Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Biochemistry & Molecular Biology
Jing-Xian Xu, Ke Fang, Xin-Ran Gao, Sen Liu, Jin-Fang Ge
Summary: Resveratrol has been shown to alleviate neurotoxicity induced by oleic acid, decrease the overexpression of SREBP1 and PPAR alpha, and improve insulin resistance.
NEUROCHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Johanna Grinat, Frauke Kosel, Neha Goveas, Andrea Kranz, Dimitra Alexopoulou, Klaus Rajewsky, Michael Sigal, A. Francis Stewart, Julian Heuberger
Summary: This study reveals the importance of histone methyltransferase Mll1 in the control of lineage specification of intestinal secretory Paneth and goblet cells. Mll1 prevents intestinal progenitor cells from differentiation but also plays a role in the differentiation of secretory cells. Furthermore, loss of Mll1 leads to aberrant activation of Mapk signaling, which affects intestinal cell differentiation.
LIFE SCIENCE ALLIANCE
(2022)
Article
Oncology
Yajun Luo, Siqi Huang, Jinlai Wei, He Zhou, Wuyi Wang, Jianguo Yang, Qican Deng, Hao Wang, Zhongxue Fu
Summary: This study reveals that the high expression of LINC01606 is closely associated with poor prognosis in colon cancer. LINC01606 promotes tumor cell proliferation and invasion by regulating miR-423-5p and the Wnt/β-catenin pathway, while inhibiting ferroptosis. It is a potential therapeutic target for colon cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Yu-Chih Lin, Alexander Haas, Anja Bufe, Sabnam Parbin, Magdalena Hennecke, Oksana Voloshanenko, Julia Gross, Michael Boutros, Sergio P. Acebron, Holger Bastians
Summary: Wnt signaling plays a crucial role in proper mitosis and chromosome stability in human somatic cells, with Wnt10b and GSK3β identified as essential components of this cellular machinery.
LIFE SCIENCE ALLIANCE
(2021)
Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jens-Jacob L. Lauterlein, Pernille Hermann, Thomas Konrad, Peter Wolf, Peter Nilsson, Rafael Gabriel Sanchez, Ele Ferrannini, Beverley Balkau, Kurt Hojlund, Morten Frost
Summary: Overall, serum sclerostin was not associated with prediabetes, insulin sensitivity, or insulin secretion in healthy men. However, there were weak inverse relationships between serum sclerostin and insulin sensitivity in men without prediabetes at follow-up, and with beta cell glucose sensitivity in men with prediabetes. Further research is needed to clarify the ability of insulin to reduce sclerostin and its potential role in promoting bone formation.
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Alexandra Aliluev, Sophie Tritschler, Michael Sterr, Lena Oppenlaender, Julia Hinterdobler, Tobias Greisle, Martin Irmler, Johannes Beckers, Na Sun, Axel Walch, Kerstin Stemmer, Alida Kindt, Jan Krumsiek, Matthias H. Tschop, Malte D. Luecken, Fabian J. Theis, Heiko Lickert, Anika Boettcher
Summary: This study reveals that an obesogenic diet induces hyperproliferation of intestinal stem cells and progenitors in mice, leading to changes in intestinal cell identities and mucosal changes associated with obesity. The molecular mechanisms linking increased fatty acid synthesis, Ppar signaling, and the Insr-Igf1r-Akt pathway to these changes are described, shedding light on the pathogenesis of metabolic syndrome.
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
