Innate and Adaptive Immunity in Calcific Aortic Valve Disease

Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis: A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort

(2014) B. J. Arsenault et al.   Circulation-Cardiovascular Genetics

Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway

(2014) Rui Song et al.   INFLAMMATION RESEARCH

P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease

(2014) Diala El Husseini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-κB Activation

(2013) Qingchun Zeng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease

(2013) Huige Li et al.   CURRENT OPINION IN PHARMACOLOGY

Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling

(2013) Ablajan Mahmut et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis

(2013) Romain Capoulade et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Lp-PLA2 is associated with structural valve degeneration of bioprostheses

(2013) Ablajan Mahmut et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand

(2013) Antonella Galeone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism

(2013) Rihab Bouchareb et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ox-LDL induces PiT-1 expression in human aortic valve interstitial cells

(2013) Nicole A. Nadlonek et al.   JOURNAL OF SURGICAL RESEARCH

New Therapeutic Targets for Calcific Aortic Valve Stenosis

(2013) Ming-Yow Hung et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated Expression of Lipoprotein-Associated Phospholipase A2 in Calcific Aortic Valve Disease

(2013) Ablajan Mahmut et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

(2013) Pia R. Kamstrup et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

(2013) Sergio Bertazzo et al.   NATURE MATERIALS

Genetic Associations with Valvular Calcification and Aortic Stenosis

(2013) George Thanassoulis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin Receptor Blockers Are Associated with Reduced Fibrosis and Interleukin-6 Expression in Calcific Aortic Valve Disease

(2013) Nancy Côté et al.   PATHOBIOLOGY

High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

(2013) Diala El Husseini et al.   PLoS One

Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

(2013) Robert M. Weiss et al.   PLoS One

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

(2012) Rui Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells

(2012) Gretchen J. Mahler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis

(2012) Emanuela Branchetti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice

(2012) Tomohiro Fujisaka et al.   ATHEROSCLEROSIS

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

(2012) Narin Osman et al.   CARDIOVASCULAR PATHOLOGY

Cross-Talk Between the Toll-Like Receptor 4 and Notch1 Pathways Augments the Inflammatory Response in the Interstitial Cells of Stenotic Human Aortic Valves

(2012) Q. Zeng et al.   CIRCULATION

Pharmacology of ectonucleotidases: Relevance for the treatment of cardiovascular disorders

(2012) Patrick Mathieu   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats

(2012) Nancy Côté et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IKK biology

(2012) Fei Liu et al.   IMMUNOLOGICAL REVIEWS

Mast Cells in Human Stenotic Aortic Valves Are Associated with the Severity of Stenosis

(2012) E. Wypasek et al.   INFLAMMATION

Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease

(2012) Nancy Coté et al.   INFLAMMATION

Site-specific Phosphorylation of the p65 Protein Subunit Mediates Selective Gene Expression by Differential NF-κB and RNA Polymerase II Promoter Recruitment

(2012) Karin Hochrainer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-HT2B antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation

(2012) Joshua D. Hutcheson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ATP acts as a survival signal and prevents the mineralization of aortic valve

(2012) Nancy Côté et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts

(2011) Edit Nagy et al.   CIRCULATION

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review

(2011) Ida Perrotta et al.   HISTOPATHOLOGY

Treatment With Methotrexate Inhibits Atherogenesis in Cholesterol-Fed Rabbits

(2011) Adriana Bulgarelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Circulating Activated and Effector Memory T Cells Are Associated with Calcification and Clonal Expansions in Bicuspid and Tricuspid Valves of Calcific Aortic Stenosis

(2011) R. Winchester et al.   JOURNAL OF IMMUNOLOGY

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

(2010) Habib Derbali et al.   AMERICAN JOURNAL OF PATHOLOGY

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

(2010) Kikuo Isoda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

(2010) Jan-Hung Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

(2010) D. Poeckel et al.   CARDIOVASCULAR RESEARCH

The nuclear factor- B-interleukin-6 signalling pathway mediating vascular inflammation

(2010) A. R. Brasier   CARDIOVASCULAR RESEARCH

Obesity, Inflammation, and Cardiovascular Risk

(2010) P Mathieu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gene-Specific Repression of Proinflammatory Cytokines in Stimulated Human Macrophages by Nuclear I B 

(2010) C. C. Ghosh et al.   JOURNAL OF IMMUNOLOGY

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tumor necrosis factor-α increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction

(2009) Hye-Lim Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Visceral Obesity

(2009) Patrick Mathieu et al.   HYPERTENSION

Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis

(2009) Nancy Côté et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Notch1 represses osteogenic pathways in aortic valve cells

(2009) Vishal Nigam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)

(2009) PAUL M. RIDKER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vascular calcification and bone disease: the calcification paradox

(2009) Veerle Persy et al.   TRENDS IN MOLECULAR MEDICINE

Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

(2008) Jordan D. Miller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association Between Plasma LDL Particle Size, Valvular Accumulation of Oxidized LDL, and Inflammation in Patients With Aortic Stenosis

(2007) Dania Mohty et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis

(2007) C Cote et al.   HEART