The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer

Exploiting Conformational Ensembles in Modeling Protein–Protein Interactions on the Proteome Scale

(2013) Guray Kuzu et al.   JOURNAL OF PROTEOME RESEARCH

Large-scale mapping of human protein interactome using structural complexes

(2012) Manoj Tyagi et al.   EMBO REPORTS

Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases

(2012) Kosuke Hashimoto et al.   HUMAN MUTATION

A Strategy Based on Protein–Protein Interface Motifs May Help in Identifying Drug Off-Targets

(2012) H. Billur Engin et al.   Journal of Chemical Information and Modeling

Enriching the human apoptosis pathway by predicting the structures of protein–protein complexes

(2012) Saliha Ece Acuner Ozbabacan et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure-based prediction of protein–protein interactions on a genome-wide scale

(2012) Qiangfeng Cliff Zhang et al.   NATURE

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Interactome3D: adding structural details to protein networks

(2012) Roberto Mosca et al.   NATURE METHODS

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

(2012) A. Garai et al.   Science Signaling

A graphical interface for the FoldX forcefield

(2011) J. Van Durme et al.   BIOINFORMATICS

Protein-protein interaction sites are hot spots for disease-associated nonsynonymous SNPs

(2011) Alessia David et al.   HUMAN MUTATION

Human Proteome-scale Structural Modeling of E2–E3 Interactions Exploiting Interface Motifs

(2011) Gozde Kar et al.   JOURNAL OF PROTEOME RESEARCH

Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor  2 Expression

(2011) Y.-H. Ahn et al.   MOLECULAR AND CELLULAR BIOLOGY

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

(2011) Nurcan Tuncbag et al.   Nature Protocols

HotRegion: a database of predicted hot spot clusters

(2011) E. Cukuroglu et al.   NUCLEIC ACIDS RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Autoinflammatory Diseases: Clinical and Genetic Advances

(2010) S. Farasat et al.   ARCHIVES OF DERMATOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

ModBase, a database of annotated comparative protein structure models, and associated resources

(2010) U. Pieper et al.   NUCLEIC ACIDS RESEARCH

FiberDock: a web server for flexible induced-fit backbone refinement in molecular docking

(2010) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

(2009) Michael Ryan et al.   BIOINFORMATICS

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Infections and cancer: Established associations and new hypotheses

(2008) Catherine de Martel et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Architectures and Functional Coverage of Protein–Protein Interfaces

(2008) Nurcan Tuncbag et al.   JOURNAL OF MOLECULAR BIOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE