Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Inadequate brain glycogen or sleep increases spreading depression susceptibility

(2018) Kivilcim Kilic et al.   ANNALS OF NEUROLOGY

Glycogenolysis, an Astrocyte-Specific Reaction, is Essential for Both Astrocytic and Neuronal Activities Involved in Learning

(2018) Leif Hertz et al.   NEUROSCIENCE

The effects of aging on neuropil structure in mouse somatosensory cortex—A 3D electron microscopy analysis of layer 1

(2018) Corrado Calì et al.   PLoS One

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans

(2017) Andrew H. Song et al.   JOURNAL OF NEUROSCIENCE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

(2017) Emil Jakobsen et al.   NEUROCHEMICAL RESEARCH

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

(2017) Takashi Matsui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond

(2017) Shayne Mason   Frontiers in Neuroscience

Decreased Glycogen Content Might Contribute to Chronic Stress-Induced Atrophy of Hippocampal Astrocyte volume and Depression-like Behavior in Rats

(2017) Yunan Zhao et al.   Scientific Reports

Locus coeruleus: From global projection system to adaptive regulation of behavior

(2016) G. Aston-Jones et al.   BRAIN RESEARCH

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Astroglia dynamics in ageing and Alzheimer's disease

(2016) Alexei Verkhratsky et al.   CURRENT OPINION IN PHARMACOLOGY

Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns

(2016) Yuki Oe et al.   GLIA

Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

(2016) Maxime O. Baud et al.   JOURNAL OF SLEEP RESEARCH

Regulation of neuron–astrocyte metabolic coupling across the sleep–wake cycle

(2016) J.-M. Petit et al.   NEUROSCIENCE

Astrocytes: Orchestrating synaptic plasticity?

(2016) M. De Pittà et al.   NEUROSCIENCE

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology?

(2016) Crhistian L. Bender et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

(2016) Hennariikka Koivisto et al.   Frontiers in Aging Neuroscience

Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice

(2016) Cathy Joanna Jensen et al.   PLoS One

Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism

(2015) Anna Falkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

(2015) Corrado Calì et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Brain glycogen in health and disease

(2015) Jordi Duran et al.   MOLECULAR ASPECTS OF MEDICINE

Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine

(2015) B Boury-Jamot et al.   MOLECULAR PSYCHIATRY

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

(2015) Renaud Jolivet et al.   PLoS Computational Biology

Functional impact of glycogen degradation on astrocytic signalling: Figure 1

(2014) Margit S. Müller   BIOCHEMICAL SOCIETY TRANSACTIONS

Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding

(2014) Britton W. Boras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain glycogen: emergency fuel and dynamic function in neurotransmission

(2014) Anne B. Walls et al.   METABOLIC BRAIN DISEASE

Astrocytic glycogenolysis: mechanisms and functions

(2014) Leif Hertz et al.   METABOLIC BRAIN DISEASE

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

(2014) Xue Xue et al.   NANO LETTERS

Basic Mechanism Leading to Stimulation of Glycogenolysis by Isoproterenol, EGF, Elevated Extracellular K+ Concentrations, or GABA

(2014) Junnan Xu et al.   NEUROCHEMICAL RESEARCH

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Contribution of glycogen in supporting axon conduction in the peripheral and central nervous systems: the role of lactate

(2014) Tom W. Chambers et al.   Frontiers in Neuroscience

Volume transmission and its different forms in the central nervous system

(2013) Kjell Fuxe et al.   Chinese Journal of Integrative Medicine

Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain

(2013) Jordi Duran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

(2013) Marco Conti et al.   JOURNAL OF GENERAL PHYSIOLOGY

Advanced glycation end-products disrupt the blood–brain barrier by stimulating the release of transforming growth factor–β by pericytes and vascular endothelial growth factor and matrix metalloproteinase–2 by endothelial cells in vitro

(2013) Fumitaka Shimizu et al.   NEUROBIOLOGY OF AGING

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Astrocytic and neuronal accumulation of elevated extracellular K+ with a 2/3 K+/Na+ flux ratio—consequences for energy metabolism, osmolarity and higher brain function

(2013) Leif Hertz et al.   Frontiers in Computational Neuroscience

Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism

(2012) Jun-hong Dong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Rapid Turnover of Glycogen in Memory Formation

(2012) Marie E. Gibbs et al.   NEUROCHEMICAL RESEARCH

The Role of Astrocytic Glycogen in Supporting the Energetics of Neuronal Activity

(2012) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain

(2012) Junnan Xu et al.   NEUROCHEMICAL RESEARCH

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks

(2012) Kjell Fuxe et al.   Frontiers in Physiology

Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data

(2011) Seda Genc et al.   BMC Systems Biology

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Noninvasive measurement of brain glycogen by nuclear magnetic resonance spectroscopy and its application to the study of brain metabolism

(2011) Nolawit Tesfaye et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contribution of astrocyte glycogen stores to progression of spreading depression and related events in hippocampal slices

(2011) J.L. Seidel et al.   NEUROSCIENCE

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

(2011) Suzie Lavoie et al.   PLoS One

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis

(2011) Ke Xu et al.   PLoS Computational Biology

Neuron-glia metabolic coupling and plasticity

(2010) Pierre J. Magistretti   EXPERIMENTAL PHYSIOLOGY

Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and [Ca2+]i

(2010) Leif Hertz et al.   NEUROCHEMISTRY INTERNATIONAL

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for α- and β-adrenergic receptors

(2010) M.E. Gibbs et al.   NEUROSCIENCE

Functional Importance of the Astrocytic Glycogen-Shunt and Glycolysis for Maintenance of an Intact Intra/Extracellular Glutamate Gradient

(2010) Arne Schousboe et al.   NEUROTOXICITY RESEARCH

Glucose and lactate supply to the synapse

(2009) L. Felipe Barros et al.   BRAIN RESEARCH REVIEWS

Glycogen Metabolism as a Marker of Astrocyte Differentiation

(2009) JF Brunet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements

(2009) Mathieu Cloutier et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Functional significance of brain glycogen in sustaining glutamatergic neurotransmission

(2009) Helle M. Sickmann et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity

(2008) Anne B. Walls et al.   JOURNAL OF NEUROCHEMISTRY

Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents

(2008) A.B. Walls et al.   NEUROSCIENCE

Astrocytic involvement in learning and memory consolidation

(2008) Marie E. Gibbs et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS