Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

PDE4B mediates local feedback regulation of  1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes

(2014) D. Mika et al.   JOURNAL OF CELL SCIENCE

β1-adrenergic receptor antagonists signal via PDE4 translocation

(2013) Wito Richter et al.   EMBO REPORTS

Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia

(2013) E. I. Charych et al.   JOURNAL OF NEUROSCIENCE

Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells

(2011) Wei P. Feinstein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Emerging themes of cAMP regulation of the pulmonary endothelial barrier

(2011) Sarah L. Sayner   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current

(2011) Sanja Beca et al.   CIRCULATION RESEARCH

PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts

(2011) Brigitte E. Blackman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

(2011) Jérôme Leroy et al.   JOURNAL OF CLINICAL INVESTIGATION

Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4)

(2011) Jonathan P. Day et al.   JOURNAL OF MEDICINAL CHEMISTRY

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells

(2011) Sebastian Börner et al.   Nature Protocols

Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier

(2010) Bing Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

(2010) Michelle L Halls et al.   EMBO JOURNAL

The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations

(2010) Rodrigo F. Oliveira et al.   PLoS One

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Differential Association of Phosphodiesterase 4D Isoforms with β2-Adrenoceptor in Cardiac Myocytes

(2009) Vania De Arcangelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

(2009) Cecile Terrenoire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks

(2008) Susana R. Neves et al.   CELL

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

(2008) Giulietta Di Benedetto et al.   CIRCULATION RESEARCH

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL