Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor  2 Expression

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

(2010) Takashi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

The Mitogen-Activated Protein Kinase Kinase 4 Has a Pro-Oncogenic Role in Skin Cancer

(2010) K. G. Finegan et al.   CANCER RESEARCH

Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility

(2010) Atsushi Nakajima et al.   CANCER SCIENCE

Loss of MKK4 expression in ovarian cancer: A potential role for the epithelial to mesenchymal transition

(2010) Shamima Yeasmin et al.   INTERNATIONAL JOURNAL OF CANCER

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

MKK4/SEK1 Is Negatively Regulated through a Feedback Loop Involving the E3 Ubiquitin Ligase Itch

(2009) Young-Ho Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

(2009) William Y. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity

(2009) M-C Liang et al.   ONCOGENE

Cancer driver mutations in protein kinase genes

(2008) Ali Torkamani et al.   CANCER LETTERS

Pten Inactivation Accelerates Oncogenic K-ras-Initiated Tumorigenesis in a Mouse Model of Lung Cancer

(2008) K. Iwanaga et al.   CANCER RESEARCH

c-Jun NH2-Terminal Kinase Activating Kinase 1/Mitogen-Activated Protein Kinase Kinase 4-Mediated Inhibition of SKOV3ip.1 Ovarian Cancer Metastasis Involves Growth Arrest and p21 Up-regulation

(2008) T. Lotan et al.   CANCER RESEARCH

Design and analysis issues in genome-wide somatic mutation studies of cancer

(2008) Giovanni Parmigiani et al.   GENOMICS

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer Prognosis

(2008) Chad J. Creighton et al.   JOURNAL OF CLINICAL ONCOLOGY