Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors

Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis

(2013) Naga Chalasani   ANNALS OF INTERNAL MEDICINE

Rationally Designed Multitarget Agents Against Inflammation and Pain

(2013) S. H. Hwang et al.   CURRENT MEDICINAL CHEMISTRY

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants

(2012) Katharina Hofheinz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors

(2012) Yiran Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma

(2012) Rhys L. Evans et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

(2012) Daniel Moser et al.   ACS Medicinal Chemistry Letters

Potent Inhibitors of 5-Lipoxygenase Identified using Pseudoreceptors

(2011) Carmen B. Rödl et al.   ChemMedChem

Novel Cytochrome P450-Mediated Ring Opening of the 1,3,4-Oxadiazole in Setileuton, a 5-Lipoxygenase Inhibitor

(2011) C. M. Maciolek et al.   DRUG METABOLISM AND DISPOSITION

5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor

(2011) Nicholas S. Stock et al.   JOURNAL OF MEDICINAL CHEMISTRY

The efficacy and tolerability of MK-0633, a 5-lipoxygenase inhibitor, in chronic asthma

(2011) Yasmine S. Wasfi et al.   RESPIRATORY MEDICINE

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee

(2010) Robert M. Levy et al.   ADVANCES IN THERAPY

Treatment With 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients With Recent Acute Coronary Syndrome

(2010) Jean-Claude Tardif et al.   Circulation-Cardiovascular Imaging

Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein (FLAP)

(2010) G Bain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro-In Vivo Correlation and Translation to the Clinical Outcome for CJ-13,610, a Novel Inhibitor of 5-Lipoxygenase

(2010) J. Matthew Hutzler et al.   DRUG METABOLISM AND DISPOSITION

MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease

(2010) Jonathan A. Bernstein et al.   RESPIRATORY MEDICINE

The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

(2010) Yves Ducharme et al.   ACS Medicinal Chemistry Letters

The use of gastrointestinal intubation studies for controlled release development

(2009) Steven C. Sutton   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

(2009) Luz A. Cortes-Burgos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bioactivity-guided mapping and navigation of chemical space

(2009) Steffen Renner et al.   Nature Chemical Biology

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

2-ABT-S-oxide detoxification by glutathioneS-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton

(2009) E.M. Joshi et al.   XENOBIOTICA

Scaffold-Hopping Cascade Yields Potent Inhibitors of 5-Lipoxygenase

(2008) Bettina Hofmann et al.   ChemMedChem

PhAST: Pharmacophore alignment search tool

(2008) Volker Hähnke et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Homology modeling of 5-lipoxygenase and hints for better inhibitor design

(2008) P. Aparoy et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Leukotrienes, Antileukotrienes and Asthma

(2008) Paolo Montuschi   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening

(2008) Yusuf Tanrikulu et al.   NATURE REVIEWS DRUG DISCOVERY

Licofelone: The answer to unmet needs in osteoarthritis therapy?

(2008) Shrinivas K. Kulkarni et al.   Current Rheumatology Reports