Impact of the hypoxic phenotype on the uptake and efflux of nanoparticles by human breast cancer cells

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research

(2017) Trenton L. Place et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular signatures in breast cancer

(2017) Samir Lal et al.   METHODS

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

(2017) Miles A. Miller et al.   Science Translational Medicine

Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity

(2017) Helena C. Christianson et al.   Oncotarget

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells

(2016) Xuanchun Wang et al.   DIABETES

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

(2016) Yu Matsumoto et al.   Nature Nanotechnology

Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells

(2016) E. Bourseau-Guilmain et al.   Nature Communications

Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms

(2016) Jinho Kang et al.   Cancer Research and Treatment

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI

(2016) Chengjian Mao et al.   Scientific Reports

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Energy independent uptake and release of polystyrene nanoparticles in primary mammalian cell cultures

(2015) Ilaria Fiorentino et al.   EXPERIMENTAL CELL RESEARCH

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life

(2015) Raffaella Palumbo et al.   Drug Design Development and Therapy

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

(2015) Miguel A. S. Cavadas et al.   Scientific Reports

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

(2014) K-S Seo et al.   ONCOGENE

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

(2014) Suneil Jain et al.   RADIOTHERAPY AND ONCOLOGY

Efficacy and toxicity profile of pegylated liposomal doxorubicin (Caelyx) in patients with advanced breast cancer

(2013) Joachim Rom et al.   ANTI-CANCER DRUGS

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Biotargeted nanomedicines for cancer: six tenets before you begin

(2013) Michael S Goldberg et al.   Nanomedicine

Exploiting Endocytosis for Nanomedicines

(2013) A. Akinc et al.   Cold Spring Harbor Perspectives in Biology

Cancer nanomedicines: So many papers and so few drugs!

(2012) Vincent J. Venditto et al.   ADVANCED DRUG DELIVERY REVIEWS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Endocytosis and Intracellular Trafficking as Gateways for Nanomedicine Delivery: Opportunities and Challenges

(2012) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure

(2012) Sason Torosean et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells

(2011) Gemma Navarro et al.   Nanomedicine

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

(2011) Christian Frezza et al.   PLoS One

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

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