Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites

Neutralizing Antibodies to the Hookworm HemoglobinaseNa‐APR‐1: Implications for a Multivalent Vaccine against Hookworm Infection and Schistosomiasis

(2010) Mark S. Pearson et al.   JOURNAL OF INFECTIOUS DISEASES

Transcriptional Changes in Schistosoma mansoni during Early Schistosomula Development and in the Presence of Erythrocytes

(2010) Geoffrey N. Gobert et al.   PLoS Neglected Tropical Diseases

Elucidating the transcriptome of Fasciola hepatica — A key to fundamental and biotechnological discoveries for a neglected parasite

(2009) Neil D. Young et al.   BIOTECHNOLOGY ADVANCES

An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

(2009) Mark S. Pearson et al.   FASEB JOURNAL

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

(2009) Simone A. Beckham et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Proteolytic Degradation of Hemoglobin in the Intestine of the Human HookwormNecator americanus

(2009) Najju Ranjit et al.   JOURNAL OF INFECTIOUS DISEASES

Excretory/Secretory Proteome of the Adult Developmental Stage of Human Blood Fluke,Schistosoma japonicum

(2009) Feng Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

The Schistosoma japonicum genome reveals features of host–parasite interplay

(2009)   NATURE

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products ofClonorchis sinensisadult worms

(2009) Jung-Won Ju et al.   PROTEOMICS

A Comparative Study of the Spatial Distribution of Schistosomiasis in Mali in 1984–1989 and 2004–2006

(2009) Archie C. A. Clements et al.   PLoS Neglected Tropical Diseases

A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica

(2008) Martín Cancela et al.   BIOCHIMIE

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis

(2008) Peter J Hotez et al.   Expert Review of Vaccines

Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: Functional expression, immunolocalization and subsite specificity

(2008) Sutas Suttiprapa et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth PathogenFasciola hepatica

(2008) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm,Ancylostoma caninum

(2008) Jason Mulvenna et al.   MOLECULAR & CELLULAR PROTEOMICS

A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus

(2008) Najju Ranjit et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The secretome of the filarial parasite, Brugia malayi: Proteomic profile of adult excretory–secretory products

(2008) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

New drugs for an ancient parasite

(2008) Alex Loukas et al.   NATURE MEDICINE

Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens

(2008) Ramamoorthi Jayaraj et al.   VETERINARY PARASITOLOGY

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus

(2007) Shuhua Xiao et al.   EXPERIMENTAL PARASITOLOGY

The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration

(2007) L MCGONIGLE et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade

(2007) Maria E. Morales et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis☆

(2007) Daniel Acosta et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY