Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance

Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients

(2016) M. B. Ezzelarab et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis

(2016) Giovanni Almanzar et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses

(2016) Josh Levitsky et al.   PLoS One

Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers

(2015) J. R. Leventhal et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Sequential Monitoring and Stability ofEx Vivo-Expanded Autologous and Nonautologous Regulatory T Cells Following Infusion in Nonhuman Primates

(2015) H. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor Kidney and Hematopoietic Cell Transplantation

(2015) J. D. Scandling et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells

(2015) Lorenzo Gallon et al.   TRANSPLANTATION

Immune Reconstitution/Immunocompetence in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplants

(2015) Joseph R. Leventhal et al.   TRANSPLANTATION

Long-Term Results in Recipients of Combined HLA-Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression

(2014) T. Kawai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region

(2014) Maura Rossetti et al.   JOURNAL OF IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genomic Biomarkers Correlate with HLA-Identical Renal Transplant Tolerance

(2013) J. R. Leventhal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Design of CD40 Agonists and Their Use in Growing B Cells for Cancer Immunotherapy

(2012) Richard S. Kornbluth et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell Transplantation

(2012) J. Leventhal et al.   Science Translational Medicine

Mechanisms of Donor-Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation

(2011) G. Andreola et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Intragraft Regulatory T Cells in Protocol Biopsies Retain Foxp3 Demethylation and Are Protective Biomarkers for Kidney Graft Outcome

(2011) O. Bestard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Favorable effects of alemtuzumab on allospecific regulatory T-cell generation

(2011) Josh Levitsky et al.   HUMAN IMMUNOLOGY

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation

(2011) Oriol Bestard et al.   TRANSPLANT INTERNATIONAL

Allospecific Regulatory Effects of Sirolimus and Tacrolimus in the Human Mixed Lymphocyte Reaction

(2011) Josh Levitsky et al.   TRANSPLANTATION

Ex Vivo-Expanded Natural CD4+CD25+ Regulatory T Cells Synergize With Host T-Cell Depletion to Promote Long-Term Survival of Allografts

(2010) G. Xia et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

The Human “Treg MLR”: Immune Monitoring for FOXP3+ T Regulatory Cell Generation

(2009) Josh Levitsky et al.   TRANSPLANTATION

Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells

(2008) W. Tu et al.   BLOOD

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

(2008) Jorieke H. Peters et al.   PLoS One