Cysteine proteases as digestive enzymes in parasitic helminths

De novo assembly and characterization of the Trichuris trichiura adult worm transcriptome using Ion Torrent sequencing

(2016) Leonardo N. Santos et al.   ACTA TROPICA

A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis

(2016) Alessandra Ricciardi et al.   BMC INFECTIOUS DISEASES

The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates

(2016) Junfei Wei et al.   Parasites & Vectors

Immunocapture of circulating Schistosoma mansoni cathepsin B antigen (Sm31) by anti-Sm31 polyclonal antibodies

(2016) Amelia Y. González et al.   PARASITOLOGY INTERNATIONAL

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria

(2016) Louise S. Goupil et al.   PLoS Neglected Tropical Diseases

Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes

(2015) J. D. Ward   GENETICS

Influence of immunoprotection on genetic variability of cysteine proteinases from Haemonchus contortus adult worms

(2015) S. Martín et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis

(2015) Wenjun Chen et al.   Parasites & Vectors

Fasciola hepatica vaccine: We may not be there yet but we’re on the right road

(2015) Verónica Molina-Hernández et al.   VETERINARY PARASITOLOGY

Peptidases Compartmentalized to the Ascaris suum Intestinal Lumen and Apical Intestinal Membrane

(2015) Douglas P. Jasmer et al.   PLoS Neglected Tropical Diseases

The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution

(2015) Krystyna Cwiklinski et al.   GENOME BIOLOGY

Immunolocalization and developmental expression patterns of two cathepsin B proteases (AC-cathB-1, -2) of Angiostrongylus cantonensis

(2014) Changmao Yu et al.   EXPERIMENTAL PARASITOLOGY

Molecular Epidemiology of Ascariasis: A Global Perspective on the Transmission Dynamics of Ascaris in People and Pigs

(2014) Martha Betson et al.   JOURNAL OF INFECTIOUS DISEASES

Cysteine proteinase genes in Indian strain of Haemonchus contortus

(2014) I.M. Allaie et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction

(2014) Bernardo J Foth et al.   NATURE GENETICS

Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity

(2014) Rashika El Ridi et al.   PLoS One

Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch

(2014) Adéla Jílková et al.   STRUCTURE

Systems Biology Studies of Adult Paragonimus Lung Flukes Facilitate the Identification of Immunodominant Parasite Antigens

(2014) Samantha N. McNulty et al.   PLoS Neglected Tropical Diseases

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

(2013) Momar Ndao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of Parasitic Schistosoma mansoni Cysteine Peptidase by Vinyl Sulfone Inhibitors

(2013) Jindřich Fanfrlík et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Adult somatic stem cells in the human parasite Schistosoma mansoni

(2013) James J. Collins III et al.   NATURE

A proteomic approach to identify proteins fromTrichuris trichiuraextract with immunomodulatory effects

(2013) L. N. Santos et al.   PARASITE IMMUNOLOGY

Penetration ofTrichobilharziacercariae into mammals: dangerous or negligible event?

(2013) P. Horák et al.   Parasite

Identification and characterization of the second cysteine protease inhibitor of Clonorchis sinensis (CsStefin-2)

(2013) Jung-Mi Kang et al.   PARASITOLOGY RESEARCH

The Carcinogenic Liver Fluke, Clonorchis sinensis: New Assembly, Reannotation and Analysis of the Genome and Characterization of Tissue Transcriptomes

(2013) Yan Huang et al.   PLoS One

Cloning and characterization of a cathepsin L-like cysteine protease from Taenia pisiformis

(2013) Qiuxia Wang et al.   VETERINARY PARASITOLOGY

It's No Fluke: The Planarian as a Model for Understanding Schistosomes

(2013) James J. Collins et al.   PLoS Pathogens

Cathepsin B-like and hemoglobin-type cysteine proteases: Stage-specific gene expression in Angiostrongy cantonensis

(2012) Fang Ni et al.   EXPERIMENTAL PARASITOLOGY

Whole-genome sequence of Schistosoma haematobium

(2012) Neil D Young et al.   NATURE GENETICS

Considering RNAi experimental design in parasitic helminths

(2012) JOHNATHAN J. DALZELL et al.   PARASITOLOGY

Cloning and characterization of a novel cathepsin B-like cysteine proteinase from Angiostrongylus cantonensis

(2012) Mei Cheng et al.   PARASITOLOGY RESEARCH

Cure of Hookworm Infection with a Cysteine Protease Inhibitor

(2012) Jon J. Vermeire et al.   PLoS Neglected Tropical Diseases

Serine Protease(s) Secreted by the Nematode Trichuris muris Degrade the Mucus Barrier

(2012) Sumaira Z. Hasnain et al.   PLoS Neglected Tropical Diseases

Mapping the Pro-Peptide of theSchistosoma mansoniCathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors

(2011) Martin Horn et al.   ACS Chemical Biology

The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling

(2011) J. C. Rink et al.   DEVELOPMENT

A regulatory program for excretory system regeneration in planarians

(2011) M. L. Scimone et al.   DEVELOPMENT

Characterization of Angiostrongylus cantonensis excretory–secretory proteins as potential diagnostic targets

(2011) Alessandra L. Morassutti et al.   EXPERIMENTAL PARASITOLOGY

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke,Schistosoma mansoni

(2011) Adéla Jílková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and functional characterization of CsStefin-1, a cysteine protease inhibitor of Clonorchis sinensis

(2011) Jung-Mi Kang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Ascaris suum draft genome

(2011) Aaron R. Jex et al.   NATURE

Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis

(2011) Wenjun Chen et al.   Parasites & Vectors

Clonorchis sinensis and clonorchiasis, an update

(2011) Sung-Tae Hong et al.   PARASITOLOGY INTERNATIONAL

Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasis

(2011) Xiaoli Lv et al.   PARASITOLOGY RESEARCH

Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis

(2011) Yan-ping Han et al.   PARASITOLOGY RESEARCH

Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory–secretory antigen-fructose-1,6-bisphosphatase

(2011) Minghui Zheng et al.   PARASITOLOGY RESEARCH

An eye on RNAi in nematode parasites

(2011) Aaron G. Maule et al.   TRENDS IN PARASITOLOGY

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

(2011) Mark W. Robinson et al.   PLoS Neglected Tropical Diseases

Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, Clonorchis sinensis

(2011) Won Gi Yoo et al.   PLoS Neglected Tropical Diseases

Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles

(2010) Luke J. Norbury et al.   BIOCHIMIE

Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites

(2010) Mark S. Pearson et al.   BIOLOGICAL CHEMISTRY

Echinococcus multilocularis: Identification and functional characterization of cathepsin B-like peptidases from metacestode

(2010) Yasuhito Sako et al.   EXPERIMENTAL PARASITOLOGY

Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle

(2010) Kateřina Dolečková et al.   PARASITOLOGY RESEARCH

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

(2010) Saša Štefanić et al.   PLoS Neglected Tropical Diseases

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

(2009) Sheila Donnelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Degradation of Hemoglobin in the Intestine of the Human HookwormNecator americanus

(2009) Najju Ranjit et al.   JOURNAL OF INFECTIOUS DISEASES

The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen

(2009) Ileana Corvo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A family of cathepsin F cysteine proteases of Clonorchis sinensis is the major secreted proteins that are expressed in the intestine of the parasite

(2009) Jung-Mi Kang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Detection of the Sm31 antigen in sera of Schistosoma mansoni– infected patients from a low endemic area

(2009) G. S. SULBARÁN et al.   PARASITE IMMUNOLOGY

Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis

(2009) Yanwen Li et al.   PARASITOLOGY RESEARCH

Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products ofClonorchis sinensisadult worms

(2009) Jung-Won Ju et al.   PROTEOMICS

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

(2009) Jonathan Lowther et al.   PLoS Neglected Tropical Diseases

SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni

(2009) Jan Dvořák et al.   PLoS Neglected Tropical Diseases

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo

(2008) Greice Krautz-Peterson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus

(2008) Najju Ranjit et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Helminth pathogen cathepsin proteases: it’s a family affair

(2008) M ROBINSON et al.   TRENDS IN BIOCHEMICAL SCIENCES

The enigmatic asparaginyl endopeptidase of helminth parasites

(2008) John P. Dalton et al.   TRENDS IN PARASITOLOGY

Differential use of protease families for invasion by schistosome cercariae

(2007) Jan Dvořák et al.   BIOCHIMIE

The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration

(2007) L MCGONIGLE et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

CsCF-6, a novel cathepsin F-like cysteine protease for nutrient uptake of Clonorchis sinensis

(2007) Byoung-Kuk Na et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY