Article
Chemistry, Multidisciplinary
Bing-bing Zhang, Xiao-jie Chen, Xu-dong Fan, Jing-jing Zhu, Ying-hui Wei, Hang-sheng Zheng, Hong-yue Zheng, Bin-hui Wang, Ji-gang Piao, Fan-zhu Li
Summary: Nanomedicine using dual-pH-responsive nanoparticles coated with polyacrylic acid and pH-sensitive lipid for synergistic delivery of arsenic trioxide and paclitaxel showed significant synergistic effects in cancer treatment. The nanoparticles exhibited enhanced drug release in cells and deeper penetration into tumors through a tumor priming effect.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Ruma Rani, Parth Malik, Sunena Dhania, Tapan Kumar Mukherjee
Summary: Breast cancer ranks second in cancer-related global female deaths. Late diagnosis and drug resistance limit the effectiveness of chemotherapeutic drugs, leading to relapse and metastasis. Core-shell mesoporous silica nanoparticles (MSNPs) have emerged as potential drug carriers for breast cancer treatment due to their high surface area, drug loading capacity, and stealth drug delivery capabilities. This article discusses the preparation methods, drug delivery mechanisms, and emerging utility of MSNPs in breast cancer treatment.
Article
Chemistry, Applied
Iman Akbarzadeh, Anita Saremi Poor, Mohsen Khodarahmi, Mohammadreza Abdihaji, Ali Moammeri, Samaneh Jafari, Zahra Salehi Moghaddam, Mahdi Seif, Maryam Moghtaderi, Zahra Asghari Lalami, Maryam Heydari, Hossein Adelnia, Bahareh Farasati Far
Summary: In this study, the in-silico properties of Gingerol and Letrozole, two potential anti-cancer drugs, were investigated and their ADME drawbacks were predicted. To address these drawbacks, mesoporous silica nanoparticles (MZNGs) were prepared and functionalized, and used as carriers for loading and delivery of the drugs to breast cancer cells. The results showed that the loaded MZNGs effectively inhibited cancer cell proliferation, migration, and invasion through the regulation of gene expression levels. Overall, the Let/Gin-loaded MZNGs demonstrated a suitable and efficient nanosystem for co-delivery of Letrozole and Gingerol with a synergistic effect, offering promise for the treatment of breast cancer and other cancers.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Medicine, Research & Experimental
Akanksha Behl, Parul Sarwalia, Sushil Kumar, Chittaranjan Behera, Mubashir Javed Mintoo, Tirtha Kumar Datta, Prem N. Gupta, Anil K. Chhillar
Summary: The synergistic potential of MUC1 inhibitors and Gemcitabine-loaded nanoparticles was discussed in this study, aiming to enhance the therapeutic efficacy. Gemcitabine and MUC1 inhibitors were loaded into polymeric nanoparticles using the double emulsion solvent evaporation method. The results showed that the twin-loaded nanoparticles exhibited better anticancer effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Wei Wang, Fengmin Zhong, Dun Wang, Yuqi Zhao, Dongdong Peng, Shuang Li, Qian Ning, Shengsong Tang, Cui-Yun Yu, Hua Wei
Summary: The construction of dual gatekeepers-functionalized mesoporous organic silica nanoparticles with both physical and chemical mechanisms provides a solution for the extracellular stability and intracellular therapeutic efficiency. This study demonstrates the successful use of diselenium-bridged MONs decorated with a dual gatekeeper, azobenzene/polydopamine, for modulated drug delivery properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Razieh Heidari, Vahideh Assadollahi, Pegah Khosravian, Seyed Abbas Mirzaei, Fatemeh Elahian
Summary: The use of nucleic acid to control gene expression is crucial in cancer research, and delivering nucleic acids using nanoparticles has emerged as a safe and efficient system for gene transfer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Electrical & Electronic
Khanittha Ponsanti, Benchamaporn Tangnorawich, Nipaporn Ngernyuang, Chiravoot Pechyen
Summary: This article reports the synthesis of mesoporous silica nanoparticles-silver nanoparticles (MSNs-AgNPs) for breast cancer cell detection. The functionalization of MSNs-AgNPs with anti-HER2 antibodies resulted in a colorimetric assay for breast cancer cell detection.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Wenhua Zhan, Hanrui Li, Yingying Guo, Lu Yang, Liaojun Pang, Chaolin Zhang
Summary: Chemotherapy is limited by drug toxicity and side effects in treating breast cancer, but the combination of photothermal therapy with chemotherapy shows promise. A biodegradable mesoporous silica nanoparticle (bMSN NPs) system for loading doxorubicin (DOX) and IR780 has shown excellent therapeutic effects on breast cancer cells in vitro and in vivo.
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Pharmacology & Pharmacy
Zahra Mohebian, Mirzaagha Babazadeh, Nosratollah Zarghami, Hanieh Mousazadeh
Summary: In this study, Curcumin was successfully incorporated into mesoporous silica nanoparticles and then embedded into a polymer via a blending electrospinning process to create a nanofiber-mediated drug release system. The resulting composite nanofibers showed sustained drug release properties and demonstrated high cytotoxicity and low migration in treating breast cancer cells, suggesting a promising potential for post-surgical breast cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Thashini Moodley, Moganavelli Singh
Summary: Cancer remains a devastating non-communicable disease with increasing incidence and mortality rates. The development of novel therapeutic strategies using multimodal nanotechnology is critical in enhancing therapeutic outcomes and overcoming resistance. Mesoporous silica nanoparticles have shown promising potential in cancer therapy with their stimuli-responsive controlled release functions and increased bioavailability.
Article
Engineering, Biomedical
Shiwei Niu, Xuejing Zhang, Gareth R. Williams, Jianrong Wu, Feng Gao, Zi Fu, Xia Chen, Sheng Lu, Li-Min Zhu
Summary: The study encapsulated the anticancer drug doxorubicin (DOX) in chitosan (CS)-modified hollow mesoporous silica nanoparticles (HMSNs), with CuS nanodots generating energy under near infrared laser (NIR) irradiation to accelerate drug release, achieving targeted drug delivery to the tumor microenvironment while demonstrating excellent photothermal therapy and dual-imaging properties.
ACTA BIOMATERIALIA
(2021)
Review
Medicine, Research & Experimental
Saurabh Shah, Paras Famta, Deepkumar Bagasariya, Kondasingh Charankumar, Anupama Sikder, Rama Kashikar, Arun K. Kotha, Mahavir Bhupal Chougule, Dharmendra Kumar Khatri, Amit Asthana, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSN) as delivery vehicles in cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters affecting MSN synthesis, drug loading characteristics, and targeting cancer cells specifically are explained. The applications and potential of MSN in nanotheranostics and imaging are illustrated. The review also discusses the hurdles encountered during the translation process and potential solutions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Monika Sharma, Shweta Sharma, Vikas Sharma, Komal Sharma, Santosh Kumar Yadav, Pankaj Dwivedi, Satish Agrawal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Jagdamba Prasad Maikhuri, Gopal Gupta, Prabhat Ranjan Mishra, Ajay Kumar Singh Rawat
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Nanoscience & Nanotechnology
Satish Agrawal, Monika Dwivedi, Hafsa Ahmad, Sangappa Basanna Chadchan, Abhishek Arya, Roshan Sikandar, Shweta Kaushik, Kalyan Mitra, Rajesh Kumar, Anil Kumar Dwivedi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Pharmacology & Pharmacy
Poonam Parashar, Meena Rathor, Monika Dwivedi, Shubhini A. Saraf
Article
Biochemistry & Molecular Biology
Poonam Parashar, Preeti Rana, Monika Dwivedi, Shubhini A. Saraf
JOURNAL OF LIPOSOME RESEARCH
(2019)
Article
Chemistry, Analytical
Jyotsana Dwivedi, Abhishek Gupta, Shikhar Verma, Monika Dwivedi, Sarvesh Paliwal, Ajay Kumar Singh Rawat
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
(2018)
Article
Materials Science, Biomaterials
Pankaj Dwivedi, Shuya Han, Farhana Mangrio, Rong Fan, Monika Dwivedi, Zhigiang Zhu, Fangsheng Huang, Qiang Wu, Renuka Khatik, David E. Cohn, Ting Si, Shuiying Hu, Alex Sparreboom, Ronald X. Xu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Shuya Han, Pankaj Dwivedi, Farhana Akbar Mangrio, Monika Dwivedi, Renuka Khatik, David E. Cohn, Ting Si, Ronald X. Xu
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Xiaoxiao Chen, Wenqiang Du, Ze Cai, Shengyun Ji, Monika Dwivedi, Jianfeng Chen, Gang Zhao, Jiaru Chu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Correction
Materials Science, Biomaterials
Pankaj Dwivedi, Shuya Han, Farhana Mangrio, Rong Fan, Monika Dwivedi, Zhiqiang Zhu, Fangsheng Huang, Qiang Wu, Renuka Khatik, David E. Cohn, Ting Si, Shuiying Hu, Alex Sparreboom, Ronald X. Xu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Pankaj Dwivedi, Sonia Kiran, Shuya Han, Monika Dwivedi, Renuka Khatik, Rong Fan, Farhana Akbar Mangrio, Kun Du, Zhiqiang Zhu, Chaoyu Yang, Fangsheng Huang, Aslam Ejaz, Renzhi Han, Ting Si, Ronald Xu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Pharmacology & Pharmacy
Poonam Parashar, Surabhi Pal, Monika Dwivedi, Shubhini A. Saraf
Article
Chemistry, Organic
Jyotsana Dwivedi, Monika Dwivedi, Swati Gupta, Vishwajeet Jadaun, Babita Yadav, Poonam Parashar, Priyanka Dhar, Pankaj Dwivedi, Hafsa Ahmed, Priyam Singh, Anirban Pal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Ajay Kumar Singh Rawat
Summary: Diabetes mellitus is a metabolic threat leading to various complications, and the synthesis of plant molecular hybrids from potent biomarkers has shown potential in combating diabetes, hyperlipidemia, and oxidative stress, with PMH4 standing out as particularly effective.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Sonia Kiran, Pankaj Dwivedi, Renuka Khatik, Sadaf Hameed, Monika Dwivedi, Fangsheng Huang, Ronald X. Xu
CHEMICAL COMMUNICATIONS
(2020)
Article
Materials Science, Biomaterials
Venkatesh Teja Banala, Sandeep Urandur, Shweta Sharma, Madhu Sharma, Ravi P. Shukla, Disha Marwaha, Shalini Gautam, Monika Dwivedi, Prabhat Ranjan Mishra
BIOMATERIALS SCIENCE
(2019)