Beyond the fourth wave of genome-wide obesity association studies

Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents

(2012) Jonatan R. Ruiz   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression

(2011) Jung-Ying Tzeng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome wide association study identifies KCNMA1contributing to human obesity

(2011) Hong Jiao et al.   BMC Medical Genomics

Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women

(2011) T. Ahmad et al.   DIABETES CARE

Imputation of low-frequency variants using the HapMap3 benefits from large, diverse reference sets

(2011) Luke Jostins et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNAs in adipogenesis and as therapeutic targets for obesity

(2011) Ryan Alexander et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sample size requirements to detect gene-environment interactions in genome-wide association studies

(2011) Cassandra E. Murcray et al.   GENETIC EPIDEMIOLOGY

Comparison of statistical tests for disease association with rare variants

(2011) Saonli Basu et al.   GENETIC EPIDEMIOLOGY

Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations

(2011) R Dorajoo et al.   INTERNATIONAL JOURNAL OF OBESITY

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

(2011) Sébastien Jacquemont et al.   NATURE

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

(2011) Tuomas O Kilpeläinen et al.   NATURE GENETICS

Increased Genetic Variance of BMI with a Higher Prevalence of Obesity

(2011) Benjamin Rokholm et al.   PLoS One

Implications of Central Obesity-Related Variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on Quantitative Metabolic Traits in Adult Danes

(2011) Dorthe S. Bille et al.   PLoS One

Gene–environment interactions in human disease: nuisance or opportunity?

(2011) Carole Ober et al.   TRENDS IN GENETICS

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Life-Course Analysis of a Fat Mass and Obesity-Associated (FTO) Gene Variant and Body Mass Index in the Northern Finland Birth Cohort 1966 Using Structural Equation Modeling

(2010) M. Kaakinen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Adipokines as novel biomarkers and regulators of the metabolic syndrome

(2010) Yingfeng Deng et al.   Annals of the New York Academy of Sciences

FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

(2010) Gaifen Liu et al.   BMC Medical Genetics

Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans

(2010) Hye-Ja Lee et al.   CLINICA CHIMICA ACTA

Combined Analyses of 20 Common Obesity Susceptibility Variants

(2010) C. H. Sandholt et al.   DIABETES

FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males

(2010) Robert A Scott et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis

(2010) Ivonne Jarick et al.   HUMAN MOLECULAR GENETICS

Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA

(2010) C Holzapfel et al.   INTERNATIONAL JOURNAL OF OBESITY

Association between fat intake, physical activity and mortality depending on genetic variation in FTO

(2010) E Sonestedt et al.   INTERNATIONAL JOURNAL OF OBESITY

Implication of Genetic Variants NearNEGR1,SEC16B,TMEM18,ETV5/DGKG,GNPDA2,LIN7C/BDNF,MTCH2,BCDIN3D/FAIM2,SH2B1,FTO,MC4R, andKCTD15with Obesity and Type 2 Diabetes in 7705 Chinese

(2010) Maggie C. Y. Ng et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

(2010) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

(2010) R. G. Walters et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

(2010) Yingrui Li et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Gene–environment-wide association studies: emerging approaches

(2010) Duncan Thomas   NATURE REVIEWS GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Genetic studies of common types of obesity: a critique of the current use of phenotypes

(2010) M. J. Müller et al.   Obesity Reviews

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

(2010) Caroline L. Relton et al.   PLOS MEDICINE

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

(2009) Florianne Bauer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents’ Individual Lives Survey) Study

(2009) Eryn T Liem et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

(2009) Karani S Vimaleswaran et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity

(2009) Emily Sonestedt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genotype Imputation

(2009) Yun Li et al.   Annual Review of Genomics and Human Genetics

Case-Control Studies of Gene-Environment Interaction: Bayesian Design and Analysis

(2009) Bhramar Mukherjee et al.   BIOMETRICS

Studies of CTNNBL1 and FDFT1variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

(2009) Camilla Helene Andreasen et al.   BMC Medical Genetics

Non-replication of an association of CTNNBL1polymorphisms and obesity in a population of Central European ancestry

(2009) Carla IG Vogel et al.   BMC Medical Genetics

The common FTOvariant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924

(2009) Josefin A Jacobsson et al.   BMC Medical Genetics

Recent progress in the genetics of common obesity

(2009) Ruth J. F. Loos   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

(2009) A. Jonsson et al.   DIABETOLOGIA

The Impact of Gene-Environment Dependence and Misclassification in Genetic Association Studies Incorporating Gene-Environment Interactions

(2009) Sara Lindström et al.   HUMAN HEREDITY

Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

(2009) Frida Renström et al.   HUMAN MOLECULAR GENETICS

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure

(2009) S I I Kring et al.   INTERNATIONAL JOURNAL OF OBESITY

Inaccuracies in food and physical activity diaries of obese subjects: complementary evidence from doubly labeled water and co-twin assessments

(2009) K H Pietiläinen et al.   INTERNATIONAL JOURNAL OF OBESITY

Epigenetics: Connecting Environment and Genotype to Phenotype and Disease

(2009) S.P. Barros et al.   JOURNAL OF DENTAL RESEARCH

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

(2009) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

(2009) Stéphane Cauchi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Large, rare chromosomal deletions associated with severe early-onset obesity

(2009) Elena G. Bochukova et al.   NATURE

Origins and functional impact of copy number variation in the human genome

(2009) Donald F. Conrad et al.   NATURE

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

(2009) Mayumi Oda et al.   NUCLEIC ACIDS RESEARCH

The Common Variant in theFTOGene Did Not Modify the Effect of Lifestyle Changes on Body Weight: The Finnish Diabetes Prevention Study

(2009) Tiina J. Lappalainen et al.   Obesity

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study

(2009) Axel Haupt et al.   Obesity

Individuality and epigenetics in obesity

(2009) J. Campión et al.   Obesity Reviews

Role of microRNAs in obesity and the metabolic syndrome

(2009) H. M. Heneghan et al.   Obesity Reviews

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

(2009) Nancy L. Heard-Costa et al.   PLoS Genetics

Gene-Environment Interaction in Genome-Wide Association Studies

(2008) C. E. Murcray et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms

(2008) Ivan P. Gorlov et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity

(2008) Evadnie Rampersaud et al.   ARCHIVES OF INTERNAL MEDICINE

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?

(2008) Reinhard Stöger   BIOESSAYS

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

(2008) Camilla Helene Andreasen et al.   BMC Medical Genetics

Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes

(2008) D. P. Zobel et al.   DIABETES

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

(2008) J. T. Tan et al.   DIABETES

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

(2008) Robert Fredriksson et al.   ENDOCRINOLOGY

Gene–environment interactions for complex traits: definitions, methodological requirements and challenges

(2008) Astrid Dempfle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity

(2008) Yong-Jun Liu et al.   HUMAN MOLECULAR GENETICS

Genome-wide association studies: potential next steps on a genetic journey

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

A Mixture Model Approach in Gene–Gene and Gene–Environmental Interactions for Binary Phenotypes

(2008) Lang Li et al.   Journal of Biopharmaceutical Statistics

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Integrated detection and population-genetic analysis of SNPs and copy number variation

(2008) Steven A McCarroll et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Epidemiological Study Designs to Investigate Gene–Behavior Interactions in the Context of Human Obesity

(2008) Nicholas J. Wareham et al.   Obesity

FTO: the first gene contributing to common forms of human obesity

(2008) R. J. F. Loos et al.   Obesity Reviews