Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

Conserved extracellular cysteines differentially regulate the potentiation produced by Zn2+ in rat P2X4 receptors

(2013) Chao-Ying Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

(2013) Rachael Bartlett et al.   MEDIATORS OF INFLAMMATION

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X1 receptor channel currents

(2013) Sun-Hye Choi et al.   MOLECULES AND CELLS

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7receptor/NADPH-oxidase signalling and contributes to persistence

(2012) Chul Hee Choi et al.   CELLULAR MICROBIOLOGY

Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor

(2012) Ruotian Jiang et al.   Channels

Tightening of the ATP-binding sites induces the opening of P2X receptor channels

(2012) Ruotian Jiang et al.   EMBO JOURNAL

Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain

(2012) Shenglan Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

(2012) Maria Barberà-Cremades et al.   FASEB JOURNAL

Reactive oxygen species contribute to the promotion of the ATP-mediated proliferation of mouse skeletal myoblasts

(2012) Marina Sciancalepore et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species

(2012) H. Miki et al.   JOURNAL OF BIOCHEMISTRY

High Potency Zinc Modulation of Human P2X2 Receptors and Low Potency Zinc Modulation of Rat P2X2 Receptors Share a Common Molecular Mechanism

(2012) Sukanya Punthambaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling

(2012) Anmar Khadra et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure–Activity Relationships and Optimization of 3,5-Dichloropyridine Derivatives As Novel P2X7 Receptor Antagonists

(2012) Won-Gil Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions

(2012) Emma L. Mead et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Covalent Modification of Mutant Rat P2X2 Receptors with a Thiol-Reactive Fluorophore Allows Channel Activation by Zinc or Acidic pH without ATP

(2012) Shlomo S. Dellal et al.   PLoS One

Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor

(2012) E. Lorinczi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and functional properties of P2X receptors—recent progress and persisting challenges

(2012) Karina Kaczmarek-Hájek et al.   Purinergic Signalling

P2X7 receptor activation induces reactive oxygen species formation in erythroid cells

(2012) Bin Wang et al.   Purinergic Signalling

Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse

(2011) Young-Hwan Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations

(2011) Wolfgang Nörenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice

(2011) Christian Furlan-Freguia et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium-dependent block of P2X7 receptor channel function is allosteric

(2011) Zonghe Yan et al.   JOURNAL OF GENERAL PHYSIOLOGY

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

Agonist trapped in ATP-binding sites of the P2X2 receptor

(2011) R. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial P2X7 receptor current density increased following long-term exposure to rotenone

(2011) Xiao-Fei Gao et al.   Purinergic Signalling

Acid sensing by visceral afferent neurones

(2010) P. Holzer   Acta Physiologica

Functional expression of purinergic P2X7 receptors in pregnant rat myometrium

(2010) Hiroshi Miyoshi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of protons on macroscopic and single-channel currents mediated by the human P2X7 receptor

(2010) B. Flittiger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stimulation by P2X7 receptors of calcium-dependent production of reactive oxygen species (ROS) in rat submandibular glands

(2010) U. Fontanils et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural Insights into the Function of P2X4: An ATP-Gated Cation Channel of Neuroendocrine Cells

(2010) Stanko S. Stojilkovic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7Receptor Current Facilitation

(2010) Sébastien Roger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

(2010) Z. Yan et al.   JOURNAL OF NEUROSCIENCE

Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages

(2010) Gladys Corrêa et al.   MICROBES AND INFECTION

Sensing Muscle Ischemia: Coincident Detection of Acid and ATP via Interplay of Two Ion Channels

(2010) William T. Birdsong et al.   NEURON

Role of nitric oxide on purinergic signalling in the cochlea

(2010) Narinobu Harada   Purinergic Signalling

Protein kinase A regulation of P2X4 receptors: Requirement for a specific motif in the C-terminus

(2009) David A. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of the amino acid residues in the extracellular domain of rat P2X7receptor involved in functional inhibition by acidic pH

(2009) X Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels

(2009) WJ Wilkinson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn

(2009) Yun Gao et al.   BURNS

The Cdk5 Kinase Downregulates ATP-Gated Ionotropic P2X3 Receptor Function Via Serine Phosphorylation

(2009) Asha Nair et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The C-terminal Src Inhibitory Kinase (Csk)-mediated Tyrosine Phosphorylation Is a Novel Molecular Mechanism to Limit P2X3Receptor Function in Mouse Sensory Neurons

(2009) Marianna D'Arco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages

(2009) S. F. Moore et al.   JOURNAL OF IMMUNOLOGY

Neurosteroids differentially modulate P2X4ATP-gated channels through non-genomic interactions

(2009) Juan Francisco Codocedo et al.   JOURNAL OF NEUROCHEMISTRY

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors

(2009) Maya Popova et al.   JOURNAL OF NEUROCHEMISTRY

Reactive Oxygen Species Potentiate the P2X2 Receptor Activity through Intracellular Cys430

(2009) C. Coddou et al.   JOURNAL OF NEUROSCIENCE

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone

(2009) Mathias De Roo et al.   NEUROPHARMACOLOGY

Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

(2009) Lisa Y. Lenertz et al.   Purinergic Signalling

Inhibition of P2X receptor-mediated inward current by protein kinase C in small-diameter dorsal root ganglion neurons of adult rats

(2009) Bi-Hua Bie et al.   Neuroscience Bulletin

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Inhibitory interaction between P2X 4 and GABA C ρ1 receptors

(2008) Rong Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors

(2008) Samantha F. Moore et al.   BIOCHEMICAL PHARMACOLOGY

Purinergic-mediated Ca2+ influx in Dictyostelium discoideum

(2008) Melanie J. Ludlow et al.   CELL CALCIUM

Inhibition of P2X7 receptors by divalent cations: old action and new insight

(2008) Lin-Hua Jiang   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Molecular Shape, Architecture, and Size of P2X4Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy

(2008) Mark T. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

(2008) Takuya Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The P2X7Receptor Channel Pore Dilates under Physiological Ion Conditions

(2008) Zonghe Yan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2receptors

(2008) Sean C. Friday et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of the pH sensitivity of human P2X3receptors by N-linked glycosylation

(2008) Kerstin Wirkner et al.   JOURNAL OF NEUROCHEMISTRY

Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1

(2008) Alan R. Light et al.   JOURNAL OF NEUROPHYSIOLOGY

Opposite Effects of Zinc on Human and Rat P2X2 Receptors

(2008) R. K. Tittle et al.   JOURNAL OF NEUROSCIENCE

Facilitation of P2X7 Receptor Currents and Membrane Blebbing via Constitutive and Dynamic Calmodulin Binding

(2008) S. Roger et al.   JOURNAL OF NEUROSCIENCE

Gating the pore of P2X receptor channels

(2008) Mufeng Li et al.   NATURE NEUROSCIENCE

Pharmacological evidence for the stimulation of NADPH oxidase by P2X7 receptors in mouse submandibular glands

(2008) Michèle Seil et al.   Purinergic Signalling

Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1

(2008) S. Chaumont et al.   Science Signaling

Negative and positive allosteric modulators of the P2X7receptor

(2007) A D Michel et al.   BRITISH JOURNAL OF PHARMACOLOGY