MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1

Murine Double Minute-2 Inhibition Ameliorates Established Crescentic Glomerulonephritis

(2016) Shrikant R. Mulay et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of cell proliferation, migration and invasion by a glioma-targeted fusion protein combining the p53 C terminus and MDM2-binding domain

(2016) Jiawen Yu et al.   CELL PROLIFERATION

Valsartan ameliorates podocyte loss in diabetic mice through the Notch pathway

(2016) FENG GAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy

(2016) Jianyun Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury

(2016) Dana Thomasova et al.   Cell Death & Disease

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

(2016) Stefania Trino et al.   Oncotarget

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

(2015) Mariya T. Sweetwyne et al.   DIABETES

Urinary Adiponectin Is an Independent Predictor of Progression to End-Stage Renal Disease in Patients With Type 1 Diabetes and Diabetic Nephropathy

(2015) Nicolae M. Panduru et al.   DIABETES CARE

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

(2015) Samy Hadjadj et al.   DIABETOLOGIA

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

(2015) Shaneabbas Raza et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

p53-Independent Roles of MDM2 in NF-κB Signaling: Implications for Cancer Therapy, Wound Healing, and Autoimmune Diseases

(2015) Dana Thomasova et al.   NEOPLASIA

MDM2-MOF-H4K16ac axis contributes to tumorigenesis induced by Notch

(2014) Yan Liu et al.   FEBS Journal

High Glucose-inducedO-GlcNAcylated Carbohydrate Response Element-binding Protein (ChREBP) Mediates Mesangial Cell Lipogenesis and Fibrosis

(2014) Min-Jung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes

(2014) D. Thomasova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions

(2014) F. Liu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

(2013) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

Podocyte loss involves MDM2-driven mitotic catastrophe

(2013) Shrikant R Mulay et al.   JOURNAL OF PATHOLOGY

Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol

(2013) Artur Zajkowicz et al.   MOLECULAR BIOLOGY REPORTS

MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells

(2012) B. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

(2012) S Singh et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

MDM2 Protein-mediated Ubiquitination of NUMB Protein

(2012) Matylda Sczaniecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice

(2012) Shrikant R. Mulay et al.   KIDNEY INTERNATIONAL

Trp53 regulates Notch 4 signaling through Mdm2

(2011) Y. Sun et al.   JOURNAL OF CELL SCIENCE

Mdm2 Promotes Systemic Lupus Erythematosus and Lupus Nephritis

(2011) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

(2010) Chun-Liang Lin et al.   DIABETES

Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene

(2010) Chun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Notch Activation Differentially Regulates Renal Progenitors Proliferation and Differentiation Toward the Podocyte Lineage in Glomerular Disorders

(2010) Laura Lasagni et al.   STEM CELLS

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE