Using the molecular classification of glioblastoma to inform personalized treatment
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Title
Using the molecular classification of glioblastoma to inform personalized treatment
Authors
Keywords
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Journal
JOURNAL OF PATHOLOGY
Volume 232, Issue 2, Pages 165-177
Publisher
Wiley
Online
2013-10-12
DOI
10.1002/path.4282
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Note: Only part of the references are listed.- Glioblastomas with Oligodendroglial Component – Common Origin of the Different Histological Parts and Genetic Subclassification
- (2015) Barbara Klink et al. Analytical Cellular Pathology
- Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
- (2015) Yuchen Jiao et al. Oncotarget
- Expression of EGFRvIII in Glioblastoma: Prognostic Significance Revisited
- (2015) Nicola Montano et al. NEOPLASIA
- Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors
- (2013) Pilar Mur et al. ACTA NEUROPATHOLOGICA
- Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
- (2013) Maria Teresa Solomón et al. BMC CANCER
- Glioblastoma with Oligodendroglioma Component (GBM-O): Molecular Genetic and Clinical Characteristics
- (2013) Christina L. Appin et al. BRAIN PATHOLOGY
- Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
- (2013) Krishna P.L. Bhat et al. CANCER CELL
- Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition
- (2013) Y. Piao et al. CLINICAL CANCER RESEARCH
- Glioblastoma with oligodendroglial component represents a subgroup of glioblastoma with high prevalence of IDH1 mutation and association with younger age
- (2013) Sang Yun Ha et al. JOURNAL OF NEURO-ONCOLOGY
- Screening for EGFR Amplifications with a Novel Method and Their Significance for the Outcome of Glioblastoma Patients
- (2013) Michał Bieńkowski et al. PLoS One
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- Low rate of R132H IDH1 mutation in infratentorial and spinal cord grade II and III diffuse gliomas
- (2012) Benjamin Ellezam et al. ACTA NEUROPATHOLOGICA
- Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial
- (2012) Monika E. Hegi et al. ACTA NEUROPATHOLOGICA
- The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma
- (2012) Lee A.D. Cooper et al. AMERICAN JOURNAL OF PATHOLOGY
- Paradoxical Relationship Between the Degree of EGFR Amplification and Outcome in Glioblastomas
- (2012) Jonathan Hobbs et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Glioblastoma angiogenesis: VEGF resistance solutions and new strategies based on molecular mechanisms of tumor vessel formation
- (2012) Shingo Takano Brain Tumor Pathology
- Molecular pathogenesis of IDH mutations in gliomas
- (2012) Koichi Ichimura Brain Tumor Pathology
- Interleukins in glioblastoma pathophysiology: implications for therapy
- (2012) YT Yeung et al. BRITISH JOURNAL OF PHARMACOLOGY
- Studying a Complex Tumor
- (2012) Siyuan Zheng et al. CANCER JOURNAL
- p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells
- (2012) Yiu To Yeung et al. JOURNAL OF NEURO-ONCOLOGY
- MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors
- (2012) Marta Mellai et al. JOURNAL OF NEURO-ONCOLOGY
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
- (2012) Y. Wang et al. NEURO-ONCOLOGY
- CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009
- (2012) T. A. Dolecek et al. NEURO-ONCOLOGY
- Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
- (2012) D. Singh et al. SCIENCE
- Pseudoprogression and Pseudoresponse: Imaging Challenges in the Assessment of Posttreatment Glioma
- (2011) L.C. Hygino da Cruz et al. AMERICAN JOURNAL OF NEURORADIOLOGY
- Absence of IDH1-R132H mutation predicts rapid progression of nonenhancing diffuse glioma in older adults
- (2011) Adriana Olar et al. Annals of Diagnostic Pathology
- Genetic profile of astrocytic and oligodendroglial gliomas
- (2011) Hiroko Ohgaki et al. Brain Tumor Pathology
- Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment
- (2011) Justin D. Lathia et al. Cell Stem Cell
- A Hypermethylated Phenotype Is a Better Predictor of Survival than MGMT Methylation in Anaplastic Oligodendroglial Brain Tumors: A Report from EORTC Study 26951
- (2011) M. J. van den Bent et al. CLINICAL CANCER RESEARCH
- The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
- (2011) K. P. L. Bhat et al. GENES & DEVELOPMENT
- Molecular subclassification of diffuse gliomas: Seeing order in the chaos
- (2011) Jason T. Huse et al. GLIA
- Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
- (2011) Jörg Felsberg et al. INTERNATIONAL JOURNAL OF CANCER
- Predictive impact of MGMT promoter methylation in glioblastoma of the elderly
- (2011) Guido Reifenberger et al. INTERNATIONAL JOURNAL OF CANCER
- Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis
- (2011) Robert A. Olson et al. JOURNAL OF NEURO-ONCOLOGY
- Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
- (2011) Stephen Yip et al. JOURNAL OF PATHOLOGY
- Chemoresistance of glioblastoma cancer stem cells - much more complex than expected
- (2011) Dagmar Beier et al. Molecular Cancer
- Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib--A Phase II Trial
- (2011) M. E. Hegi et al. MOLECULAR CANCER THERAPEUTICS
- MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
- (2011) A. L. Rivera et al. NEURO-ONCOLOGY
- A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
- (2011) J. J. Raizer et al. NEURO-ONCOLOGY
- O6-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications
- (2011) A. A. Brandes et al. NEURO-ONCOLOGY
- Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice
- (2011) J. F. de Groot et al. NEURO-ONCOLOGY
- Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy
- (2011) X. Gong et al. NEUROLOGY
- EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway
- (2011) R Bonavia et al. ONCOGENE
- Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells
- (2011) Justin D. Lathia et al. PLoS One
- The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma
- (2011) Fumiharu Ohka et al. PLoS One
- Transdifferentiation of glioblastoma cells into vascular endothelial cells
- (2011) Y. Soda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing
- (2010) Jörg Felsberg et al. ACTA NEUROPATHOLOGICA
- Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas
- (2010) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- Temozolomide (Temodar)
- (2010) J.R. Wesolowski et al. AMERICAN JOURNAL OF NEURORADIOLOGY
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- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Cetuximab Insufficiently Inhibits Glioma Cell Growth Due to Persistent EGFR Downstream Signaling
- (2010) Benedikte Hasselbalch et al. CANCER INVESTIGATION
- MGMT gene promoter methylation in pediatric glioblastomas
- (2010) Arti Srivastava et al. CHILDS NERVOUS SYSTEM
- IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group
- (2010) Ian F. Pollack et al. CHILDS NERVOUS SYSTEM
- IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
- (2010) M. J. van den Bent et al. CLINICAL CANCER RESEARCH
- Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
- (2010) M.-d.-M. Inda et al. GENES & DEVELOPMENT
- Phase II Evaluation of Gefitinib in Patients With Newly Diagnosed Grade 4 Astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074
- (2010) Joon H. Uhm et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
- (2010) Barbara S. Paugh et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme
- (2010) Albert Lai et al. JOURNAL OF CLINICAL ONCOLOGY
- Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma
- (2010) Vivek Sharma et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers
- (2010) Michael Jansen et al. LANCET NEUROLOGY
- Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
- (2010) Lucia Ricci-Vitiani et al. NATURE
- Glioblastoma stem-like cells give rise to tumour endothelium
- (2010) Rong Wang et al. NATURE
- Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors
- (2010) B. J. Scott et al. NEURO-ONCOLOGY
- Bevacizumab in recurrent high-grade pediatric gliomas
- (2010) A. Narayana et al. NEURO-ONCOLOGY
- All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2
- (2010) M. Labussiere et al. NEUROLOGY
- O6-Methylguanine DNA Methyltransferase Gene Promoter Methylation Status in Gliomas and Its Correlation With Other Molecular Alterations: First Indian Report With Review of Challenges for Use in Customized Treatment
- (2010) Prerana Jha et al. NEUROSURGERY
- The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas
- (2010) Lee A. D. Cooper et al. PLoS One
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
- (2009) Takuya Watanabe et al. AMERICAN JOURNAL OF PATHOLOGY
- Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model
- (2009) Sheila Alcantara Llaguno et al. CANCER CELL
- Allelic status of 1p and 19q in oligodendrogliomas and glioblastomas: multiplex ligation-dependent probe amplification versus loss of heterozygosity
- (2009) Carmen Franco-Hernández et al. CANCER GENETICS AND CYTOGENETICS
- Analysis ofIDH1andIDH2mutations in Japanese glioma patients
- (2009) Yukihiko Sonoda et al. CANCER SCIENCE
- IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
- (2009) S. Nobusawa et al. CLINICAL CANCER RESEARCH
- Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network
- (2009) Michael Weller et al. JOURNAL OF CLINICAL ONCOLOGY
- Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
- (2009) Henry S. Friedman et al. JOURNAL OF CLINICAL ONCOLOGY
- Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas
- (2009) Marc Sanson et al. JOURNAL OF CLINICAL ONCOLOGY
- Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034
- (2009) Martin J. van den Bent et al. JOURNAL OF CLINICAL ONCOLOGY
- NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide
- (2009) Wolfgang Wick et al. JOURNAL OF CLINICAL ONCOLOGY
- Diagnostic Use ofIDH1/2Mutation Analysis in Routine Clinical Testing of Formalin-Fixed, Paraffin-Embedded Glioma Tissues
- (2009) Craig Horbinski et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
- (2009) Roger Stupp et al. LANCET ONCOLOGY
- The transcriptional network for mesenchymal transformation of brain tumours
- (2009) Maria Stella Carro et al. NATURE
- Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
- (2009) Bin-Bing S. Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
- (2009) Michael Weller et al. Nature Reviews Neurology
- IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
- (2009) Koichi Ichimura et al. NEURO-ONCOLOGY
- Primary glioblastomas with and without EGFR amplification: Relationship to genetic alterations and clinicopathological features
- (2009) Rafael Benito et al. NEUROPATHOLOGY
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
- Gliomas With 1p/19q Codeletion:a.k.a. Oligodendroglioma
- (2008) Gregory Cairncross et al. CANCER JOURNAL
- Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme
- (2008) R. Pallini et al. CLINICAL CANCER RESEARCH
- Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells
- (2008) Akio Soeda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MGMTPromoter Methylation Status Can Predict the Incidence and Outcome of Pseudoprogression After Concomitant Radiochemotherapy in Newly Diagnosed Glioblastoma Patients
- (2008) Alba A. Brandes et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177
- (2008) Paul D. Brown et al. JOURNAL OF CLINICAL ONCOLOGY
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- Cancer-related inflammation
- (2008) Alberto Mantovani et al. NATURE
- Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
- (2008) A. D. Norden et al. NEUROLOGY
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
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