJNMMI Research

Engineering Enzymatically Activated “Molecular Grenades” for Cancer

(2015) Samuel R. Denmeade et al.   Oncotarget

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer

(2015) W. Nathaniel Brennen et al.   Oncotarget

Design Considerations of Iron-Based Nanoclusters for Noninvasive Tracking of Mesenchymal Stem Cell Homing

(2014) Xinglu Huang et al.   ACS Nano

Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient

(2014) Young-Wook Won et al.   BIOMATERIALS

Serum-free spheroid suspension culture maintains mesenchymal stem cell proliferation and differentiation potential

(2014) Stella Alimperti et al.   BIOTECHNOLOGY PROGRESS

Stem Cells Loaded With Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy

(2014) Matthias Duebgen et al.   JNCI-Journal of the National Cancer Institute

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

(2013) O. Levy et al.   BLOOD

Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity

(2013) A. Castleton et al.   BLOOD

Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment

(2013) W Nathaniel Brennen et al.   ENDOCRINE-RELATED CANCER

Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors

(2013) Jordi Martinez-Quintanilla et al.   STEM CELLS

Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

(2013) Darwin J. Prockop   STEM CELLS

Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics

(2012) Hao Cheng et al.   BIOMATERIALS

Real-Time Monitoring of Rare Circulating Hepatocellular Carcinoma Cells in an Orthotopic Model by In Vivo Flow Cytometry Assesses Resection on Metastasis

(2012) Z.-C. Fan et al.   CANCER RESEARCH

Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy

(2012) Donald G. Phinney   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Engineered cell homing

(2011) D. Sarkar et al.   BLOOD

The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity

(2011) S H Seo et al.   GENE THERAPY

Allogeneic mesenchymal stem cells: Agents of immune modulation

(2011) Karen English et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Image-guided, Tumor Stroma-targeted 131I Therapy of Hepatocellular Cancer After Systemic Mesenchymal Stem Cell-mediated NIS Gene Delivery

(2011) Kerstin Knoop et al.   MOLECULAR THERAPY

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

(2011) Darwin J Prockop et al.   MOLECULAR THERAPY

Early distribution of intravenously injected mesenchymal stem cells in rats with acute brain trauma evaluated by 99mTc-HMPAO labeling

(2011) Bok-Nam Park et al.   NUCLEAR MEDICINE AND BIOLOGY

In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis

(2011) Ali Gholamrezanezhad et al.   NUCLEAR MEDICINE AND BIOLOGY

Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy

(2011) Augusto Pessina et al.   PLoS One

Mesenchymal Stem Cell-Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer

(2011) Roisin M. Dwyer et al.   STEM CELLS

Long-Term Detection of Fluorescently Labeled Human Mesenchymal Stem Cell In Vitro and In Vivo by Semi-Automated Microscopy

(2011) Hans Polzer et al.   TISSUE ENGINEERING PART C-METHODS

Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1–induced Differentiation to Target Cancer Angiogenesis

(2010) Claudius Conrad et al.   ANNALS OF SURGERY

Targeting Improves MSC Treatment of Inflammatory Bowel Disease

(2010) In Kap Ko et al.   MOLECULAR THERAPY

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?

(2010) Ann H. Klopp et al.   STEM CELLS

Mesenchymal stem cell therapy: Two steps forward, one step back

(2010) James Ankrum et al.   TRENDS IN MOLECULAR MEDICINE

Targeting Tumor Stroma Using Engineered Mesenchymal Stem Cells Reduces the Growth of Pancreatic Carcinoma

(2009) Christoph Zischek et al.   ANNALS OF SURGERY

Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells

(2009) J L Dembinski et al.   CANCER GENE THERAPY

Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

(2009) M. R. Loebinger et al.   CANCER RESEARCH

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence

(2009) Jana Luetzkendorf et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth

(2009) Ilaria T Cavarretta et al.   MOLECULAR THERAPY

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging

(2009) Shannon Kidd et al.   STEM CELLS

The Role of Hypoxia in Bone Marrow–Derived Mesenchymal Stem Cells: Considerations for Regenerative Medicine Approaches

(2009) Ruud Das et al.   TISSUE ENGINEERING PART B-REVIEWS

Fate Of Culture-Expanded Mesenchymal Stem Cells in The Microvasculature

(2008) Catalin Toma et al.   CIRCULATION RESEARCH

Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model

(2008) C Ren et al.   GENE THERAPY

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

(2008) E Spaeth et al.   GENE THERAPY

Mesenchymal Stem Cells: Isolation, Characterisation and In Vivo Fluorescent Dye Tracking

(2008) Christopher Weir et al.   Heart Lung and Circulation

Bone Marrow Multipotent Mesenchymal Stroma Cells Act as Pericyte-like Migratory Vehicles in Experimental Gliomas

(2008) Daniel Bexell et al.   MOLECULAR THERAPY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT