Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

(2016) Lauren Reinke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice

(2016) Kalavathi Dasuri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Animal models of scleroderma

(2016) Roberta G. Marangoni et al.   CURRENT OPINION IN RHEUMATOLOGY

Dermal Adipocytes: From Irrelevance to Metabolic Targets?

(2016) Ilja L. Kruglikov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adiponectin, the past two decades

(2016) Zhao V. Wang et al.   Journal of Molecular Cell Biology

Dermal white adipose tissue: a new component of the thermogenic response

(2015) Caroline M. Alexander et al.   JOURNAL OF LIPID RESEARCH

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

(2015) L.-j. Zhang et al.   SCIENCE

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Systemic sclerosis

(2015) Yannick Allanore et al.   Nature Reviews Disease Primers

Defining dermal adipose tissue

(2014) Ryan R. Driskell et al.   EXPERIMENTAL DERMATOLOGY

Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis

(2014) Pradeep Kumar et al.   FASEB JOURNAL

Cot/tpl2 participates in the activation of macrophages by adiponectin

(2014) Carlos Sanz-Garcia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Designer Adiponectin Receptor Agonist Stabilizes Metabolic Function and Prevents Brain Injury Caused by HIV Protease Inhibitors

(2014) Jennifer K. Pepping et al.   Journal of Neuroimmune Pharmacology

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

(2014) Ildiko Kasza et al.   PLoS Genetics

Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis

(2014) Rebecca Lee et al.   Frontiers in Pharmacology

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

(2013) Frank van den Hoogen et al.   ARTHRITIS AND RHEUMATISM

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

(2013) B. A. Schmidt et al.   DEVELOPMENT

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

(2013) Monique Hinchcliff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adiponectin Promotes Functional Recovery after Podocyte Ablation

(2013) J. M. Rutkowski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ronning After the Adiponectin Receptors

(2013) W. L. Holland et al.   SCIENCE

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

(2012) Michal Tomčík et al.   CYTOKINE

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Unravelling hair follicle-adipocyte communication

(2012) Barbara Schmidt et al.   EXPERIMENTAL DERMATOLOGY

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts

(2012) X. Shi-wen et al.   RHEUMATOLOGY

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as a biomarker?

(2012) Katja Lakota et al.   ARTHRITIS RESEARCH & THERAPY

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

(2012) Feng Fang et al.   ARTHRITIS RESEARCH & THERAPY

Obesity and Pulmonary Arterial Hypertension: Is Adiponectin the Molecular Link between these Conditions?

(2012) Ross Summer et al.   Pulmonary Circulation

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

(2011) Laszlo Otvos et al.   BMC BIOTECHNOLOGY

Adipose tissue mass and location affect circulating adiponectin levels

(2011) A. T. Turer et al.   DIABETOLOGIA

Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients

(2011) Hiroki Arakawa et al.   EXPERIMENTAL DERMATOLOGY

Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis

(2011) Y. Masui et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Adiponectin Decreases Pulmonary Arterial Remodeling in Murine Models of Pulmonary Hypertension

(2010) Meiqian Weng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

(2009) Mohit Kapoor et al.   ARTHRITIS AND RHEUMATISM

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis

(2008) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of Cyclophilin B is Associated with Malignant Progression and Regulation of Genes Implicated in the Pathogenesis of Breast Cancer

(2008) Feng Fang et al.   AMERICAN JOURNAL OF PATHOLOGY

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-γ

(2008) Asish K Ghosh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter

(2008) Feng Fang et al.   BMC BIOTECHNOLOGY

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One