TCF7L2 splice variants have distinct effects on β-cell turnover and function

Genotype and Tissue-Specific Effects on Alternative Splicing of the Transcription Factor 7-Like 2 Gene in Humans

(2010) Ashis K. Mondal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

(2010) Andreas Weise et al.   NUCLEIC ACIDS RESEARCH

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

(2009) K. Pilgaard et al.   DIABETOLOGIA

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

(2009) P. Osmark et al.   DIABETOLOGIA

Tissue-specific alternative splicing of TCF7L2

(2009) Ludmila Prokunina-Olsson et al.   HUMAN MOLECULAR GENETICS

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Nuclear-Cytoplasmic Shuttling of Menin Regulates Nuclear Translocation of  -Catenin

(2009) Y. Cao et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes

(2009) Ludmila Prokunina-Olsson et al.   PLoS One

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells

(2008) Merewyn K. Loder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update

(2008) Valeriya Lyssenko   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function

(2008) John RB Perry et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

(2008) Z. Liu et al.   DIABETOLOGIA