Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 133, Issue 3, Pages 742-750Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2012.350
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Funding
- Flanders Institute for Biotechnology (VIB)
- Ghent University
- European grant, FP6 Integrated Project Epistem [LSHB-CT-2005-019067]
- European grant, COST action [SKINBAD BM0903]
- Belgian grants, Interuniversity Attraction Poles [IAP 6/18]
- Flemish grants, Fonds Wetenschappelijke Onderzoek Vlaan-deren [G.0226.09, 1.5.169.08]
- Ghent University grants [BOF-GOA-12.0505.02]
- Flemish Government [BOF09/01M00709]
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Caspase-14 is an important protease in the proper formation of a fully functional skin barrier. Newborn mice that are deficient in caspase-14 exhibit increased transepidermal water loss and are highly sensitive to UVB-induced photodamage. Decreased caspase-14 expression and incomplete caspase-14 processing in lesional psoriatic parakeratotic stratum corneum has been reported previously. In this study, we show that caspase-14-deficient skin frequently displays incompletely cornified cells in the transitional zone between the granular and the cornified layers, pointing to a delay in cornification. We also demonstrate that after challenge of epidermal permeability barrier function by repetitive acetone treatment, a higher incidence of large parakeratotic plaques was observed in caspase-14-deficient skin. Furthermore, caspase-14-deficient mice are more prone than control mice to the development of parakeratosis upon induction of psoriasis-like dermatitis by imiquimod treatment. These results glow that lack of caspase-14 expression predisposes to the development of parakeratosis and that caspase-14 ha an important role in keratinocyte; terminal differentiation and the maintenance of normal stratum corneum, especially in conditions causing epidermal hyperproliferation. Journal of Investigative Dermatology (2013) 133, 742-750; doi:10.1038/jid.2012.350; published online 27 September 2012
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