How ubiquitination regulates the TGF-β signalling pathway: New insights and new players

The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1to S transition inSaccharomyces cerevisiae

(2011) Paola Coccetti et al.   CELL CYCLE

Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

(2011) Kefeng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

(2011) B. B. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

(2011) S M Soond et al.   ONCOGENE

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

Siah1 proteins enhance radiosensitivity of human breast cancer cells

(2010) Hai-Tao He et al.   BMC CANCER

Molecular characterisation of a recurrent, semi-crypticRUNX1translocation t(7;21) in myelodysplastic syndrome and acute myeloid leukaemia

(2010) Nicola Foster et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes

(2010) Jonas Fuxe et al.   CELL CYCLE

Specificity, location and function of βTrCP isoforms and their splice variants

(2010) Joyce Putters et al.   CELLULAR SIGNALLING

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation

(2010) M T Bengoechea-Alonso et al.   ONCOGENE

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner

(2009) Bing Liao et al.   CELL RESEARCH

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

(2009) Huiming Xu et al.   CELL RESEARCH

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

(2009) Thomas Mund et al.   EMBO REPORTS

Mechanisms of the epithelial–mesenchymal transition by TGF-β

(2009) Michael K Wendt et al.   Future Oncology

Identification and Characterization of Two Novel Isoforms of Pirh2 Ubiquitin Ligase That Negatively Regulate p53 Independent of RING Finger Domains

(2009) Chad A. Corcoran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

(2008) N. J. Foot et al.   BLOOD

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

The utility F-box for protein destruction

(2008) M. S. Ho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase Cβ

(2008) Kenji Tatematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK and the F-box Protein βTRCP Target STAT1 for Degradation

(2008) Surinder M. Soond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC

(2008) Matthew K. Summers et al.   MOLECULAR CELL

Activating the ubiquitin family: UBA6 challenges the field

(2008) Marcus Groettrup et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alternative UPS drug targets upstream the 26S proteasome

(2007) R HJERPE et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY