Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions

The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE)

(2018) Christopher Bolton et al.   AGEING RESEARCH REVIEWS

Repetitive Transcranial Magnetic Stimulation, Cognition, and Multiple Sclerosis: An Overview

(2018) Grigorios Nasios et al.   BEHAVIOURAL NEUROLOGY

Cognitive reserve, cognition, and regional brain damage in MS: A 2 -year longitudinal study

(2018) Maria Assunta Rocca et al.   Multiple Sclerosis Journal

Progressive Forms of Multiple Sclerosis

(2018) Burcu Zeydan et al.   NEUROLOGIC CLINICS

Cognitive reserve, cognition, and regional brain damage in MS: A 2 -year longitudinal study

(2018) Maria Assunta Rocca et al.   Multiple Sclerosis Journal

Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis

(2017) Rosa E. Boeschoten et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Exercise in patients with multiple sclerosis

(2017) Robert W Motl et al.   LANCET NEUROLOGY

Interferon-γ causes mood abnormalities by altering cannabinoid CB1 receptor function in the mouse striatum

(2017) Georgia Mandolesi et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis

(2017) Silvia Rossi et al.   NEUROLOGY

The effects of aging in the hippocampus and cognitive decline

(2017) Luis E.B. Bettio et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Functional Components of Cognitive Impairment in Multiple Sclerosis: A Cross-Sectional Investigation

(2017) Jordi A. Matias-Guiu et al.   Frontiers in Neurology

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation

(2016) Stephanie M Matt et al.   CURRENT OPINION IN PHARMACOLOGY

Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis

(2016) Antonietta Gentile et al.   Journal of Neuroinflammation

miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation

(2016) Georgia Mandolesi et al.   JOURNAL OF NEUROSCIENCE

Synergistic Effects of Reserve and Adaptive Personality in Multiple Sclerosis

(2016) Shumita Roy et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Differential effects of aging on motor and cognitive functioning in multiple sclerosis

(2016) Shumita Roy et al.   Multiple Sclerosis Journal

Aging and multiple sclerosis

(2016) Shaik Ahmed Sanai et al.   Multiple Sclerosis Journal

Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes

(2016) Luis Ruano et al.   Multiple Sclerosis Journal

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

(2016) Tomas Olsson et al.   Nature Reviews Neurology

Systematically developed pilot randomized controlled trial of exercise and cognition in persons with multiple sclerosis

(2016) Brian M. Sandroff et al.   NEUROCASE

Systematic, Evidence-Based Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple Sclerosis

(2016) Brian M. Sandroff et al.   NEUROPSYCHOLOGY REVIEW

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

Differential effects of aging on motor and cognitive functioning in multiple sclerosis

(2016) Shumita Roy et al.   Multiple Sclerosis Journal

Aging and multiple sclerosis

(2016) Shaik Ahmed Sanai et al.   Multiple Sclerosis Journal

Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes

(2016) Luis Ruano et al.   Multiple Sclerosis Journal

Synaptic plasticity and experimental autoimmune encephalomyelitis: implications for multiple sclerosis

(2015) Massimiliano Di Filippo et al.   BRAIN RESEARCH

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

(2015) Marina A Lynch   BRAIN RESEARCH

Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing−remitting, secondary progressive and primary progressive multiple sclerosis

(2015) V. Planche et al.   EUROPEAN JOURNAL OF NEUROLOGY

The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset

(2015) Helen Tedeholm et al.   JOURNAL OF NEUROLOGY

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

(2015) Maria A Rocca et al.   LANCET NEUROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Treatment of progressive multiple sclerosis: what works, what does not, and what is needed

(2015) Anthony Feinstein et al.   LANCET NEUROLOGY

Longitudinal fMRI studies: Exploring brain plasticity and repair in MS

(2015) Christian Enzinger et al.   Multiple Sclerosis Journal

Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis

(2015) Georgia Mandolesi et al.   Nature Reviews Neurology

Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis

(2015) Martina Novotna et al.   NEUROLOGY

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

HSC Aging and Senescent Immune Remodeling

(2015) Michael D. Denkinger et al.   TRENDS IN IMMUNOLOGY

Impact of age-related neuroglial cell responses on hippocampal deterioration

(2015) Joseph O. Ojo et al.   Frontiers in Aging Neuroscience

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Longitudinal fMRI studies: Exploring brain plasticity and repair in MS

(2015) Christian Enzinger et al.   Multiple Sclerosis Journal

Improved Physical Fitness Correlates With Improved Cognition in Multiple Sclerosis

(2014) Meghan Beier et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Risk of relapse phenotype recurrence in multiple sclerosis

(2014) Tomas Kalincik et al.   Multiple Sclerosis Journal

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

(2014) Manuel A. Friese et al.   Nature Reviews Neurology

Plasticity of the motor system in multiple sclerosis

(2014) D. Zeller et al.   NEUROSCIENCE

Disability in multiple sclerosis: When synaptic long-term potentiation fails

(2014) Sagit Weiss et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Higher Education Moderates the Effect of T2 Lesion Load and Third Ventricle Width on Cognition in Multiple Sclerosis

(2014) Daniela Pinter et al.   PLoS One

Associations between onset age and disability in multiple sclerosis patients studied using MSSS and a progression model

(2014) Sudarshan Ramachandran et al.   Multiple Sclerosis and Related Disorders

Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosis

(2013) Brian M. Sandroff et al.   JOURNAL OF NEUROLOGY

Synaptic Plasticity and PDGF Signaling Defects Underlie Clinical Progression in Multiple Sclerosis

(2013) F. Mori et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1  Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis

(2013) G. Mandolesi et al.   JOURNAL OF NEUROSCIENCE

Cortical plasticity predicts recovery from relapse in multiple sclerosis

(2013) Francesco Mori et al.   Multiple Sclerosis Journal

Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration

(2013) Silvia Rossi et al.   Multiple Sclerosis Journal

Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial

(2013) S Briken et al.   Multiple Sclerosis Journal

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Cognitive impairment differs between primary progressive and relapsing-remitting MS

(2013) A. Ruet et al.   NEUROLOGY

Cognitive reserve and cortical atrophy in multiple sclerosis: A longitudinal study

(2013) M. P. Amato et al.   NEUROLOGY

Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it

(2013) J. F. Sumowski et al.   NEUROLOGY

Interleukin-1β Promotes Long-Term Potentiation in Patients with Multiple Sclerosis

(2013) Francesco Mori et al.   NEUROMOLECULAR MEDICINE

Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis

(2013) Robert Nisticò et al.   PLoS One

Opposite Roles of NMDA Receptors in Relapsing and Primary Progressive Multiple Sclerosis

(2013) Silvia Rossi et al.   PLoS One

Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis

(2012) G Grasselli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview

(2012) Vincenzo Pizza et al.   CNS & Neurological Disorders-Drug Targets

TNF-α-mediated anxiety in a mouse model of multiple sclerosis

(2012) Nabila Haji et al.   EXPERIMENTAL NEUROLOGY

The genetics of multiple sclerosis: an up-to-date review

(2012) Pierre-Antoine Gourraud et al.   IMMUNOLOGICAL REVIEWS

The benefits of exercise training in multiple sclerosis

(2012) Robert W. Motl et al.   Nature Reviews Neurology

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Neuroplasticity and functional recovery in multiple sclerosis

(2012) Valentina Tomassini et al.   Nature Reviews Neurology

GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis

(2012) Georgia Mandolesi et al.   NEUROBIOLOGY OF DISEASE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Occupational Attainment as a Marker of Cognitive Reserve in Multiple Sclerosis

(2012) Omar Ghaffar et al.   PLoS One

Early Relapses, Onset of Progression, and Late Outcome in Multiple Sclerosis

(2012) Antonio Scalfari et al.   JAMA Neurology

Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis

(2011) Silvia Rossi et al.   ANNALS OF NEUROLOGY

Characterizing Brain Cortical Plasticity and Network Dynamics Across the Age-Span in Health and Disease with TMS-EEG and TMS-fMRI

(2011) Alvaro Pascual-Leone et al.   BRAIN TOPOGRAPHY

Depression and anxiety in a Portuguese MS population: Associations with physical disability and severity of disease

(2011) Ana Martins da Silva et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Age at onset as a determinant of presenting phenotype and initial relapse recovery in multiple sclerosis

(2011) M Cossburn et al.   Multiple Sclerosis Journal

Depression, disability and cognitive impairment in multiple sclerosis: a cross sectional Italian study

(2011) Flavia Mattioli et al.   NEUROLOGICAL SCIENCES

Age and disability accumulation in multiple sclerosis

(2011) A. Scalfari et al.   NEUROLOGY

Changes in Cortical Plasticity Across the Lifespan

(2011) Catarina Freitas et al.   Frontiers in Aging Neuroscience

Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?

(2011) Ulrik Dalgas et al.   Therapeutic Advances in Neurological Disorders

The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability

(2010) Antonio Scalfari et al.   BRAIN

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis

(2010) Silvia Rossi et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokines and neuronal channels: A molecular basis for age-related decline of neuronal function?

(2010) Barbara Viviani et al.   EXPERIMENTAL GERONTOLOGY

Cognitive reserve moderates decline in information processing speed in multiple sclerosis patients

(2010) RALPH H.B. BENEDICT et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

The limits of functional reorganization in multiple sclerosis

(2010) M. M. Schoonheim et al.   NEUROLOGY

Rapid-onset central motor plasticity in multiple sclerosis

(2010) D. Zeller et al.   NEUROLOGY

Preserved brain adaptive properties in patients with benign multiple sclerosis

(2010) M. A. Rocca et al.   NEUROLOGY

Default-mode network dysfunction and cognitive impairment in progressive MS

(2010) M. A. Rocca et al.   NEUROLOGY

Cognitive and Cortical Plasticity Deficits Correlate with Altered Amyloid-β CSF Levels in Multiple Sclerosis

(2010) Francesco Mori et al.   NEUROPSYCHOPHARMACOLOGY

Neuroplasticity predicts outcome of optic neuritis independent of tissue damage

(2009) Thomas M. Jenkins et al.   ANNALS OF NEUROLOGY

Cognitive Aging in Patients with Multiple Sclerosis: A Cross-Sectional Analysis of Speeded Processing

(2009) A. M. Bodling et al.   ARCHIVES OF CLINICAL NEUROPSYCHOLOGY

Cognitive reserve protects against cognitive dysfunction in multiple sclerosis

(2009) James F. Sumowski et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection and neuroregeneration in multiple sclerosis

(2009) Martin Stangel   JOURNAL OF NEUROLOGY

Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis

(2009) D. Centonze et al.   JOURNAL OF NEUROSCIENCE

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Consensus: Motor cortex plasticity protocols

(2008) Ulf Ziemann et al.   Brain Stimulation

Depression and anxiety amongst multiple sclerosis patients

(2008) A. G. Beiske et al.   EUROPEAN JOURNAL OF NEUROLOGY

Validation study of prevalence and correlates of depressive symptomatology in multiple sclerosis

(2008) Alyssa M. Bamer et al.   GENERAL HOSPITAL PSYCHIATRY

Clinical characteristics of patients with late-onset multiple sclerosis

(2008) B. Kis et al.   JOURNAL OF NEUROLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Functional MR Imaging in Multiple Sclerosis

(2008) Massimo Filippi et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation

(2008) J. Florian M. Müller-Dahlhaus et al.   EXPERIMENTAL BRAIN RESEARCH

Cognitive impairment in different MS subtypes and clinically isolated syndromes

(2007) Constantin Potagas et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES