Regulation of the transforming growth factor   pathway by reversible ubiquitylation

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

(2011) Xiaohua Yan et al.   BIOCHEMICAL JOURNAL

The TGF-β co-receptor, CD109, promotes internalization and degradation of TGF-β receptors

(2011) Albane A. Bizet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How ubiquitination regulates the TGF-β signalling pathway: New insights and new players

(2011) Surinder M. Soond et al.   BIOESSAYS

Enhancement of TGF-  Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

(2011) V. Sharma et al.   CANCER RESEARCH

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Nuclear translocation of Skp2 facilitates its destruction in response to TGFβ signaling

(2011) Dong Hu et al.   CELL CYCLE

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

(2011) Juan F. Santibañez et al.   CLINICAL SCIENCE

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

(2011) Liu-Ya Tang et al.   EMBO JOURNAL

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells

(2011) Yongge Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity

(2011) Daizo Koinuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRB3 interacts with SMAD3 promoting tumor cell migration and invasion

(2011) F. Hua et al.   JOURNAL OF CELL SCIENCE

CD109-mediated degradation of TGF-β receptors and inhibition of TGF-β responses involve regulation of SMAD7 and Smurf2 localization and function

(2011) Albane A. Bizet et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

TSC-22 Promotes Transforming Growth Factor  -Mediated Cardiac Myofibroblast Differentiation by Antagonizing Smad7 Activity

(2011) X. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

(2011) Eleonora Agricola et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

(2011) S M Soond et al.   ONCOGENE

The therapeutic potential of deubiquitinating enzyme inhibitors

(2010) Frédéric Colland   BIOCHEMICAL SOCIETY TRANSACTIONS

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Negative control of Smad activity by ectodermin/Tif1  patterns the mammalian embryo

(2010) L. Morsut et al.   DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Reduction of transforming growth factor-β type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma

(2010) Hirotaka Fukasawa et al.   INTERNATIONAL JOURNAL OF CANCER

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation

(2010) Ichiaki Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cbl-b-/- T Cells Demonstrate In Vivo Resistance to Regulatory T Cells but a Context-Dependent Resistance to TGF- 

(2010) C. O. Adams et al.   JOURNAL OF IMMUNOLOGY

USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53

(2010) Feroz Sarkari et al.   PLoS One

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Transforming growth factor beta (TGF-β) and inflammation in cancer

(2009) Brian Bierie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells

(2009) Yoshiko Nagano et al.   JOURNAL OF BIOCHEMISTRY

Role of SARA (SMAD Anchor for Receptor Activation) in Maintenance of Epithelial Cell Phenotype

(2009) Constance E. Runyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins

(2009) Ayako Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts

(2008) Hisanori Yuzawa et al.   BONE

Transforming Growth Factor-  Suppresses the Ability of Ski to Inhibit Tumor Metastasis by Inducing Its Degradation

(2008) E. Le Scolan et al.   CANCER RESEARCH

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

TGFβ in Cancer

(2008) Joan Massagué   CELL

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

How the Smads regulate transcription

(2007) Sarah Ross et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY