Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke,Schistosoma mansoni

Mapping the Pro-Peptide of theSchistosoma mansoniCathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors

(2011) Martin Horn et al.   ACS Chemical Biology

Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B

(2010) Jittiyawadee Sripa et al.   CELLULAR MICROBIOLOGY

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

(2010) Iain D. Kerr et al.   PLoS Neglected Tropical Diseases

In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

(2010) Yen Ting Chen et al.   PLoS Neglected Tropical Diseases

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

(2010) Saša Štefanić et al.   PLoS Neglected Tropical Diseases

Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

(2009) Martin Horn et al.   CHEMISTRY & BIOLOGY

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

(2009) Iain D. Kerr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semiempirical Quantum Chemical PM6 Method Augmented by Dispersion and H-Bonding Correction Terms Reliably Describes Various Types of Noncovalent Complexes

(2009) Jan Řezáč et al.   Journal of Chemical Theory and Computation

A Transferable H-Bonding Correction for Semiempirical Quantum-Chemical Methods

(2009) Martin Korth et al.   Journal of Chemical Theory and Computation

Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

(2009) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two approaches to discovering and developing new drugs for Chagas disease

(2009) JH McKerrow et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni

(2009) Conor R. Caffrey et al.   PLoS One

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

(2009) Jonathan Lowther et al.   PLoS Neglected Tropical Diseases

SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni

(2009) Jan Dvořák et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Development of protease inhibitors for protozoan infections

(2008) James H McKerrow et al.   CURRENT OPINION IN INFECTIOUS DISEASES

A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus

(2008) Najju Ranjit et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

(2007) Priyadarshini Jaishankar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS