Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy

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Title
Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 57, Issue 8, Pages 3263-3282
Publisher
American Chemical Society (ACS)
Online
2014-03-26
DOI
10.1021/jm401731q

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