Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

(2016) Sebastian George Barton Furness et al.   CELL

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

(2014) Ryan T. Strachan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

(2014) H. Ongun Onaran et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Quantifying biased agonism: understanding the links between affinity and efficacy

(2013) Sudarshan Rajagopal   NATURE REVIEWS DRUG DISCOVERY

Modeling of Bias for the Analysis of Receptor Signaling in Biochemical Systems

(2012) Larry S. Barak et al.   BIOCHEMISTRY

Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation

(2012) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Where have all the active receptor states gone?

(2012) H Ongun Onaran et al.   Nature Chemical Biology

A Luminescent Biosensor with Increased Dynamic Range for Intracellular cAMP

(2011) Brock F. Binkowski et al.   ACS Chemical Biology

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling

(2011) Ida Casella et al.   BIOCHEMICAL JOURNAL

Biased Ligands for Better Cardiovascular Drugs

(2011) Scott M. DeWire et al.   CIRCULATION RESEARCH

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

(2011) Wayne Stallaert et al.   Expert Opinion on Drug Discovery

Quantifying Ligand Bias at Seven-Transmembrane Receptors

(2011) S. Rajagopal et al.   MOLECULAR PHARMACOLOGY

Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions

(2010) Paola Molinari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Selectivity of Agonists for the Active State of M1 to M4 Muscarinic Receptor Subtypes

(2008) K. W. Figueroa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells

(2007) Paola Molinari et al.   BIOCHEMICAL JOURNAL