Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis

MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-κB pathway in human osteoarthritis chondrocytes

(2016) Zafar Rasheed et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure

(2016) Gabriel García Caballero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sweet complementarity: the functional pairing of glycans with lectins

(2016) H.-J. Gabius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

(2016) Hans Ippel et al.   GLYCOBIOLOGY

Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network

(2016) Stefan Toegel et al.   JOURNAL OF IMMUNOLOGY

Genetic Deletion of Galectin-3 Does Not Impair Full-Thickness Excisional Skin Healing

(2016) John T. Walker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration

(2016) Ye Tian et al.   MATRIX BIOLOGY

Galectin-1 damages cartilage via inflammation

(2016) Joana Osório   Nature Reviews Rheumatology

Galectin-3 regulates metastatic capabilities and chemotherapy sensitivity in epithelial ovarian carcinoma via NF-κB pathway

(2016) Huaiwu Lu et al.   TUMOR BIOLOGY

Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage

(2016) Heidi L. Reesink et al.   Scientific Reports

Network Monitoring of Adhesion/Growth-Regulatory Galectins: Localization of the Five Canonical Chicken Proteins in Embryonic and Maturing Bone and Cartilage and Their Introduction as Histochemical Tools

(2015) Herbert Kaltner et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts

(2015) Uri Arad et al.   CYTOKINE

Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context

(2015) Sabine André et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Strategies for the prevention of knee osteoarthritis

(2015) Ewa M. Roos et al.   Nature Reviews Rheumatology

The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function

(2015) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

(2015) Fei Fei et al.   Oncotarget

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells

(2015) Yosuke Harazono et al.   Oncotarget

Human chimera-type galectin-3: Defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in neuroblastoma cell growth regulation

(2014) Jürgen Kopitz et al.   BIOCHIMIE

Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration

(2014) Stefan Toegel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

(2013) A. J. Iqbal et al.   JOURNAL OF IMMUNOLOGY

Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein

(2013) Stefan Toegel et al.   ARTHRITIS RESEARCH & THERAPY

Galectins in acute and chronic inflammation

(2012) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins

(2012) Marco Bartoloni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis

(2010) Huamei Forsman et al.   ARTHRITIS AND RHEUMATISM

Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

(2010) Mickaël Krzeminski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

IL-1β and TNF-α alter the glycophenotype of primary human chondrocytes in vitro

(2010) Martin Pabst et al.   CARBOHYDRATE RESEARCH

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

(2010) Hugo Sanchez-Ruderisch et al.   FEBS Journal

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Nitric oxide changes distinct aspects of the glycophenotype of human neuroblastoma NB69 cells

(2010) Marlies Van de Wouwer et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

(2009) Andrew Filer et al.   ARTHRITIS AND RHEUMATISM

Phenotype-related differential α-2,6- or α-2,3-sialylation of glycoprotein N-glycans in human chondrocytes

(2009) S. Toegel et al.   OSTEOARTHRITIS AND CARTILAGE

Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins

(2008) Kerstin Sarter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS