Tumor cells and their crosstalk with endothelial cells in 3D spheroids

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

(2016) Surya P. Lamichhane et al.   BMC CANCER

The next level of 3D tumour models: immunocompetence

(2016) Agata Nyga et al.   DRUG DISCOVERY TODAY

Protein-structure-guided discovery of functional mutations across 19 cancer types

(2016) Beifang Niu et al.   NATURE GENETICS

Genomic diversity of colorectal cancer: Changing landscape and emerging targets

(2016) Daniel H Ahn et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

(2016) S. P. Kar et al.   Cancer Discovery

Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors

(2016) Valentina Cirello et al.   Oncotarget

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

(2016) Vito Longo et al.   Oncotarget

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model

(2016) Marta Cavo et al.   Scientific Reports

Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro

(2015) Maximilian Heiss et al.   FASEB JOURNAL

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs

(2015) Ekaterina Schreiber-Brynzak et al.   INVESTIGATIONAL NEW DRUGS

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

(2015) Choong Kim et al.   LAB ON A CHIP

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

(2015) Philip Vitorino et al.   NATURE

Database of Genomic Biomarkers for Cancer Drugs and Clinical Targetability in Solid Tumors

(2015) Rodrigo Dienstmann et al.   Cancer Discovery

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

(2015) Maria A. Theodoraki et al.   Oncotarget

Non-Invasive In Vivo Imaging and Quantification of Tumor Growth and Metastasis in Rats Using Cells Expressing Far-Red Fluorescence Protein

(2015) Jon Christensen et al.   PLoS One

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer

(2014) Britta Weigelt et al.   ADVANCED DRUG DELIVERY REVIEWS

Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

(2014) Zeynep Dereli-Korkut et al.   ANALYTICAL CHEMISTRY

Engineered three-dimensional microfluidic device for interrogating cell-cell interactions in the tumor microenvironment

(2014) K. Hockemeyer et al.   Biomicrofluidics

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment

(2014) Yiming Niu et al.   MOLECULAR PHARMACEUTICS

Serum albumin in 2D: A Langmuir monolayer approach

(2013) Nicholas F. Crawford et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Couldpericytic mimicryrepresent another type of melanoma cell plasticity with embryonic properties?

(2013) Claire Lugassy et al.   Pigment Cell & Melanoma Research

Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells

(2012) B. R. Desroches et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Translational research: 4 ways to fix the clinical trial

(2011) Heidi Ledford   NATURE

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Biomaterials offer cancer research the third dimension

(2010) Dietmar W. Hutmacher   NATURE MATERIALS

Emerging New Technologies in Pharamcogenomics: Rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1)

(2010) Toshihisa Ishikawa et al.   PHARMACOLOGY & THERAPEUTICS

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

Spheroid-based human endothelial cell microvessel formation in vivo

(2009) Anna M Laib et al.   Nature Protocols

Gene-Expression Signatures in Breast Cancer

(2009) Christos Sotiriou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype

(2008) Katharine L. Sodek et al.   INTERNATIONAL JOURNAL OF CANCER

In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells

(2008) Zhijian Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

(2008) Britta Weigelt et al.   SEMINARS IN CANCER BIOLOGY