Interleukin-1β pre-treated bone marrow stromal cells alleviate neuropathic pain through CCL7-mediated inhibition of microglial activation in the spinal cord

SnapShot: Microglia in Disease

(2016) Simon Beggs et al.   CELL

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?

(2016) Gareth R. Tibbs et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

(2015) Maren Lindner et al.   BRAIN

Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve

(2015) Juliette Van Steenwinckel et al.   BRAIN BEHAVIOR AND IMMUNITY

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

(2015) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

CXCL13 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting miR-23a Expression

(2015) Feng Tian et al.   Stem Cells International

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

(2014) Joshua W. Little et al.   BRAIN

Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats

(2014) Fang-Ting Liu et al.   CNS Neuroscience & Therapeutics

CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model

(2014) Marius Krauthausen et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

(2014) Sabrina Schäfer et al.   Journal of Neuroinflammation

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

Modulating the delicate glial–neuronal interactions in neuropathic pain: Promises and potential caveats

(2014) Vinod Tiwari et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Grafted Bone Marrow Stromal Cells

(2014) Li-Xin Zhang et al.   NEUROSCIENTIST

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study

(2014) Dasa Cizkova et al.   Scientific Reports

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain

(2013) Satoshi Imai et al.   BRAIN

Up-regulation of interleukin-23 induces persistent allodynia via CX3CL1 and interleukin-18 signaling in the rat spinal cord after tetanic sciatic stimulation

(2013) Chao Bian et al.   BRAIN BEHAVIOR AND IMMUNITY

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

(2013) Victoria L. Gadd et al.   HEPATOLOGY

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT signaling underlies the pathogenesis of neuropathic pain in rodents

(2013) Yan-Kai Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

The liver–brain axis in liver failure: neuroinflammation and encephalopathy

(2013) Roger F. Butterworth   Nature Reviews Gastroenterology & Hepatology

Multipotent Stromal Cells Alleviate Inflammation, Neuropathology, and Symptoms Associated with Globoid Cell Leukodystrophy in the Twitcher Mouse

(2013) Brittni A. Scruggs et al.   STEM CELLS

Emerging roles for multipotent, bone marrow-derived stromal cells in host defense

(2012) J. J. Auletta et al.   BLOOD

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

(2011) Knut Biber et al.   EMBO JOURNAL

mRNA-seq with agnostic splice site discovery for nervous system transcriptomics tested in chronic pain

(2010) P. Hammer et al.   GENOME RESEARCH

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Mesenchymal Lineage Stem Cells Have Pronounced Anti-Inflammatory Effects in the Twitcher Mouse Model of Krabbe's Disease

(2010) Cynthia B. Ripoll et al.   STEM CELLS

Matrix metalloprotease regulation of neuropathic pain

(2009) Ru-Rong Ji et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE