The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5-lipoxygenase-activating protein (FLAP)

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Addition of a 5-lipoxygenase-activating protein inhibitor to an inhaled corticosteroid (ICS) or an ICS/long-acting beta-2-agonist combination in subjects with asthma

(2013) Neil G. Snowise et al.   CURRENT MEDICAL RESEARCH AND OPINION

5-Lipoxygenase inhibitors: a review of recent patents (2010 – 2012)

(2013) Bettina Hofmann et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study

(2013) Richard MA Follows et al.   RESPIRATORY RESEARCH

Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)

(2012) Erden Banoglu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma

(2012) S. E. Kent et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer

(2012) Angela M. Bair et al.   MOLECULAR BIOLOGY OF THE CELL

Leukotrienes as Modifiers of Preclinical Atherosclerosis?

(2012) Graziano Riccioni et al.   TheScientificWorldJOURNAL

On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo

(2011) C Pergola et al.   BRITISH JOURNAL OF PHARMACOLOGY

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes

(2011) Carlo Pergola et al.   FASEB JOURNAL

5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor

(2011) Nicholas S. Stock et al.   JOURNAL OF MEDICINAL CHEMISTRY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-Lipoxygenase inhibitors: a review of recent developments and patents

(2010) Carlo Pergola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

(2009) Magnus Back   CURRENT PHARMACEUTICAL DESIGN

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

(2009) Andreas Koeberle et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

(2009) John H. Hutchinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

(2008) X Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

(2008) C. Pergola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

(2008) J EVANS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES