The IL-23/IL-17 pathway in inflammatory bowel disease

An Evidence-Based Systematic Review on Medical Therapies for Inflammatory Bowel Disease

(2011) Nicholas J Talley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

(2011) Johannes Stallhofer et al.   DIGESTION

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

(2011) Paola Di Meglio et al.   PLoS One

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

(2011) Svetlana Pidasheva et al.   PLoS One

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

(2011) R. Sarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Activity, ANCA and IL23R Genotype Status Determine Early Response to Infliximab in Patients With Ulcerative Colitis

(2010) Matthias Jürgens et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The IL-17 pathway as a major therapeutic target in autoimmune diseases

(2010) Yan Hu et al.   Annals of the New York Academy of Sciences

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Interleukin-17 and its expanding biological functions

(2010) Sheng Xu et al.   Cellular & Molecular Immunology

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

(2010) M. NIESSNER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumor Necrosis Factor-α Monoclonal Antibodies in the Treatment of Inflammatory Bowel Disease: Clinical Practice Pharmacology

(2010) Thomas W. Lee et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2

(2010) Natasha K. Crellin et al.   IMMUNITY

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

(2010) Gregory F. Sonnenberg et al.   IMMUNITY

Bacteria, mucosal-associated invariant T cells and MR1

(2010) Wei-Jen Chua et al.   IMMUNOLOGY AND CELL BIOLOGY

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

(2010) Naoko Satoh-Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

Cytokine Requirements for the Differentiation and Expansion of IL-17A- and IL-22-Producing Human V 2V 2 T Cells

(2010) K. J. Ness-Schwickerath et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease

(2009) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Relationship of C-Reactive Protein With Clinical Response After Therapy With Ustekinumab in Crohn's Disease

(2009) Gary P Toedter et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis

(2009) Yoshinaga Ito et al.   ARTHRITIS AND RHEUMATISM

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury

(2009) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR + Lymphoid Tissue Inducer Cells

(2009) S. Schmutz et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population

(2009) Bin Chen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Development of Secondary Lymphoid Organs

(2008) Troy D. Randall et al.   Annual Review of Immunology

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation

(2008) John W. Northfield et al.   HEPATOLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

(2008) Veera Hölttä et al.   INFLAMMATORY BOWEL DISEASES

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

(2008) M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES