A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

The antifungal pipeline: a reality check

(2017) John R. Perfect   NATURE REVIEWS DRUG DISCOVERY

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of yeast-to-filamentous growth transitions in Candida albicans by a small molecule inducer of mammalian apoptosis

(2017) Joy Goffena et al.   YEAST

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

(2017) Jesus A. Romo et al.   mBio

Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility to Fluconazole in Saccharomyces cerevisiae and Candida Species

(2017) Liesbeth Demuyser et al.   mBio

Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis

(2017) Hagit Bar-Yosef et al.   Scientific Reports

The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway

(2017) Carlos García et al.   mSphere

Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors

(2016) Taissa Vila et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The TIM23 mitochondrial protein import complex: function and dysfunction

(2016) Keren Demishtein-Zohary et al.   CELL AND TISSUE RESEARCH

Hgc1-Cdc28–how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?

(2016) Yue Wang   JOURNAL OF MICROBIOLOGY

TheCandidaGenome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

(2016) Marek S. Skrzypek et al.   NUCLEIC ACIDS RESEARCH

Exploiting mitochondria as targets for the development of new antifungals

(2016) Dongmei Li et al.   Virulence

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

(2015) Shriya Raj et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans

(2015) Julien Chaillot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biological and medicinal significance of benzofuran

(2015) Reshma J. Nevagi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pan Assay Interference Compounds (PAINS) and Other Promiscuous Compounds in Antifungal Research

(2015) Martin Pouliot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global analysis of fungal morphology exposes mechanisms of host cell escape

(2015) Teresa R. O’Meara et al.   Nature Communications

Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans

(2015) Kevin Kim et al.   Annals of Clinical Microbiology and Antimicrobials

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus

(2015) Rajmohan Rajamuthiah et al.   PLoS One

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

BoxPlotR: a web tool for generation of box plots

(2014) Michaela Spitzer et al.   NATURE METHODS

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

(2014) Tinghong Ye et al.   PLoS One

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

(2013) Dominic Hoepfner et al.   MICROBIOLOGICAL RESEARCH

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

(2013) A. Fazly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

(2012) F. Imperi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

(2012) S. Michal Jazwinski et al.   Frontiers in Physiology

Salicylanilide Ester Prodrugs as Potential Antimicrobial Agents - a Review

(2011) Martin Kratky et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

(2011) Miguel Shingu-Vazquez et al.   EUKARYOTIC CELL

Candida albicansdimorphism as a therapeutic target

(2011) Ilse D Jacobsen et al.   Expert Review of Anti-Infective Therapy

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata

(2011) D. O. Inglis et al.   NUCLEIC ACIDS RESEARCH

Friend or foe: using systems biology to elucidate interactions between fungi and their hosts

(2011) Lisa Rizzetto et al.   TRENDS IN MICROBIOLOGY

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation

(2010) H. Ishizaki et al.   Disease Models & Mechanisms

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy

(2010) Hugo Wurtele et al.   NATURE MEDICINE

Relative Contributions of the Candida albicans ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance

(2009) S. Tsao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Targeting virulence: A new paradigm for antifungals

(2009) Katharina Gauwerky et al.   DRUG DISCOVERY TODAY

Hyphal content determines the compression strength of Candida albicans biofilms

(2009) E. Paramonova et al.   MICROBIOLOGY-SGM

Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis

(2009) M. F. Dunn et al.   MICROBIOLOGY-SGM

ABC Transporter Cdr1p Contributes More than Cdr2p Does to Fluconazole Efflux in Fluconazole-Resistant Candida albicans Clinical Isolates

(2008) A. R. Holmes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional  -oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane

(2008) K. Piekarska et al.   MICROBIOLOGY-SGM

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

3-D QSAR and Molecular Docking Studies on Aryl Benzofuran-2-yl Ketoxime Derivatives asCandida albicansN-myristoyl transferase Inhibitors

(2008) Vikas N. Telvekar et al.   Quantitative structure-activity relationships & combinatorial science