Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

(2017) Winnie S. Liang et al.   GENOME RESEARCH

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

The genomic landscape of cutaneous melanoma

(2016) Tongwu Zhang et al.   Pigment Cell & Melanoma Research

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

(2016) Amy K. LeBlanc et al.   Science Translational Medicine

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

(2015) Ingegerd Elvers et al.   GENOME RESEARCH

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis

(2015) K Spring et al.   ONCOGENE

Comparative oncology: what dogs and other species can teach us about humans with cancer

(2015) Joshua D. Schiffman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

BRAF Mutations in Canine Cancers

(2015) Hiroyuki Mochizuki et al.   PLoS One

Genetic inactivation of TRAF3 in canine and human B-cell lymphoma

(2014) K. R. Bushell et al.   BLOOD

Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer

(2014) D. Liu et al.   CANCER RESEARCH

Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor

(2014) Kathleen Spring et al.   CELLULAR SIGNALLING

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

(2014) Rachael Thomas et al.   CHROMOSOME RESEARCH

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

(2014) Kelsey Poorman et al.   CHROMOSOME RESEARCH

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

(2014) C. Khanna et al.   CLINICAL CANCER RESEARCH

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis

(2014) Simon J. Furney et al.   Pigment Cell & Melanoma Research

Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs

(2013) Alexis Christoforides et al.   BMC GENOMICS

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma

(2013) Simon J Furney et al.   JOURNAL OF PATHOLOGY

The genomic signature of dog domestication reveals adaptation to a starch-rich diet

(2013) Erik Axelsson et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Long insert whole genome sequencing for copy number variant and translocation detection

(2013) Winnie S. Liang et al.   NUCLEIC ACIDS RESEARCH

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Cancer driver–passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer

(2013) J Tang et al.   ONCOGENE

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

(2013) R. Mark Simpson et al.   Pigment Cell & Melanoma Research

Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas

(2013) Marc Gillard et al.   Pigment Cell & Melanoma Research

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma

(2013) J. S. Fowles et al.   Veterinary and Comparative Oncology

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

DELLY: structural variant discovery by integrated paired-end and split-read analysis

(2012) T. Rausch et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ

(2012) R. Godfrey et al.   BLOOD

Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma

(2012) D. Hirsch et al.   CANCER RESEARCH

Chromothripsis and Human Disease: Piecing Together the Shattering Process

(2012) Christopher A. Maher et al.   CELL

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential

(2012) N. L. Solimini et al.   SCIENCE

KIT gene exon 11 mutations in canine malignant melanoma

(2012) Pei-Yi Chu et al.   VETERINARY JOURNAL

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

(2012) Andrea Y. Angstadt et al.   Cancer Genetics

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms

(2011) J. Armando Villamil et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling

(2011) Deepika Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas

(2011) A. Murakami et al.   Veterinary and Comparative Oncology

Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping

(2011) Amaury Vaysse et al.   PLoS Genetics

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility

(2010) Astrid Petermann et al.   BRAIN PATHOLOGY

Role of PTPRJ genotype in papillary thyroid carcinoma risk

(2010) Rodolfo Iuliano et al.   ENDOCRINE-RELATED CANCER

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunohistochemical Diagnosis of Canine Oral Amelanotic Melanocytic Neoplasms

(2010) R. C. Smedley et al.   VETERINARY PATHOLOGY

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

An Unbiased Screen Identifies DEP-1 Tumor Suppressor as a Phosphatase Controlling EGFR Endocytosis

(2009) Gabi Tarcic et al.   CURRENT BIOLOGY

Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases

(2009) Francesca Sacco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers

(2009) Yuichiro Mita et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer Incidence in Pet Dogs: Findings of the Animal Tumor Registry of Genoa, Italy

(2009) D.F. Merlo et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTPRJ Haplotypes and Colorectal Cancer Risk

(2008) A. E. Toland et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Head and neck mucosal melanoma: Experience with 42 patients, with emphasis on the role of postoperative radiotherapy

(2008) Marco Meleti et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Aberrant splicing of thePTPRDgene mimics microdeletions identified at this locus in neuroblastomas

(2007) Prakash Nair et al.   GENES CHROMOSOMES & CANCER