Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases

Predicting folding free energy changes upon single point mutations

(2012) Zhe Zhang et al.   BIOINFORMATICS

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations

(2011) Jian-Min Chen et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

In Silico and In Vitro Investigations of the Mutability of Disease-Causing Missense Mutation Sites in Spermine Synthase

(2011) Zhe Zhang et al.   PLoS One

The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

(2011) Anshuman Dixit et al.   PLoS One

BioRuby: bioinformatics software for the Ruby programming language

(2010) N. Goto et al.   BIOINFORMATICS

Computational analysis of missense mutations causing Snyder-Robinson syndrome

(2010) Zhe Zhang et al.   HUMAN MUTATION

Performance of protein stability predictors

(2010) Sofia Khan et al.   HUMAN MUTATION

Database resources of the National Center for Biotechnology Information

(2010) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH

Insights into protein kinase regulation and inhibition by large scale structural comparison

(2009) Jeyanthy Eswaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability

(2009) Anshuman Dixit et al.   BIOPHYSICAL JOURNAL

Modeling Effects of Human Single Nucleotide Polymorphisms on Protein-Protein Interactions

(2009) Shaolei Teng et al.   BIOPHYSICAL JOURNAL

Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non-Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials

(2009) D. M. Jackman et al.   CLINICAL CANCER RESEARCH

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Closely spaced multiple mutations as potential signatures of transient hypermutability in human genes

(2009) Jian-Min Chen et al.   HUMAN MUTATION

Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations

(2009) I. Y.-S. Tam et al.   MOLECULAR CANCER THERAPEUTICS

Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ

(2009) Jana E. Stone et al.   NUCLEIC ACIDS RESEARCH

Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases

(2009) Anshuman Dixit et al.   PLoS One

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details

(2009) V. Potapov et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cancer-associated mutations are preferentially distributed in protein kinase functional sites

(2009) Jose M. G. Izarzugaza et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

(2009) Anshuman Dixit et al.   PLoS Computational Biology

Recent developments in the MAFFT multiple sequence alignment program

(2008) K. Katoh et al.   BRIEFINGS IN BIOINFORMATICS

Cancer driver mutations in protein kinase genes

(2008) Ali Torkamani et al.   CANCER LETTERS

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Disruption of the EGFR E884–R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

(2008) Z Tang et al.   ONCOGENE

Epidemiology of Doublet/Multiplet Mutations in Lung Cancers: Evidence that a Subset Arises by Chronocoordinate Events

(2008) Zhenbin Chen et al.   PLoS One

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein interactions in human genetic diseases

(2008) Benjamin Schuster-Böckler et al.   GENOME BIOLOGY