Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect
Authors
Keywords
-
Journal
Scientific Reports
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-06-24
DOI
10.1038/srep28676
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Therapeutic potential of Takeda-G-protein-receptor-5 (TGR5) agonists. Hope or hype?
- (2016) R. J. Hodge et al. DIABETES OBESITY & METABOLISM
- Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases
- (2016) Yanping Xu JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes
- (2015) Hongliang Duan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist
- (2015) Sameer Agarwal et al. ACS Medicinal Chemistry Letters
- Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice
- (2015) Daniel A. Briere et al. PLoS One
- Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes
- (2014) Morten Hansen et al. Current Diabetes Reports
- Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy
- (2014) Dean P. Phillips et al. JOURNAL OF MEDICINAL CHEMISTRY
- Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization
- (2014) Janne Prawitt et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)
- (2012) Rainer E. Martin et al. ChemMedChem
- Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists
- (2012) Hongliang Duan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of triazole-based TGR5 agonists towards orally available agents
- (2012) Kentaro Futatsugi et al. MedChemComm
- Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists
- (2012) David W. Piotrowski et al. ACS Medicinal Chemistry Letters
- TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
- (2012) Taoufiq Harach et al. Scientific Reports
- The structure and function of the glucagon-like peptide-1 receptor and its ligands
- (2011) Dan Donnelly BRITISH JOURNAL OF PHARMACOLOGY
- Role of Bile Acid Sequestrants in the Treatment of Type 2 Diabetes
- (2011) Y. Handelsman DIABETES CARE
- The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target
- (2011) Thijs W.H. Pols et al. DIGESTIVE DISEASES
- The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling
- (2011) Tingting Li et al. MOLECULAR ENDOCRINOLOGY
- TGR5 as a Therapeutic Target for Treating Obesity
- (2010) Min Zhong CURRENT TOPICS IN MEDICINAL CHEMISTRY
- The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
- (2010) Verena Keitel et al. GLIA
- The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
- (2010) Thijs W.H. Pols et al. JOURNAL OF HEPATOLOGY
- TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
- (2009) Charles Thomas et al. Cell Metabolism
- Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists
- (2009) Karen A. Evans et al. JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More