Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction

TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation

(2016) Ayaka Yoshida et al.   Scientific Reports

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4

(2015) Shikha Kumari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation

(2015) Sonya M. Hanson et al.   BIOPHYSICAL JOURNAL

The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature

(2015) Khadija M. Alawi et al.   FASEB JOURNAL

ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress

(2015) Cristian Zaelzer et al.   Cell Reports

Cholesterol Modulates the Dimer Interface of the β2-Adrenergic Receptor via Cholesterol Occupancy Sites

(2014) Xavier Prasanna et al.   BIOPHYSICAL JOURNAL

Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay

(2014) Alexey M. Petrov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses

(2014) A.H. Klein et al.   NEUROSCIENCE

Protter: interactive protein feature visualization and integration with experimental proteomic data

(2013) Ulrich Omasits et al.   BIOINFORMATICS

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Why Do Arginine and Lysine Organize Lipids Differently? Insights from Coarse-Grained and Atomistic Simulations

(2013) Zhe Wu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of Cholesterol Depletion on the Pore Dilation of TRPV1

(2013) Erik T Jansson et al.   Molecular Pain

Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data

(2013) Zoltán Winter et al.   Molecular Pain

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Relevance of Lysine Snorkeling in the Outer Transmembrane Domain of Small Viral Potassium Ion Channels

(2012) Manuela Gebhardt et al.   BIOCHEMISTRY

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

(2012) Hui-Yi Kua et al.   NATURE CELL BIOLOGY

Conservation of Tubulin-Binding Sequences in TRPV1 throughout Evolution

(2012) Puspendu Sardar et al.   PLoS One

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

(2011) Giovanni Picazo-Juárez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol asymmetry in synaptic plasma membranes

(2011) W. Gibson Wood et al.   JOURNAL OF NEUROCHEMISTRY

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Basic amino-acid side chains regulate transmembrane integrin signalling

(2011) Chungho Kim et al.   NATURE

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

(2011) Carlos J. Baier et al.   Scientific Reports

Chemical versus Mechanical Perturbations on the Protonation State of Arginine in Complex Lipid Membranes: Insights from Microscopic pKa Calculations

(2010) Jejoong Yoo et al.   BIOPHYSICAL JOURNAL

Consequences of phosphate-arginine complexes in voltage gated ion channels

(2010) Michael E. Green   Channels

Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels

(2010) Stepana Boukalova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bicarbonate Induces Membrane Reorganization and CBR1 and TRPV1 Endocannabinoid Receptor Migration in Lipid Microdomains in Capacitating Boar Spermatozoa

(2010) Laura Botto et al.   JOURNAL OF MEMBRANE BIOLOGY

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line

(2009) Éva Szőke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

(2009) Benjamin R. Myers et al.   PLoS One

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Domain coupling in asymmetric lipid bilayers

(2008) Volker Kiessling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Does Arginine Remain Protonated in the Lipid Membrane? Insights from Microscopic pKa Calculations

(2008) Jejoong Yoo et al.   BIOPHYSICAL JOURNAL

Distribution of Amino Acids in a Lipid Bilayer from Computer Simulations

(2008) Justin L. MacCallum et al.   BIOPHYSICAL JOURNAL

Rapid, Opioid-sensitive Mechanisms Involved in Transient Receptor Potential Vanilloid 1 Sensitization

(2008) Irina Vetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is Arginine Charged in a Membrane?

(2007) Libo Li et al.   BIOPHYSICAL JOURNAL