Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis

‘Hints’ in the horn: diagnostic clues in the stratum corneum

(2017) José Carlos Cardoso et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death

(2017) Heinz Fischer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis

(2017) Misuzu Ueki et al.   PLoS One

The Exonuclease Trex2 Shapes Psoriatic Phenotype

(2016) Joan Manils et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation

(2015) A S Naeem et al.   CELL DEATH AND DIFFERENTIATION

Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes

(2015) Misuzu Ueki et al.   GENE

Suppressing AP1 Factor Signaling in the Suprabasal Epidermis Produces a Keratoderma Phenotype

(2015) Ellen A. Rorke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification

(2015) V Pendaries et al.   Cell Death & Disease

Abnormal Epidermal Barrier Recovery in Uninvolved Skin Supports the Notion of an Epidermal Pathogenesis of Psoriasis

(2014) Li Ye et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

(2014) Heinz Fischer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immune sensing of nucleic acids in inflammatory skin diseases

(2014) Olivier Demaria et al.   Seminars in Immunopathology

Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation

(2014) M Yamamoto-Tanaka et al.   Cell Death & Disease

Cell death by cornification

(2013) Leopold Eckhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy

(2013) Heidemarie Rossiter et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Biogenesis and Proteolytic Processing of Lysosomal DNase II

(2013) Susumu Ohkouchi et al.   PLoS One

Mechanisms and emerging functions of DNA degradation in the epidermis

(2012) Leopold Eckhart   Frontiers in Bioscience-Landmark

Caspase-14-Deficient Mice Are More Prone to the Development of Parakeratosis

(2012) Esther Hoste et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Essential Role of the Keratinocyte-Specific Endonuclease DNase1L2 in the Removal of Nuclear DNA from Hair and Nails

(2011) Heinz Fischer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DNase 2 Is the Main DNA-Degrading Enzyme of the Stratum Corneum

(2011) Heinz Fischer et al.   PLoS One

Benign versus malignant parakeratosis: a nuclear morphometry study

(2010) Jie Song et al.   MODERN PATHOLOGY

Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice

(2009) D. Parra et al.   CANCER RESEARCH

Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification

(2007) Marianne Demerjian et al.   AMERICAN JOURNAL OF PATHOLOGY