Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
出版年份 2017 全文链接
标题
Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
作者
关键词
-
出版物
Scientific Reports
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-03-14
DOI
10.1038/srep44247
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy
- (2016) Sebastian George Barton Furness et al. CELL
- The role of kinetic context in apparent biased agonism at GPCRs
- (2016) Carmen Klein Herenbrink et al. Nature Communications
- Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)
- (2014) Ryan T. Strachan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling
- (2014) H. Ongun Onaran et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Recent developments in biased agonism
- (2013) James W Wisler et al. CURRENT OPINION IN CELL BIOLOGY
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Quantifying biased agonism: understanding the links between affinity and efficacy
- (2013) Sudarshan Rajagopal NATURE REVIEWS DRUG DISCOVERY
- Modeling of Bias for the Analysis of Receptor Signaling in Biochemical Systems
- (2012) Larry S. Barak et al. BIOCHEMISTRY
- Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation
- (2012) Ali I. Kaya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Where have all the active receptor states gone?
- (2012) H Ongun Onaran et al. Nature Chemical Biology
- A Luminescent Biosensor with Increased Dynamic Range for Intracellular cAMP
- (2011) Brock F. Binkowski et al. ACS Chemical Biology
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling
- (2011) Ida Casella et al. BIOCHEMICAL JOURNAL
- Biased Ligands for Better Cardiovascular Drugs
- (2011) Scott M. DeWire et al. CIRCULATION RESEARCH
- Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors
- (2011) Wayne Stallaert et al. Expert Opinion on Drug Discovery
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
- (2010) Paola Molinari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Selectivity of Agonists for the Active State of M1 to M4 Muscarinic Receptor Subtypes
- (2008) K. W. Figueroa et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells
- (2007) Paola Molinari et al. BIOCHEMICAL JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started